INVESTIGATION OF THE RELATIONSHIP BETWEEN Β2-Adrenergic RECEPTOR (Β2-Ar) POLYMORPHISM AND GASTRİC CANCER

Abstract

Gastric cancer is a multifunctional disease. Emotional stress, physiological and neuroendocrine changes in cancer patients can lead to the activation of the hypothalamic-pituitary-adrenal axis and the release of hormone dependent hormones such as catecholamine. In particular, it has been reported that catecholamine induction directly affects the biological behavior of tumor cells via β2-Adrenergic receptor (β2-AR) mediated signaling. In this study, it was aimed to investigate polymorphism of β2-AR gene (rs1042717) in gastric cancer patients. Method: Polymorphism in the β2-AR gene (rs1042717) was determined by Real-Time PCR method in 60 gastric cancer patients and 50 healthy controls. The results were evaluated using logistic regression and Chi-square (χ2) test. Results: The comparison of gastric cancer patients and controls determined a statistically significant relationship for alcoholic drink consumption (p<0,05). There was a statistically significant relationship between β2-AR (rs1042717) polymorphism and stomach cancer (p <0.05). There was a statistically significant relationship between mutant (AA) genotype with wild type (GG) and heterozygous (AG) polymorphic genotypes when evaluated in β2-AR polymorphism gastric cancer patients and control group (χ2: 19,38, p: 0.001). Similarly, there was a statistically significant correlation between heterozygous (AG) with wild type (GG) and mutant (AA) polymorphic genotypes in gastric cancer (χ2: 14, 27, p: 0,001). Conclusions: In this study, it was found that the AG genotype is predominant in gastric cancer patients and controls, and that the AA genotype has a protective effect against gastric cancer.

Investigation of the relationship between exportın5 (XPO5) polymorphism and gastric cancer

“…20 The current understanding of genetic polymorphism and GC development is largely based on studies conducted in Asian and Caucasian populations. 21 Many studies have revealed that GC risk is associated with polymorphisms in genes involved in DNA synthesis and repair, inflammatory response, metabolic enzymes, and oxidative damage. 22 Human miRNA biogenesis is processed inside the nuclues and cytoplasm as a step wise.…”

“…This result agreement with the previous report done by scholars. 21 Beside to this, GC patients and control subjects were evaluated by logistic regression analysis for smoking habits. No statistically significant difference was identified between GC patients and smoking habits in the Turkish population investigated in the current study (p=0.201, Table 3).…”