Investigation of the Polyphenol Composition, Biological Activities, and Detoxification Properties of Some Medicinal Mushrooms from Turkey

Shomali, Naznoosh; Onar, Okan; Alkan, Tuğçe; Demirtaş, Nergiz; Akata, İlgaz; Yıldırım, Özlem

doi:10.4274/tjps.galenos.2018.03274

Cited by 19 publications

(11 citation statements)

References 22 publications

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“…At a concentration of 1 × 10 −5 g/mL, both the H-1 (water extract) and H-2 (ether extract) fractions of fruit bodies inhibited S. aureus , Candida albicans , Aspergillus niger , and Pseudomonas aeruginosa , with a positive correlation with concentration, but neither inhibited E. coli [ 15 ]. The disc diffusion assay of ethanolic extracts of I. hispidus fruit bodies revealed a minor antimicrobial effect against S. aureus , E. coli , and P. aeruginosa [ 38 ]. Hispolon ( 5 ) and hispidin ( 1 ) were discovered to have antiviral activity, inhibiting the growth of influenza A and B viruses [ 29 ].…”

Section: Biological and Pharmacological Activitiesmentioning

confidence: 99%

“…The discovery of this result, to some extent, revealed the mechanism of the antioxidant activity of hispidin ( 1 ). Furthermore, low doses of ethanolic extracts of I. hispidus fruiting bodies increased GST enzyme activity [ 38 ]. Compound 34 (IC 50 = 0.24 mM) has excellent α-glycosidase inhibitory activity and is more potent than the clinically used acarbose (IC 50 = 0.46 mM) [ 40 ].…”

Section: Biological and Pharmacological Activitiesmentioning

confidence: 99%

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Diverse Metabolites and Pharmacological Effects from the Basidiomycetes Inonotus hispidus

et al. 2022

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Inonotus hispidus mushroom is a popular edible and medicinal mushroom with a long history of use. It is well known as a medicinal fungus with various health benefits for its significant anticancer and immunomodulatory activities. Over the last 60 years, secondary metabolites derived from I. hispidus and their biological activities have been discovered and investigated. Structurally, these compounds are mainly polyphenols and triterpenoids, which have anticancer, anti-inflammatory, antioxidant, antimicrobial, and enzyme inhibitor activities. Here, the secondary metabolites derived from I. hispidus and their activities were systematically and comprehensively classified and summarized, and the biosynthetic pathway of stylylpyrones was deduced and analyzed further. This review contributes to our understanding of I. hispidus and will help with research into natural product chemistry, pharmacology, and the biosynthesis of I. hispidus metabolites. According to this review, I. hispidus could be a promising source of bioactive compounds for health promotion and the development of functional foods.

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Section: Biological and Pharmacological Activitiesmentioning

confidence: 99%

Section: Biological and Pharmacological Activitiesmentioning

confidence: 99%

Diverse Metabolites and Pharmacological Effects from the Basidiomycetes Inonotus hispidus

et al. 2022

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“…[12] Inonotus hispidus is a rare and valuable medicinal fungus, which contains polysaccharides, polyphenol, melanin, and other active substances, and has good antioxidant, antitumor, hypoglycemic, and bacteriostatic functions. [13][14][15] Research on I. hispidus focuses more on polysaccharides than melanin. [13] Melanin is a macromolecular polymer usually polymerized from a variety of cyclic subunits, such as hydroxynaphthol, phenol, and indole.…”

Section: Introductionmentioning

confidence: 99%

Hepatoenteric Protective Effect of Melanin from Inonotus hispidus on Acute Alcoholic Liver Injury in Mice

