The present work aims to investigate thermal performance of a solar flat plate collector using water and Cu-MWCNTs nanoparticle-based hybrid nanofluid both experimentally and numerically. X-Ray diffraction, FESEM with EDAX mapping were performed to characterize nanoparticles. The experimental setup was developed for thermal performance of FPC varying flow rates (0.5, 1.0, 1.5 lpm), inclination angle (25°, 30°, 35°, 40°, 45°), volume concentration (0 %, 0.1 %, 0.2 %, 0.3 %, 0.4 %) and intensity (400 W/m 2 ). The 3D numerical model having similar geometry as of actual flat plate collector was modeled using Fluents 15.0. The SST turbulence model was used to capture the chaotic changes in the velocity, temperature, and pressure fields. The experimental findings revealed 79.74% improvement in instantaneous efficiency at 0.4% vol., 1.5 lpm, 45° inclination angle, and 400 W/m 2 intensity. The maximum deviation between the experimental and numerically calculated outlet and inlet temperature difference (ΔT) was 3.5% using a hybrid nanofluid.When numerical data are compared, instantaneous efficiency and heat gain both deviate by 2.8% and 2.9% from experimental values. Because of the numerical simulation analysis, it is possible to observe the temperature and flow pattern in flat plate collectors using nanofluids under a set of operating conditions, which would not be possible without the simulation.