Investigation of the solubility enhancement mechanism of rebaudioside D using a solid dispersion technique with potassium sorbate as a carrier

Pang, Shintaro; Ma, Changchu; Zhang, Naijie; He, Lili

doi:10.1016/j.foodchem.2014.11.113

Cited by 21 publications

(13 citation statements)

References 23 publications

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“…Comparatively, the solubility of the final products was reinforced, ranging from 84.01-97.50 for OD 60-40 and SD 80-20 samples, respectively, while non-encapsulated SGs solubility value was 62.64%. Similar observation regarding the enhancement of solubility of steviol glycoside (Rebaudioside D) using spray drying was also reported by Pang, Ma, Zhang, and He (2015).…”

Section: Study Of the Steviol Glycosides (Sgs) Products' Propertiessupporting

confidence: 85%

Comparison of spray, freeze and oven drying as a means of reducing bitter aftertaste of steviol glycosides (derived from Stevia rebaudiana Bertoni plant) – Evaluation of the final products

2016

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Section: Study Of the Steviol Glycosides (Sgs) Products' Propertiessupporting

confidence: 85%

Comparison of spray, freeze and oven drying as a means of reducing bitter aftertaste of steviol glycosides (derived from Stevia rebaudiana Bertoni plant) – Evaluation of the final products

2016

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“…On coming in contact with the aqueous medium, the polymer helps the drug to attain sufficient wettability and consequently enhanced solubility. The results are in accordance with published literature where improved solubility profiles of low soluble drugs have been attained with solid dispersions [29][30][31][32][33] .…”

Section: Discussionsupporting

confidence: 92%

Formulation development and systematic optimization of stabilized ziprasidone hydrochloride capsules devoid of any food effect

Banerjee

Prasad

2015

Pharmaceutical Development and Technology

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“…However, one drawback of STV's application as medicine could be its low solubility and low bioavailability 13 . At present, methods to improve the solubility of STV include: solid dispersion technology 14 , 15 , the use of enzymes such as transglycosylase to improve solubility through regioselective enzymatic glycosylation 16 , 17 , 18 , 19 , complexation with γ -cyclodextrin ( γ -CD) 20 , etc. There was no report on using the cyclodextrin metal-organic framework (CD-MOF) encapsulation of STV.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous improvement to solubility and bioavailability of active natural compound isosteviol using cyclodextrin metal-organic frameworks

Chen

Guo

Zhang

et al. 2021

Acta Pharmaceutica Sinica B

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Cyclodextrin metal-organic framework (CD-MOF) as a highly porous supramolecular carrier could be one of the solutions to the insolubility of isosteviol (STV). The solubility of STV was lower than 20.00 ng/mL at pH 1.0 and pH 4.5, whilst its solubility increased to 20,074.30 ng/mL at pH 6.8 and 129.58 ng/mL in water with a significant pH-dependence. The in vitro release profiles of STV from STV@CD-MOF (0.5:1) were pH-independent in distinct pH media and closed to be thoroughly released but no such release profiles were observed for STV@CD-MOF (1:1) owing to nanoclusters formation. The bioavailability of STV@CD-MOF (1:1) in rats was 8.67-fold higher than that of STV, and was 1.32- and 1.27-fold higher than that of STV@CD and STV@CD-MOF (0.5:1). Our results indicated that the inclusion mechanism played a primary role when STV in CD-MOF was at a low loading ratio, while the increasement in bioavailability at a high loading ratio, which was attributed to the nanocluster mechanism. This was confirmed by molecular simulation. In conclusion, CD-MOF is a promising system for STV loading, overcoming the insolubility and to improve the bioavailability of this natural compound.

show abstract

Investigation of the solubility enhancement mechanism of rebaudioside D using a solid dispersion technique with potassium sorbate as a carrier

Cited by 21 publications

References 23 publications

Comparison of spray, freeze and oven drying as a means of reducing bitter aftertaste of steviol glycosides (derived from Stevia rebaudiana Bertoni plant) – Evaluation of the final products

Comparison of spray, freeze and oven drying as a means of reducing bitter aftertaste of steviol glycosides (derived from Stevia rebaudiana Bertoni plant) – Evaluation of the final products

Formulation development and systematic optimization of stabilized ziprasidone hydrochloride capsules devoid of any food effect

Simultaneous improvement to solubility and bioavailability of active natural compound isosteviol using cyclodextrin metal-organic frameworks

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