Investigation of the serum oxidative stress in broilers fed on diets supplemented with nickel chloride

Abstract

<span style="font-size:10.0pt;font-family:""><span style="font-family:Verdana;">The purpose of this study was to investigate the serum oxidative stress induced by dietary nickel chloride (NiCl</span>_{<span style="font-family:Verdana;">2</span>}<span style="font-family:Verdana;">) in broilers. A total of 240 one-day-old avian broilers were divided into four groups and fed on a cornsoybean basal diet as control diet or the same basal diet supplemented with 300 mg/kg, 600 mg/kg and 900 mg/kg NiCl</span>_{<span style="font-family:Verdana;">2</span>}<span style="font-family:Verdana;">. During the experimental period of 42 days, oxidative stress parameters were de</span><span style="font-family:Verdana;">termined for both control and experimental groups. The results showed that malondialdehyde (MDA) content was significantly higher (p < 0.05 or p < 0.01) in the 300 mg/kg, 600 mg/kg and 900 mg/kg groups than that in the control group. In contrast, the activities of superoxide dismu- tase (SOD), catalase (CAT) and glutathione per- oxidase (GSH-Px), and the ability to inhibit hy- droxy radical, and glutathione hormone (GSH) content were significantly decreased (p < 0.05 or p < 0.01) in the 300 mg/kg, 600 mg/kg and 900 mg/kg groups in comparison with those of the control group. It was concluded that dietary NiCl</span>_{<span style="font-family:Verdana;">2</span>}<span style="font-family:Verdana;"> inexcess of 300 mg/kg could cause oxidative stress, which could finally impaired the an</span><span style="font-family:Verdana;">tioxidant function in broilers.</span></span

Dietary Nickel Chloride Induces Oxidative Intestinal Damage in Broilers

“…In agreement with results of the abovementioned studies, our data suggested that dietary NiCl2 caused the intestinal oxidative damage in broilers, which showed a dose and time dependent increase of MDA contents, and decrease of GSH-Px, SOD, CAT activities and GSH contents, ability to inhibit hydroxy radical in the intestines (duodenum, jejunum and ileum). The same results were observed in the serum oxidative stress in broilers fed on diets supplemented with NiCl 2 in our early studies [34]. …”

Nickel Chloride (NiCl2) Induces Histopathological Lesions via Oxidative Damage in the Broiler’s Bursa of Fabricius

“…Our previous studies have also shown that dietary NiCl 2 in excess of 300 mg/kg causes splenic, intestinal, cecal tonsil, renal, and thymic oxidative damage and/or lesions [18][19][20][21][22]. It is also showed that NiCl 2 in excess of 300 mg/kg causes serum oxidative stress in broilers in our previous study [23].…”

Lipid oxidation in meat: mechanisms and protective factors – a review

“…Dther trace elements such as copper and nickel at doses higher than 200 and 300 mg/kg, respectively, have pro-oxidant effect on chicken meat (Wu et al, 2013).…”