Investigation on fragmentation pathways of bisphenols by using electrospray ionization Orbitrap mass spectrometry

Zhao, Hongzhi; Li, Xiang; Li, Jiufeng; Yang, Zhiyi; Fang, Jing; Zhao, Changsui; Xu, Shunqing; Cai, Zongwei

doi:10.1002/rcm.7666

Cited by 41 publications

(28 citation statements)

References 33 publications

(65 reference statements)

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“…As illustrated in Figure 3, the m / z 113.0 peak was attributed to [M–2H] 2− , the m / z 227.0 peak was assigned to the deprotonated molecular ion [M–H] − , and the m / z 294.9 could be for dichlorobisphenol A [M–H] − [32]. The m / z 194.9 and 344.9 peaks could be for bisphenol AP and bisphenol P ([M–H–C 6 H 6 O] − and [M–H] − ) respectively, as the impurities [33]. There was a slight possibility that the m / z 194.9, m / z 294.9, and m / z 344.9 peaks arose from solvent contaminants or impurities.…”

Section: Resultsmentioning

confidence: 99%

Mass Spectrometric Analysis of Bisphenol A Desorption from Titania Nanoparticles: Ammonium Acetate, Fluoride, Formate, and Hydroxide as Chemical Desorption Agents

Majedi

Lai

2018

MPs

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Bisphenol A (BPA) is a widely used chemical in several consumer products and a well-studied environmental toxicant, and therefore, its accurate measurement is highly demanded. However, the co-presence of nanoparticles as an emerging class of contaminants could result in inaccurate determination of BPA due to binding of BPA onto nanoparticle surface. In this study, mass spectrometry (MS) was used to investigate desorption of BPA bound on the surface of titania (TiO2) nanoparticles in water. Ammonium acetate, fluoride, formate, and hydroxide were evaluated as chemical agents for their desorption capabilities. The percentages of recovery, adsorption, and desorption were determined by this new method without requiring any prior separation of nanoparticles from BPA. MS analysis demonstrated the desorption of BPA by 10–20 mM of ammonium hydroxide for a mixture of 5 µg/mL BPA and 10 µg/mL TiO2 nanoparticles, with a desorption efficiency of 72 ± 1%. Due to adsorption of BPA onto the nanoparticle surface that was inefficient for electrospray ionization, the resulting abundance of target ions could be reduced in the detection of BPA by mass spectrometry. As such, these findings collectively promise an accurate determination of the total BPA concentration in water whether it exists in the free or bound form. Efficient desorption of contaminants from the surface of nanoparticles would improve the accuracy of the contaminant analysis by mass spectrometry.

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Section: Resultsmentioning

confidence: 99%

Mass Spectrometric Analysis of Bisphenol A Desorption from Titania Nanoparticles: Ammonium Acetate, Fluoride, Formate, and Hydroxide as Chemical Desorption Agents

Majedi

Lai

2018

MPs

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“…These fragment ions are related to the losses of HF, 3HF, and HCF 3 , respectively. Some of the highlighted fragment ions obtained by HRMS 2 operating in CID mode are already reported in the literature, although they were acquired using higher energy collision dissociation (Zhao et al., ).…”

Section: Methodsmentioning

confidence: 99%

Are Canned Beverages Industries Progressively Switching to Bisphenol AF?

Russo

Varriale

Barbato

et al. 2019

Journal of Food Science

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“…The best separation was obtained in 4.5 min on a CSH C18 column, with retention times of 3.0 min and 2.5 min, for BPS and BPS-G, respectively. Two MRM transitions were optimized for each compound, namely 249>92 and 249>108 for BPS (corresponding to the loss of C6H5SO3 and C6H5SO2 respectively) [34], and 425>249 and 425>108 for BPS-G (loss of the glucuronide moiety and C6H5SO2, respectively).…”

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confidence: 99%

Development of an on-line solid phase extraction ultra-high-performance liquid chromatography technique coupled to tandem mass spectrometry for quantification of bisphenol S and bisphenol S glucuronide: Applicability to toxicokinetic investigations

Grandin

Picard‐Hagen

Gayrard

et al. 2017

Journal of Chromatography A

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Regulatory measures and public concerns regarding bisphenol A (BPA) have led to its replacement by structural analogues, such as Bisphenol S (BPS), in consumer products. At present, no toxicokinetic investigations have been conducted to assess the factors determining human internal exposure to BPS for subsequent risk assessment. Toxicokinetic studies require reliable analytical methods to measure the plasma concentrations of BPS and its main conjugated metabolite, BPS-glucuronide (BPS-G). An efficient on-line SPE-UPLC-MS/MS method for the simultaneous quantification of BPS and BPS-G in ovine plasma was therefore developed and validated in accordance with the European Medicines Agency guidelines for bioanalytical method validation. This method has a limit of quantification of 3ngmL for BPS and 10ngmL for BPS-G, an analytical capacity of 200 samples per day, and is particularly well suited to toxicokinetic studies. Use of this method in toxicokinetic studies in sheep showed that BPS, like BPA, is efficiently metabolized into its glucuronide form. However, the clearances and distributions of BPS and BPS-G were lower than those of the corresponding unconjugated and glucuroconjugated forms of BPA.

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Investigation on fragmentation pathways of bisphenols by using electrospray ionization Orbitrap mass spectrometry

Abstract: The MS/MS fragmentation pathways of nine bisphenols were, for the first time, systematically investigated with HRMS. The obtained data could be valuable for the identification of a variety of bisphenols in environmental and biological samples.

Cited by 41 publications

References 33 publications

Mass Spectrometric Analysis of Bisphenol A Desorption from Titania Nanoparticles: Ammonium Acetate, Fluoride, Formate, and Hydroxide as Chemical Desorption Agents

Mass Spectrometric Analysis of Bisphenol A Desorption from Titania Nanoparticles: Ammonium Acetate, Fluoride, Formate, and Hydroxide as Chemical Desorption Agents

Are Canned Beverages Industries Progressively Switching to Bisphenol AF?

Development of an on-line solid phase extraction ultra-high-performance liquid chromatography technique coupled to tandem mass spectrometry for quantification of bisphenol S and bisphenol S glucuronide: Applicability to toxicokinetic investigations

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