Investigation of the mass-spectrometric behavior of aminomethyl and aminomethylene derivatives of tetrahydrofuran

Various tetrahydrofuran‐2‐ylmethylamines have been prepared in good yields by an efficient one‐step synthesis utilizing the reaction of tetrahydrofurfurylchloride with different secondary cyclic amines without any catalyst. The compounds were tested for their in vitro affinity for the (α4)2(β2)3 and α7* nicotinic acetylcholine receptor (nAChR) subtypes. Pyrrolidine, piperidine and azepane containing analogs (1a, 1b, 1c) showed Ki values in the lower micromolar range for these neuronal nAChR subtypes in rat brain.

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Tetrahydrofuranylmethylamines: An efficient and simple one‐step synthesis and biological activities

Limbeck

Gündisch

2003

Journal of Heterocyclic Chem

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Investigation of the mass-spectrometric behavior of aminomethyl and aminomethylene derivatives of tetrahydrofuran

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Tetrahydrofuranylmethylamines: An efficient and simple one‐step synthesis and biological activities

Tetrahydrofuranylmethylamines: An efficient and simple one‐step synthesis and biological activities

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