Investigation of UV light treatment (254 nm) on the reduction of aflatoxin M1 in skim milk and degradation products after treatment

Nguyen, Thu Trang; Palmer, John W.; Loo, Trevor S.; Shilton, Andy; Petcu, Miruna; Newson, Harriet L.; Flint, Steve

doi:10.1016/j.foodchem.2022.133165

Cited by 24 publications

(7 citation statements)

References 39 publications

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“…LC–MS analysis was conducted to further study the degradation products of AFM 1 [ 25 ]. A total ion flow diagram in positive ion mode is shown in Figure S2 (Supplementary file) , where only one obvious chromatographic peak was observed.…”

Section: Resultsmentioning

confidence: 99%

“…Nikmaram et al inferred that the construction of degradation products appeared to possess less toxicity than that of AFM 1 because of the absence of a C8–C9 double bond and decoration of the furan ring [ 27 ]. Nguyen et al reported the removal of the furan ring structure to form degradation products, which may have decreased the toxicity of these products compared to AFM 1 [ 25 ]. Few studies have been carried out to experimentally analyze the toxicity of degradation products.…”

Section: Resultsmentioning

confidence: 99%

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Degradation Mechanism of Aflatoxin M1 by Recombinant Catalase from Bacillus pumilusE-1-1-1: Food Applications in Milk and Beer

Liu,

Zhao,

Wang

et al. 2024

Foods

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A bacteria capable of degrading aflatoxin M1 (AFM1) was isolated from African elephant manure. It was identified as Bacillus pumilus by 16s rDNA sequencing and named B. pumilusE-1-1-1. Compared with physical and chemical methods, biological methods have attracted much attention due to their advantages, such as thorough detoxification, high specificity, and environmental friendliness. This work aimed to study the effects of a recombinant catalase (rCAT) from B. pumilusE-1-1-1 on the degradation of AFM1 in pattern solution. The degradation mechanism was further explored and applied to milk and beer. Kinetic Momentum and Virtual Machine Maximum values for rCAT toward AFM1 were 4.1 μg/mL and 2.5 μg/mL/min, respectively. The rCAT-mediated AFM1 degradation product was identified as C15H14O3. Molecular docking simulations suggested that hydrogen and pi bonds played major roles in the steadiness of AFM1–rCAT. In other work, compared with identical density of AFM1, survival rates of Hep-G2 cells incubated with catalase-produced AFM1 degradation products increased by about 3 times. In addition, degradation rates in lager beer and milk were 31.3% and 47.2%, respectively. Therefore, CAT may be a prospective substitute to decrease AFM1 contamination in pattern solution, milk, and beer, thereby minimizing its influence on human health.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Degradation Mechanism of Aflatoxin M1 by Recombinant Catalase from Bacillus pumilusE-1-1-1: Food Applications in Milk and Beer

Liu,

Zhao,

Wang

et al. 2024

Foods

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“…Fortunately, it is clearly evident that UV radiation therapy has been proven to eliminate AFB 1 levels in a variety of food items, such as corn grit, black pepper, nuts, peanuts and milk (Shen & Singh, 2021; Nguyen et al ., 2022). Among the new treatment technologies for mycotoxins decontamination, UV light treatment might be one of the most effective, environmentally friendly and sustainable treatment technologies (Faraji et al ., 2022).…”

Section: Introductionmentioning

confidence: 99%

UV light treatment (278 nm) for detoxification of aflatoxins and application in edible and medicinal herb coix seed

Zou,

Sun,

et al. 2024

Int J of Food Sci Tech

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SummaryAflatoxins (AFs) are highly toxic and cancer‐causing compounds, which could be commonly found in agricultural products and feeds. However, different tactics for detoxification have significant limitations due to their unsuitability for use. In this study, an LED UV curing system (wavelength: 278 nm, irradiation energy: 100%, irradiation time: 10 min) could effectively reduce pure aflatoxin B1 (AFB1), pure aflatoxin B2 (AFB2) and pure aflatoxin G1 (AFG1) (detoxification rates are more than 80%). In addition, in vitro biocompatibility tests indicate that the hypertoxicity of the obtained AFs‐degraded solutions was significantly reduced, which might be because the unsaturated ketone structure in AFB1, AFB2 and AFG1 was broken. Moreover, in processed coix seed and dried boat‐fruited Sterculia seed samples, the amount of AF was greatly reduced, and the rate of degradation was more than 85% with irradiation for 30 min. These data adequately implied that the current work might offer a practical way to detoxify AFs in various medicinal plants and foods.

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“…Therefore, when subjected to various heat treatments, these were not efficient for the degradation of these mycotoxins. However, the literature describes the ability of an optical source such as light emitting diode (LED) to decrease the concentration of AFM1 in milk samples as a promising alternative for the reduction of AFL in contaminated food (Nguyen et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

UV LED Light Efficiency in Aflatoxin M1 Reduction in Bovine Milk

Kluczkovski

Goes²,

Santos³

et al. 2023

JAS

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Bovine milk is a food consumed by people of different age groups and especially by children, as it provides essential nutrients to the diet. In Brazil, milk is one of the most important products of Brazilian agriculture, being essential in the generation of employment and income. However, when there is contamination by toxic agents, such as aflatoxin (AFL) which is carcinogenic to humans and animals, there is a risk to the health of the consumer. Therefore, the objective of this work was to analyze the efficiency of the application of UV LED light as a tool to reduce aflatoxin M1 (AFM1) in bovine milk produced in the state of Amazonas, Brazil. Concerning time in 3-, 6- and 9-minutes, the reduction rates of 75.5, 97.3, and 94.1% were observed, respectively. The use of UV LED light was effective in reducing the concentration of AFL studied to be evaluated on a production scale.

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Investigation of UV light treatment (254 nm) on the reduction of aflatoxin M1 in skim milk and degradation products after treatment

Cited by 24 publications

References 39 publications

Degradation Mechanism of Aflatoxin M1 by Recombinant Catalase from Bacillus pumilusE-1-1-1: Food Applications in Milk and Beer

Degradation Mechanism of Aflatoxin M1 by Recombinant Catalase from Bacillus pumilusE-1-1-1: Food Applications in Milk and Beer

UV light treatment (278 nm) for detoxification of aflatoxins and application in edible and medicinal herb coix seed

UV LED Light Efficiency in Aflatoxin M1 Reduction in Bovine Milk

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