Investigation of the Wound Healing Activity ofCarapa guianensisL. (Meliaceae) Bark Extract in Rats Using Excision, Incision, and Dead Space Wound Models

Abstract

The objective of our study is to investigate the wound healing activity of the bark extract of Carapa guianensis in rats using three different wound models. The animals were randomly divided into two groups of six each in all the models. Test group animals were treated topically with the bark extract (200 mg/kg of body weight), and the controls were treated with petroleum jelly in the excision wound model. In the incision and dead space wound models the test group animals were treated with the extract of C. guianensis (200 mg/kg/day) orally by mixing in drinking water, and the control group animals were maintained with plain drinking water. Healing was assessed by the rate of wound contraction, period of epithelialization, skin breaking strength, granulation tissue weight, and hydoxyproline content. Antimicrobial activities of the extract against the microorganisms were also assessed. On day 15 extract-treated animals exhibited 99% reduction in the wound area compared to controls (93%). The extract-treated wounds were found to epithelialize faster than controls (P < .02). The skin breaking strength was significantly higher in extract-treated animals compared to controls (P < .001). The weight and hydroxyproline content of granulation tissue were significantly increased compared to controls. These observations support the use of C. guianensis is in the management of wound healing.

Revisiting Amazonian Plants for Skin Care and Disease

“…In another study, conducted on patients subjected to inguinal hair removal with pulsed light, the oil emulsion has induced analgesic and anti-inflammatory effects comparable to those of desonide alone [38]. The wound healing activities of the ethanolic extracts of leaves and bark have been observed in studies on rats [39,40].…”

“…Seed oil Wound healing, insect repellent, anti-psoriasis [36] Seed oil Emollient, hydrating, firming, depigmenting, rejuvenating [42] Seed oil Glucose-6-phosphate dehydrogenase inhibition [43] Seed oil/desonide emulsion Burn healing, analgesic, anti-inflammatory [37,38] Leaf ethanolic extract Wound healing [39,40] Limonoids Lenitive [42] …”

The effect of andiroba oil and chitosan concentration on the physical properties of chitosan emulsion film

“…Many studies have reported the pharmacological properties of products obtained from the andiroba flower [1,2] , from the ethanolic extract of the andiroba leaf [3,4] and especially products derived from andiroba seed oil [5][6][7] . Andiroba oil is widely used in popular medicine in the Amazon basin region.…”

“…Andiroba oil also contains triterpenes, tetraterpenes, alkaloids, and glycerides [9] . Andiroba seed oil is currently considered to be acaricides [10] , larvicidal against Aedes aegypti [11] , as well as being an antiplasmodial [5] , anti-inflammatory [12] , anti-allergic [7,13,14] , and also suitable for wound healing [3,4] . The ethanolic extract of Carapa guianensis leaves was evaluated for antibacterial and wound healing activity, using excision, incision, and dead space wound models in rats.…”

Efeito de Schinus terebinthifolius Raddi (aroeira) e Carapa guianensis Aublet (andiroba) na cicatrização de gastrorrafias

“…The traditional process of extracting oil from the seeds of andiroba begins with the collection and selection of them, cooking for 1-3 h in water, kneading the seeds and placing the dough in sloping surface and leaving the oil drip 18 . In this oil we highlight the anti-inflammatory activity, antiparasitic, repellents, healing activity, anti-allergic, anti-toxic at the immature stage of mosquitoes Aedes aegypti 8,22,26 . The aim of this study is to analyze the healing effect of hydro alcoholic extract of aroeira and andiroba oil via orogastric in gastrorraphies in rats, through histological and tensiometric analysis.…”