Investigation of the synergism between alcohol consumption and herpes simplex virus in patients with laryngeal squamous cell cancers

Abstract

We investigated the synergism between alcohol consumption and herpes simplex virus (HSV) in the development of laryngeal squamous cell cancer and in the clinical course of this disease. HSV DNA was searched by polymerase chain reaction (PCR) technique in the fresh tumor tissues of 22 patients with laryngeal cancer without alcohol consumption (Group 1) and of 23 patients with chronic alcohol consumption (Group 2), and their HSV prevalences were compared. No statistically significant difference was detected between the two groups in terms of HSV incidence frequency (P > 0.05), but the risk of finding HSV in tumor tissue in patients with alcohol consumption history was 3.4-fold higher than in those without alcohol consumption history (OR = 3.378, 95% CI = 0.762-14.982). There were no statistically significant differences in terms of lymph node metastasis, tumor localization, tumor diameter, tumor stage and tumor differentiation between the patients in Group 1 and Group 2 (P > 0.05). Larger case series will further elucidate the role of HSV in the development of laryngeal cancer, the nature of its interactions with other carcinogens and its effect on the clinical course.

Does Epstein-Barr virus infection have an influence on the development of laryngeal carcinoma? Detection of EBV by Real-Time Polymerase Chain Reaction in tumour tissues of patients with laryngeal carcinoma

“…The role of many factors, especially tobacco use and alcohol consumption, has been clearly shown in the development of laryngeal carcinoma. Also it is known that certain viruses have oncogenic potentials, and the relationship between laryngeal carcinoma and viruses has been a popular subject of research for many years 2 , 3 , 4 .…”

Correlation of Histopathological Types of Laryngeal and Nasopharyngeal Mass with PCR Detected Epstein - Barr virus (LMP-1) – A Hospital Based Prospective Study

“…The role of many factors, especially tobacco use and alcohol consumption has been clearly shown in the development of laryngeal carcinoma. Also it is known that certain viruses have oncogenic potentials, and the relationship between laryngeal carcinoma and viruses has been a popular subject of research for many years [3][4][5]. The Epstein-Barr virus (EBV) has long been related to nasopharyngeal carcinoma [6].…”

Impact of Viral Infection on Effectiveness of Antitumor Treatment for Laryngeal Cancer

“…Уже имеются работы, подтверждающие наличие ДНК и маркера латентной инфекции вируса Эпштейна -Барр LMP-1 в опухолевых клетках при ПРГ и сопряженность его с повышением уровня АТ к белкам литической инфекции ВЭБ [16][17][18]. Имеются данные о несомненном присутствии в ткани опухоли гортани и других представителей герпесвирусов - вируса простого герпеса 1 и 2 типов (ВПГ-1, 2), цитомегаловируса (ЦМВ) и вируса герпеса человека 6 типа (ВГЧ-6) [17][18][19][20].…”