In this work, the method of IR digital holography intended for detection of volumetric defects in ZnGeP2 single crystals has been tested. The holographic method is verified by a comparison of the results obtained with the data obtained by other methods. The spatial resolution of the experimental setup is ~15–20 µm. The volumetric defects of the ZnGeP2 crystal structure (in samples with thickness up to 50 mm) such as growth striations, dislocation chain, and inclusions of the second phase (Zn3P2) shaped as needles up to ~100 µm long and ~10 µm wide have been visualized by the method of IR digital holography.