Investigation of the Protective Effect of Boric Acid Against Hepatotoxic and Nephrotoxic Injury Induced by Acrylamide in Rats

Gündüz, Ercan; YİLDİZHAN, Eda; Yaman, Mine; Sen, Alaattin; Akkus, Murat

doi:10.4067/s0717-95022023000200368

Int. J. Morphol.

2023

DOI: 10.4067/s0717-95022023000200368

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Investigation of the Protective Effect of Boric Acid Against Hepatotoxic and Nephrotoxic Injury Induced by Acrylamide in Rats

Ercan Gündüz

Eda YİLDİZHAN

Mine Yaman

et al.

Abstract: Investigation of the protective effect of boric acid against hepatotoxic and nephrotoxic injury induced by acrylamide in rats.

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Cited by 2 publications

References 19 publications

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Utilizing a Combination of Supplements Comprising Boric Acid, Magnesium, Vitamin D3, and Extra Virgin Olive Oil to Improve Metabolism in Menopausal Ovariectomized Rats

Atteia,

Ahmed,

Askar

et al. 2024

Biol Trace Elem Res

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Utilizing a Combination of Supplements Comprising Boric Acid, Magnesium, Vitamin D3, and Extra Virgin Olive Oil to Improve Metabolism in Menopausal Ovariectomized Rats

Atteia,

Ahmed,

Askar

et al. 2024

Biol Trace Elem Res

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Efficacy of Taxifolin in The Prevention of Renal Injury Due to Liver Ischemia and Reperfusion

ÜLGER,

AŞIR,

VARLI

et al. 2023

J Cukurova Anesth Surg

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Aim: During surgical procedures such as liver resection and transplantation, ischemia/reperfusion (I/R) injury and related complications may occur at a rate of approximately 10%. Our study, we planned to investigate histologically and biochemically the efficacy of Taxifolin in the prevention of renal tissue damage in liver ischemia reperfusion. Methods: A total of 28 Wistar Albino rats with an average age of 8-10 weeks and weights of 250-300 grams were used in our study. Group 1 (n=7): control group, Group 2 (n=7): Taxifolin group; Taxifolin was administered orally at a dose of 50 mg/kg for 3 weeks, Group 3 (n=7): Liver I/R group, 30 minutes ischemia and 120 minutes reperfusion was performed. Group 4 (n=7): Taxifolin+Liver I/R group. Results: Kidney tissues of the liver I/R group showed atrophy, degeneration of tubule epithelium and increased TNF-α expression. In addition, deterioration in renal function tests was also monitored in this group. In the Taxifolin+Liver I/R group, a significant difference was observed on both histologic and biochemical basis compared to the Liver I/R group and a positive effect was observed (p<0.05). Outcome: As a consequence of hepatic ischemia and reperfusion, impairment in the function and histological appearance of renal tissues was observed and Taxifolin was monitored to be effective in eliminating these adverse effects.

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Investigation of the Protective Effect of Boric Acid Against Hepatotoxic and Nephrotoxic Injury Induced by Acrylamide in Rats

Abstract: Investigation of the protective effect of boric acid against hepatotoxic and nephrotoxic injury induced by acrylamide in rats.

Cited by 2 publications

References 19 publications

Utilizing a Combination of Supplements Comprising Boric Acid, Magnesium, Vitamin D3, and Extra Virgin Olive Oil to Improve Metabolism in Menopausal Ovariectomized Rats

Utilizing a Combination of Supplements Comprising Boric Acid, Magnesium, Vitamin D3, and Extra Virgin Olive Oil to Improve Metabolism in Menopausal Ovariectomized Rats

Efficacy of Taxifolin in The Prevention of Renal Injury Due to Liver Ischemia and Reperfusion

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