Investigation of the Relationship Between IL-18 (− 607 C/A), IL-18 (− 137 G/C), and MMP-2 (− 1306 C/T) Gene Variations and Serum Copper and Zinc Levels in Patients Diagnosed with Chronic Renal Failure

Ay, Arzu; Alkanlı, Nevra; Üstündağ, Sedat

doi:10.1007/s12011-021-02828-6

Cited by 6 publications

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The World Health Organization (WHO) has recommended that the copper concentration in drinking water should be maintained in the range of 0.05 to 3 mg/L. As people's standard of living improves, the risk of exposure to copper toxicity increases every year, and many studies have con rmed that copper disorders in the body are associated with neurodegenerative 7 , metabolic 8 , and renal diseases 9,10 , and effective prevention and mitigation of copper toxicity is therefore urgent.…”

Section: Introductionmentioning

confidence: 99%

Metabolomic changes in mice induced by copper exposure: systematic analysis and exploration of toxicity mechanisms

Xiao,

Gong,

Zhao

et al. 2024

Preprint

View full text Add to dashboard Cite

Copper, an essential trace element, is indispensable for the growth and physiological functions of living beings, influencing several critical processes like cellular energy production, antioxidant defense, communication within cells, and functioning of enzymes. However, when copper levels exceed normal limits, it can lead to significant health issues. Recent investigations into the adverse effects of copper have shed light on its toxicological impacts, particularly focusing on metabolic alterations in certain organs. Yet, comprehensive research that examines the primary organs at risk from copper toxicity through a metabolomic lens remains scarce. In this study, an untargeted metabolomics strategy was adopted to assess how copper exposure alters organ metabolites leveraging gas chromatography-mass spectrometry (GC-MS) with the aim of identifying possible biomarkers and investigating their association with metabolic pathway disorders. Male C57BL/6J mice were randomly assigned to different experimental groups and metabolite levels in different organs were measured using GC-MS. Analyses showed very different metabolite profiles between groups, with 11, 32, 12, 18, 16, 15, 9, and 27 metabolites identified and 14 metabolites altered in serum, liver, kidney, muscle, hippocampus, cortex, lung, and pancreas, respectively, and examined the relationship between metabolites and metabolic pathways. Our findings reveal that copper is closely associated with disruption of metabolic pathways, and that copper can trigger a wide range of toxic effects through multiple pathways, such as triggering oxidative stress, interfering with mitochondrial function, altering enzyme function, weakening the body's ability to detoxify, and interfering with cell signaling. These findings reveal the complex mechanisms of copper toxicity and provide valuable information for the development of preventive and therapeutic measures for copper toxicity.

show abstract

Section: Introductionmentioning

confidence: 99%

Metabolomic changes in mice induced by copper exposure: systematic analysis and exploration of toxicity mechanisms

Xiao,

Gong,

Zhao

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Copper in Human Health and Disease: A Comprehensive Review

Binesh,

Venkatachalam

2024

J Biochem & Molecular Tox

View full text Add to dashboard Cite

This comprehensive review discusses the crucial role of copper in human health and disease as an essential trace mineral. It emphasizes the significance of copper while addressing potential risks from imbalances in copper levels, be it excessive or inadequate. The review outlines various challenges in copper research, including toxicity concerns, data limitations, metabolic complexities, genetic influences, nutrient interactions, and resource constraints. Despite these challenges, the review identifies specific research areas needing exploration, such as copper homeostasis regulation, transport mechanisms, gut microbiome interactions, immune function, neurodegenerative diseases, cardiovascular health, cancer, fertility, and reproductive health. The purpose of this review is to explore the important role of copper in human health and disease, which highlights the delicate balance required to avoid deficiency or toxicity. For the researchers and scientists, it provides the gaps in the research, so it aims to provide insights that could advance diagnostic and therapeutic strategies across various medical disciplines.

show abstract

Investigation of the relationship between MMP-1 (− 1607 1G/2G), MMP-3 (− 1171 5A/6A) gene variations and development of bladder cancer

Alkanlı

Çevik

2021

Mol Biol Rep

View full text Add to dashboard Cite

Investigation of the Relationship Between IL-18 (− 607 C/A), IL-18 (− 137 G/C), and MMP-2 (− 1306 C/T) Gene Variations and Serum Copper and Zinc Levels in Patients Diagnosed with Chronic Renal Failure

Cited by 6 publications

References 37 publications

Metabolomic changes in mice induced by copper exposure: systematic analysis and exploration of toxicity mechanisms

Metabolomic changes in mice induced by copper exposure: systematic analysis and exploration of toxicity mechanisms

Copper in Human Health and Disease: A Comprehensive Review

Investigation of the relationship between MMP-1 (− 1607 1G/2G), MMP-3 (− 1171 5A/6A) gene variations and development of bladder cancer

Contact Info

Product

Resources

About