Investigation on ionical cross-linking of alginate by monovalent cations to fabrication alginate gel for biomedical application

Zhang, Yongli; Yang, Yi; Zhao, Xiaoxiang; Gao, Jianping

doi:10.1016/j.reactfunctpolym.2022.105484

Cited by 21 publications

(6 citation statements)

References 52 publications

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“…This was due to the neutralization of Ca 2+ with the negatively charged WPI, which weakened the electrostatic repulsive force between the droplets. Furthermore, the addition of Ca 2+ changed the bilayer emulsion from a uniformly dispersed droplet to a gel state (Figure 8E), which was due to the formation of alginate beads by the ionic cross-linking reaction between Ca 2+ and Na + in sodium alginate [51]. These results demonstrate that mono-and bilayer emulsions were not well tolerated to Ca 2+ .…”

Section: Effect Of Metal Ionic On the Emulsion Stabilitymentioning

confidence: 93%

Enhancing the Stability and Bioaccessibility of Tree Peony Seed Oil Using Layer-by-Layer Self-Assembling Bilayer Emulsions

Wang

et al. 2023

Antioxidants

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Tree peony seed oil (TPSO) is an important plant source of n-3 polyunsaturated fatty acid (α-linolenic acid, ALA > 40%) that is receiving increasing attention for its excellent antioxidant and other activities. However, it has poor stability and bioavailability. In this study, a bilayer emulsion of TPSO was successfully prepared using a layer-by-layer self-assembly technique. Among the proteins and polysaccharides examined, whey protein isolate (WPI) and sodium alginate (SA) were found to be the most suitable wall materials. The prepared bilayer emulsion contained 5% TPSO, 0.45% whey protein isolate (WPI) and 0.5% sodium alginate (SA) under selected conditions and its zeta potential, droplet size, and polydispersity index were −31 mV, 1291 nm, and 27%, respectively. The loading capacity and encapsulation efficiency for TPSO were up to 84% and 90.2%, respectively. It was noteworthy that the bilayer emulsion showed significantly enhanced oxidative stability (peroxide value, thiobarbituric acid reactive substances content) compared to the monolayer emulsion, which was accompanied by a more ordered spatial structure caused by the electrostatic interaction of the WPI with the SA. This bilayer emulsion also exhibited markedly improved environmental stability (pH, metal ion), rheological properties, and physical stability during storage. Furthermore, the bilayer emulsion was more easily digested and absorbed, and had higher fatty acid release rate and ALA bioaccessibility than TPSO alone and the physical mixtures. These results suggest that bilayer emulsion containing WPI and SA is an effective TPSO encapsulation system and has significant potential for future functional food development.

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Section: Effect Of Metal Ionic On the Emulsion Stabilitymentioning

confidence: 93%

Enhancing the Stability and Bioaccessibility of Tree Peony Seed Oil Using Layer-by-Layer Self-Assembling Bilayer Emulsions

Wang

et al. 2023

Antioxidants

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“…Furthermore, from the slight differences in the spectra of zinc alginate microparticles and those with encapsulated silver, it was not possible to unambiguously detect the formation of a bond between sodium alginate and silver ions. Lin et al [32] attributed the interaction of Ag + ions with the sodium alginate matrix to van der Waals interactions, while Zhang et al [33] showed that Ag + can also react electrostatically with anionic alginate, that is, under certain conditions, it is possible to gel alginate by ionic crosslinking with monovalent Ag + cations, similar to crosslinking with Ca 2+ cations.…”

Section: Identification Of Interactions Between Microparticle Constit...mentioning

confidence: 99%

Novel Zinc/Silver Ions-Loaded Alginate Microparticles: Synthesis, Physicochemical Properties, and Antifungal Activity Against <em>Botrytis cinerea</em>

Vinceković,

Jurić,

Vlahoviček-Kahlina

et al. 2023

Preprint

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Addressing the growing need for effective and environmentally friendly fungicides in agricul-ture, this study explored the potential of alginate microparticles loaded with metal ions as a novel approach to combat fungal pathogens. Novel alginate microparticles (microspheres and microcapsules) loaded with zinc or simultaneously with zinc and silver ions were prepared and physicochemically characterized (microparticle size, morphology, topography, encapsulation efficiency, loading capacity, and swelling behavior). Investigation of molecular interactions in microparticles using FTIR-ATR spectroscopy exhibited complex interactions between all con-stituents. Fitting to the simple Korsmeyer-Peppas empirical model revealed the rate-controlling mechanism of zinc and silver ions release from microparticles is Fickian diffusion. Lower values of the release constant k imply a slower release rate of Zn or Ag ions from microcapsules com-pared to that of microspheres. The antimicrobial potential of the new formulations against the fungus Botrytis cinerea was evaluated. When subjected to tests against the fungus, microspheres and microparticles loaded with both zinc and silver ions effectively reduced its growth and al-tered the fungal hyphal structures well as exhibited superior antifungal activity. The results showed the potential of these novel microparticles as potent fungicides in agriculture.

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“…Trata-se de um polissacarídeo aniônico natural, solúvel em água e originário de algas marinhas da família Phaeophyceae (Yang, Xie, He, 2011;Parreidt, Müller, Schmid, 2018). É considerado um excelente material para encapsulação por ser biocompatível, hidrofílico, biodegradável, inerte e apresentar grande disponibilidade no mercado (Zhang et al, 2023).…”

Section: Introductionunclassified

Development of Syzygium aromaticum (L.) essential oil encapsulates by ionic gelification and evaluation of antioxidant activity

Mergulhão,

Bulhões,

Silva

et al. 2024

CLIUM

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The objective of this work was to develop a product capable of protecting Syzygium aromaticum (clove) essential oil against high volatility. Clove oil (CEO) was encapsulated in alginate by ionic gelation with subsequent freeze-drying. Characterization was carried out by GC/MS, TGA/DSC and antioxidant (DPPH), and total phenol (Folin-Ciocalteau) analysis. Eugenol was the majority (81.5%) and the encapsulation efficiency varied between 14.0%+0.96 (F1: 1.0% alginate) and 9.8%+0.35 (F2: 2.0% alginate) in wet encapsulates, and 23.5%+0.14 (LF1: 1.0% alginate) and 16.9%+0.16 (LF2: 2.0% alginate) in freeze-dried encapsulates. The total phenol content reached 714.8+0.97 EAG g-1 in LF1, with strong inhibition of the DPPH radical (71.4%). Freeze-drying provided a higher percentage of active ingredients per gram of encapsulated and it was possible to identify high thermal stability in LF1 (mass loss: 81.8%; 258.9 °C) compared to wet encapsulates (mass loss: 86.5%; 65.8°C). The use of the lowest concentration of alginate seems to have been favorable. In this way, the accessible technology used allows preserving the content and properties of the CEO, offering a basis for new encapsulated research.

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Investigation on ionical cross-linking of alginate by monovalent cations to fabrication alginate gel for biomedical application

Cited by 21 publications

References 52 publications

Enhancing the Stability and Bioaccessibility of Tree Peony Seed Oil Using Layer-by-Layer Self-Assembling Bilayer Emulsions

Enhancing the Stability and Bioaccessibility of Tree Peony Seed Oil Using Layer-by-Layer Self-Assembling Bilayer Emulsions

Novel Zinc/Silver Ions-Loaded Alginate Microparticles: Synthesis, Physicochemical Properties, and Antifungal Activity Against <em>Botrytis cinerea</em>

Development of Syzygium aromaticum (L.) essential oil encapsulates by ionic gelification and evaluation of antioxidant activity

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