Investigation of the plasma concentrations and circulating forms of BNP and ANP in orthotopic cardiac transplant recipients

Ventricular natriuretic peptide (BNP) in heart transplantation: BNP correlation with endomyocardial biopsy, laboratory and hemodynamic measures

“…In agreement with our study, most authors have found that BNP concentration remained high after transplantation, and were significantly higher than in healthy controls. [28][29][30] Ationu et al 28 and El Gamel et al 29 likewise found no relation between BNP plasma levels and the existence of heart rejection as determined by biopsy. Masters et al 31 analyzed 77 biopsies in 10 patients between 4 and 40 weeks post-HT.…”

“…20 High BNP values have also been found in patients with high blood pressure, ventricular hypertrophy, ischemic heart disease and other heart diseases, [21][22][23][24][25][26] renal failure subjected to hemodialysis, 12,27 and in heart transplantation. [28][29][30] The utility of BNP in the diagnosis of heart transplant rejection has not been thoroughly investigated to date; the studies were generally limited to few cases with a short follow-up duration and sometimes contradictory results. 31,32 In this context, the simple laboratory assessment of BNP could be very useful in selecting patients for subsequent invasive techniques such as biopsy.…”

Prognostic Value of Brain Natriuretic Peptide in Heart Transplant Patients

“…Similarly, BNP determinations were excluded in the context of circumstances that might be a reason for the temporary increase: acute rejection; high lung pressures; significant renal dysfunction; depression of left ventricular (LV) or right ventricular (RV) systolic function; graft vascular disease; infection; or other organic disorder of any nature. Several studies have shown rising BNP plasma levels in heart transplant patients with significant, acute rejection 12,15,25,26,28,29,32,33 and a marked reduction after effective treatment. 14,34 Furthermore, the relationship between BNP levels and hemodynamic parameters is controversial.…”

Reduced incidence of hypertension after heterotopic cardiac transplantation compared with orthotopic cardiac transplantation

“…Natriuretic peptides are released in response to myocardial stretch or when the myocardium has undergone remodeling and actions include natriuresis, diuresis, and vasodilation (21). Both atrial natriuretic peptide and braintype natriuretic peptide concentrations are elevated after OCT (22). As HHT patients possess two hearts, they may have higher natriuretic peptide levels.…”