Investigation of wound healing activity <i>Cynara</i><i>humilis</i> of root extracts

Salhi, Najoua; Bouyahya, Abdelhakim; Bounihi, Amina; Masrar, Azlarab; Bouabdellah, Mounia; Chabraoui, Layachi; Zengin, Gökhan; Taghzouti, Khalid; Rouas, L.; Cherrah, Y.

doi:10.1111/jocd.14237

Cited by 9 publications

(3 citation statements)

References 30 publications

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“…Inflammation can also aid in the production and degeneration of dermal cells. According to these facts, burn wounds, which are subject to a high level of inflammation and cannot be avoided, should be treated with anti-inflammatory and antioxidant drugs to reduce the risk of delayed wound healing [ 7 ]. As proven in our previous work [ 13 ], C. humilis has a variety of active compounds, each of which can operate as an antibacterial, anti-inflammatory, and powerful antioxidant.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the Wound Healing Potential of Cynara humilis Extracts in the Treatment of Skin Burns

Salhi

Guourrami

Rouas

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Cynara humilis is traditionally used to treat skin burns and microbial infections. However, experimental studies on this plant are rare. Furthermore, the aim of this study was to investigate the effects of Cynara humilis, a Moroccan herbal remedy, on the healing of deep second-degree burns in rats with a silver sulfadiazine group. This research was also carried out to confirm if C. humilis had antibacterial capabilities. Under typical burn procedures, each rat received a deep second-degree burn on the upper back. The burns were treated regularly with control groups (control and control VH), silver sulfadiazine (SDD) in group 3, C. humilis ethanolic extract (CHEE) in group 4, and C. humilis aqueous extract (CHAE) in group 5. Throughout the treatment, digital photography was used to measure rat responses to the treatment until day 18. After the scar biopsy at the end of the study, histological parameters (inflammatory cells, collagen, epithelialization, fibrosis, and granulation tissue) were assessed. Using the well technique, the antibacterial activity of the extracts was tested against Staphylococcus aureus CIP 483, Bacillus subtilis CIP 5262, Escherichia coli CIP 53126, Pseudomonas aeruginosa CIP 82118, and Salmonella enterica CIP 8039, and the results showed important activities of the ethanolic and aqueous extracts against the five species tested with MICs of 2 and 4 mg/mL, respectively. In the aqueous extract group, the wound healed faster. In addition, the healing rate in the C. humilis extracts (CHEA and CHEE) group was faster than in the silver sulfadiazine and control groups. In the C. humilis group, maximum wound surface recovery was observed at the same time, as it was not noted in the silver sulfadiazine group. Pathologically, epithelialization was more marked in wounds treated with C. humilis extracts (CHE). Angiogenesis and inflammatory cells were considerably lower in the CHE group than in the silver and other control groups. However, elastic fibers were considerable in the CHE-treated group. In histological examination, the C. humilis group had a low incidence of angiogenesis and inflammation, indicating that this group had less wound scarring. Collagen and burn wound healing were both faster in the C. humilis group. The findings of this study suggest that C. humilis, as indicated by traditional medicine, is a promising natural source for the management of wound healing.

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Section: Discussionmentioning

confidence: 99%

“…Certainly, the wound healing effect of medicinal plants is due to their diverse bioactive components such as terpenoids, flavonoids, tannins, and phenols. Herbal medicines had other advantages, including easy accessibility, fewer side effects, and low cost [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Wound Healing Potential of Cynara humilis Extracts in the Treatment of Skin Burns

Salhi

Guourrami

Rouas

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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“…Natural products have shown promising properties in the wound healing process through diferent mechanisms of action [4]. Extracts [5][6][7][8], essential oils [9,10], and secondary metabolites [11] isolated from medicinal plants were found to be efective.…”

Section: Introductionmentioning

confidence: 99%

Cedrus deodara: In Vivo Investigation of Burn Wound Healing Properties

Rastegari

Manayi

Akbarzadeh

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Objective. Cedrus deodara (Roxb. Ex Lamb.) G. Don possesses various biological activities, which have been documented in modern and traditional medicine. In this study, burn wound healing activity of the methanol extract of C. deodara wood was evaluated via a burn wound model in Wistar rats. Methods. The methanol extract of C. deodara was evaluated for the contents of phenolic compounds, flavonoids, and tannins. Also, its antioxidant activity was determined using the DPPH assay. Then, a topical ointment containing the methanol extract of C. deodara (10%) was used to evaluate the healing effects on a model of second-degree thermal burn in 4 groups of 7 rats within 21 days. In this respect, average wound surface area, wound closure, and various histological features were examined. Results. Our findings revealed that the wounds treated with the methanol extract of C. deodara showed higher wound contraction (33.6, 87.1, and 93.4% on days 7, 14, and 21, respectively) compared with the positive control (27.6, 80.7, and 88.3% on days 7, 14, and 21, respectively) and the negative control (20.1, 77.9, and 80.2% on days 7, 14, and 21, respectively). According to the results from epitheliogenesis score, the number of inflammatory cells, neovascularization, and collagen density, good burn wound healing activity of the methanol extract of C. deodarawas demonstrated. Conclusion. Using the methanol extract of C. deodara in an ointment formulation can be developed to prevent or reduce burn injury progression.

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