Investigation of vitamin D levels in patients with Sudden Sensory-Neural Hearing Loss and its effect on treatment

Ghazavi, Hossein; Kargoshaie, Amir-Abbas; Jamshidi-Koohsari, Mohammad

doi:10.1016/j.amjoto.2019.102327

Cited by 21 publications

(14 citation statements)

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“…Many of them are linked with vitamin D deficiency [ 13 , 15 , 18 ]. For example, the prevalence of vitamin D deficiency is higher in patients with sudden sensorineural hearing loss (SSNHL) than healthy individuals and SSNHL patients with deficient vitamin D had the highest percentage of no response to treatment [ 20 ]. Additionally, in humans, vitamin D deficiency has been associated with bilateral sensorineural hearing loss, possibly by interfering with the calcium metabolism and microcirculation in the cochlea [ 16 , 33 ].…”

Section: Resultsmentioning

confidence: 99%

“…Regarding the presence of vitamin D receptors in the inner ear, one should expect that vitamin D deficiency may influence vestibular and auditory function [16,17]. In fact, recent studies have reported the high prevalence of vitamin D deficiency in patients with inner ear diseases, including benign paroxysmal positional vertigo, Menière's disease, vestibular neuritis, idiopathic facial paralysis, and idiopathic acute hearing loss [18][19][20]. The role of vitamin D in the inner ear diseases may be related to calcium metabolism, fluids, and nerve transmission impairment leading to the degeneration of auditory structures, demineralization of the cochlea, cochlear sensitivity to chronic ischemic effects, and lysosomal enzymes imbalance [16,17,20].…”

Section: Introductionmentioning

confidence: 99%

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The role of vitamin D in subjective tinnitus—A case-control study

et al. 2021

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Regarding the high prevalence of vitamin D (25(OH)D) deficiency in the population and its possible association with ear diseases, we aimed to investigate the 25(OH)Dserum level in patients with subjective, nonpulsating tinnitus and its effect on tinnitus severity. The study included 201 tinnitus patients and 99 controls. Patient clinical information, including tinnitus characteristics and severity according to Tinnitus Handicap Inventory (THI), loudness assessed by Visual Analogue Scale (VAS), audiometry, and the blood level of vitamin D, was recorded. The level of 25(OH)D in tinnitus patients was significantly decreased compared with the controls (19.86 ± 7.53 and 27.43 ± 8.85 ng/ml, respectively; P value < 0.0001). More patients in the tinnitus group were deficient in vitamin D, compared with the controls (50.7% vs. 22.2% respectively, p < 0.0001). Tinnitus patients with a lower serum level of 25(OH)D (≤15 ng/dl) were significantly younger, had a higher degree of tinnitus severity measured with THI and VAS scales, had higher triglyceride and TSH levels, and a lower HDL level compared with individuals who had higher 25(OH)D level (>15 ng/dl). There was a strong correlation between the 25(OH)D level and THI. Our findings suggest that a large proportion of tinnitus patients suffers from vitamin D deficiency and that the vitamin D level correlates with tinnitus impact. We recommend a vitamin D assessment for all tinnitus patients.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The role of vitamin D in subjective tinnitus—A case-control study

et al. 2021

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“…Szeto et al ( 35 ) analyzed the associations between 25(OH)D, PTH, total calcium, BMD, and hearing loss in 1,123 participants aged ≥70 years and found that 25(OH)D <20 ng/mL was the risk factors of low-frequency hearing loss (OR: 2.02, 95% CI: 1.28–3.19) and voice frequency hearing loss (OR: 1.96, 95% CI: 1.12–3.44), but not PTH and total calcium. Ghazavi et al ( 36 ) found that the average vitamin D level in the SSNHL group was 19.28 ± 9.56 ng/ml, which was significantly lower than that in the control group (25.71 ± 11.21 ng/ml, P < 0.001), and believed that adequate vitamin D levels were associated with good prognosis. In postmenopausal women, 25(OH)D levels decrease, and timely estrogen supplementation can promote the deposition of serum calcium into the bones ( 37 ).…”

