Investigation of the properties of the oral liquid and polymorphism of the MUC5B gene in children with cystic fibrosis

Abstract

The article presents the study of biophysical and biochemical properties of saliva and polymorphism of the MUC5B protein gene in children with cystic fibrosis. It has been determined that the development of chronic gingivitis in children with cystic fibrosis occurs secondary to an increase in saliva elasticity and a decrease in salivation rate. The presence of the MUC5B gene allele with 9 repeats (59 bp) in the intron 36 in the genotype for cystic fibrosis patients likely indicates a lower tendency to gingivitis, while the patients possessing the allele with 6 repeats in the genotype were found to have a higher percentage of moderate gingivitis. These data could be used to predict the development of chronic gingivitis, depending on the genetic polymorphism of the MUC5B gene and to form risk groups for differentiated prescription of preventive and therapeutic measures.