Yuan

Zhang

et al. 2023

Molecular Nutrition Food Res

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Scope Alcoholic liver disease (ALD) is a common disease with a high incidence. Because traditional drugs have obvious side effects, it is desired to find more effective drugs. Methods and results This study investigates the effects of melanin from Inonotus hispidus fruiting bodies (IHFM) on acute alcoholic injury mice and detects the protective mechanisms via the gut–microbiota–liver axis. The results show that IHFM alleviates mouse liver injury by enhancing alcohol metabolism capacity, reducing inflammation response level and strengthening antioxidant activities. IHFM also improves mouse liver injury by activating Nrf2 signaling pathway and inhibiting toll‐like receptor4 (TLR4)/nuclear factor‐κβ (NF‐κβ) signaling pathway. Furthermore, 16S amplification sequencing shows that IHFM can significantly increase the relative abundance of Lactobacillus reuteri and Lactobacillus johnsonii. The relative abundance of L. reuteri positively correlates with an antioxidant index, while negatively correlates with inflammatory factors. Conclusion IHFM can protect mice from acute alcoholic liver injury by upregulating the Nrf2 signaling pathway, downregulating the TLR4/NF‐κβ signaling pathway, and upregulating the relative abundance of L. reuteri and L. johnsonii, representing a step forward in the development of IHFM.

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“…Being a promising therapeutic agent, G. adspersum should undergo further study for the protection provided against oxidative stress and Alzheimer’s disease. In addition, the ethanolic extract from a Turkish mushroom was examined for its phenol content and its antioxidant and antimicrobial activities [ 37 ].…”

Section: Introductionmentioning

confidence: 99%

Ganoderma adspersum (Ganodermataceae): Investigation of Its Secondary Metabolites and the Antioxidant, Antimicrobial, and Cytotoxic Potential of Its Extracts

Chafouz,

Karavergou,

Tsiftsoglou

et al. 2023

IJMS

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Ganoderma is a genus of wood-degrading mushrooms with medicinal importance. Most Ganoderma species have been studied extensively for their secondary metabolites, biological activities, and ecological value. In this study, the biological activities of the extracts of G. adspersum growing wild on Morus alba trees in the region of Western Thrace (Greece) were evaluated, and the petroleum ether, dichloromethanolic, and methanolic extracts were studied further for their secondary metabolites. Six substances were isolated by chromatographic (Clumn Chromatography (C.C.), High Performance Liquid Chromatography (HPLC)) and spectroscopic methods (Nuclear Magnetic Resonance (NMR)), which were classified in the following categories: (a) unsaturated fatty acids: cis-oleic acid (1); (b) sterols: ergosta-7,22-dien-3-one (2), ergosta-7,22-dien-3-ol (3), and ergosta-5,7,22-trien-3-ol (4); and (c) lanostane-type triterpenoids: applanoxidic acid G (5) and applanoxidic acid A (6). Finally, the biological activities of the extracts were estimated for their antioxidant, antimicrobial, and cytotoxic potential. The methanolic extract of G. adspersum showed the highest total antioxidant activity. The results of the antimicrobial activities indicated that all of the extracts had a minimum inhibitory concentration (MIC) ranging between 39.1 and 312.5 μg/mL. The evaluation of the cytotoxic activity of the samples showed once again that the methanolic extract was the most potent among the examined extracts, with half-maximal inhibitory concentration (IC50) values of 19.22 μg/mL (Hep2c cells), 32.9 μg/mL (RD cells), and 8.94 μg/mL (L2OB cells). Moreover, the bioactivity scores of the isolated secondary metabolites were calculated using the online computer software program Molinspiration. The compounds showed promising bioactivity scores for drug targets.

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Investigation of the Polyphenol Composition, Biological Activities, and Detoxification Properties of Some Medicinal Mushrooms from Turkey

Cited by 19 publications

References 22 publications

Diverse Metabolites and Pharmacological Effects from the Basidiomycetes Inonotus hispidus

Diverse Metabolites and Pharmacological Effects from the Basidiomycetes Inonotus hispidus

Hepatoenteric Protective Effect of Melanin from Inonotus hispidus on Acute Alcoholic Liver Injury in Mice

Ganoderma adspersum (Ganodermataceae): Investigation of Its Secondary Metabolites and the Antioxidant, Antimicrobial, and Cytotoxic Potential of Its Extracts

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