Section: Discussionmentioning

confidence: 97%

Bone-turnover biomarkers as potential prognostic factors in sudden sensorineural hearing loss: A prospective cohort study

et al. 2022

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ObjectivesThis study aims to explore the relationship between bone-turnover biomarkers and the recovery of SSNHL to provide clues for further improvements in etiological research and predictors.MethodsThe medical history, hearing thresholds, biomarkers of bone-turnover, and related hormones of 117 SSNHL patients were collected prospectively between August 2018 and December 2021. Linear correlation and logistic regression models were applied to examine the association between bone-turnover biomarkers and the prognosis of SSNHL.ResultsAge, the incidence of vertigo, pure tone average of the impaired frequencies (PTAimpairedfre), and the levels of bone turnover [including alkaline phosphatase (ALP), β-carboxy terminal crosslinked telopeptide of type 1 collagen (β-CTX), and N-terminal-midfragment of osteocalcin (N-MID)] were higher in the nonresponders than responders (P < 0.05). Logistic regression showed that the age (OR = 1.035, P = 0.027), time to treatment (OR = 1.157, P = 0.038), PTAimpairedfre (OR = 1.031, P = 0.008), and β-CTX (OR = 1.004, P = 0.001) were independent risk factors for the prognosis of SSNHL. In the women SSNHL subgroup, age, postmenopause percentage, PTAimpairedfre, the activity of ALP, levels of β-CTX, and N-MID were significantly higher in the nonresponders than the responders (P < 0.05). Compared to the men SSNHL subgroup, β-CTX has a higher correlation coefficient and predictive efficiency in the women SSNHL subgroup, and logistic regression showed that β-CTX (OR = 1.004, P = 0.004) was an independent risk factor for the women SSNHL.ConclusionsBone-turnover biomarkers are risk factors for poor prognosis in SSNHL, especially β-CTX. The differences were significant in women SSNHL, which may be related to the rapid regression of estrogen after menopause that leads to the occurrence of osteoporosis with a high conversion rate.

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“…5 There are also reports that the prevalence of vitamin D deficiency in patients with sudden sensorineural hearing loss is more than that in people with normal hearing. 6 Based on the lack of reports on the relationship between MD and vitamin D, there is a need for epidemiologic studies to evaluate their association. Therefore, the current study aimed to investigate the association between serum vitamin D levels and MD.…”

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confidence: 99%

Association Between Serum Vitamin D Level and Ménière’s Disease

Bakhshaee

Moradi²,

Mohebi

et al. 2021

Otolaryngol.--head neck surg.

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Objectives Ménière’s disease (MD) is a well-known inner ear disease; however, the etiopathogenesis is unknown. Several factors may be involved. Meanwhile, vitamin D is reported to have an important role in inner ear physiology. The aim of this study is to evaluate the relation between vitamin D deficiency and MD. Study Design This matched case-control study compared serum vitamin D levels between patients with definite MD and those without it. Setting The study was done between August 2018 and December 2019 at Ghaem University Hospital in Mashhad, Iran. Methods Twenty-eight patients with definite MD were matched with a group of 84 healthy individuals, regarding age, sex, body mass index, and occupation (indoor vs outdoor). The serum level of vitamin D (25-hydroxyvitamin D3) was measured in both groups. Results The mean ± SD vitamin D level was 18.9 ± 9.7 ng/mL in the case group and 25.2 ± 13.7 ng/mL in the control group ( P = .027). There was a significant difference between the case and control groups according to the results of the conditional logistic regression model ( P = .03; adjusted odds ratio, 0.96). In the MD group, 17 (60.7%) patients were vitamin D deficient, 6 (21.4%) insufficient, and only 5 (17.9%) sufficient. Conclusions The results of this study show that serum vitamin D level in MD is significantly lower than that of the control group. However, the role of vitamin D supplementation in the management of MD needs further study. Level of evidence: 4.

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Investigation of vitamin D levels in patients with Sudden Sensory-Neural Hearing Loss and its effect on treatment

Cited by 21 publications

References 30 publications

The role of vitamin D in subjective tinnitus—A case-control study

The role of vitamin D in subjective tinnitus—A case-control study

Bone-turnover biomarkers as potential prognostic factors in sudden sensorineural hearing loss: A prospective cohort study

Association Between Serum Vitamin D Level and Ménière’s Disease

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