Recently, the multitower suspension bridge has been widely used in long-span bridge construction. However, the dynamic response of the deck and pavement system of the multitower suspension bridge under random vehicle load is still not clear, which is of great significance to steel-bridge deck pavement (SBDP) design and construction. To reveal the mechanical mechanism of the steel-bridge deck pavement of the multitower suspension bridge under traffic load, this paper analyzed the mechanical response of the pavement based on case study through the multiscale numerical approach and experimental program. Firstly, considering the full-bridge effect of the multitower suspension bridge, the finite element model (FEM) of the SBDP composite structure was established to obtain key girder segments. Secondly, the influences of pavement layer, bending moment and torque, random traffic flow, and bridge structure on the stress of the girder segment were analyzed. Thirdly, the mechanical response of the pavement layer to the orthotropic plate under random vehicle load was studied. Finally, a full-scale model of the experimental program was established to verify the numerical results. Results show that (1) the pavement layer reduced the stress of the steel-box girder roof by about 10%. In the case of adverse bending moment and torque, the longitudinal and transverse stresses of the pavement layer were mainly concentrated in the stress concentration area near the suspender. Under the action of the random vehicle flow, the stress response of the pavement layer was increased by 40% compared with that under standard load. (2) Three-tower and two-span bridge structures have a great influence on the vertical deformation of the pavement layer under the action of vehicle load. Thus, the pavement material needs to have great deformation capacity. (3) The full-bridge effect has a significant influence on the longitudinal stress of the local orthotropic plate, but a small influence on the transverse stress. (4) There is a good correlation between the experimental measurement results of the full-size model and that of the numerical model. The research results can provide guidance for SBDP design and construction of the multitower suspension bridge.