Investigation on the Porous Biomaterial for Bone Reconstruction with Addition of Bio-Mimetic Nano-Sized Inorganic Particles

Abstract

The spherical nano-sized bioactive particles in the system of CaO-P2O5-SiO2 were bio-mimetically synthesized using micro-emulsion method. The microstructures and properties of the bio- mimetic nano-materials were characterized using XRD, FTIR, SEM/EDAX and TEM techniques. It was indicated that the nano-particles possessed glassy structural characteristics. The porous composite for bone tissue reconstruction was prepared by compounding poly (hydroxybutyrate-2-co-2-hydroxyvalerate) (PHBV) and the nano-particles of bio-mimetic bioactive glasses (BMBG). Bone-like hydroxyl- carbonate-apatite (HCA) could formed on the surface of porous composite by immersing the composite in simulated body fluid (SBF) at 37°C for 8 hours. With increase of immersion time, the morphology of HCA changed from spherical into flake-like crystals. The study on cells attachment of the porous PHBV/BMBG composite proved that the material possessed satisfactory bioactivity, bio-mineralization function and cells biocompatibility.

Polymer/bioactive glass nanocomposites for biomedical applications: A review

“…9d). The study of cell attachment on the porous PHBV/BMBG composite indicated that the material has satisfactory bioactivity, bio-mineralization function and cell biocompatibility [88].…”

“…Zheng et al [88] have used another member of the PHA family, i.e. poly indicating that the composite contained a great amount of interconnected pores [88].…”

Preparation and Characterization of the Sol-Gel Derived Bioactive Glass-Fibers

“…For 77S fibers, the XRD pattern with a broad peak implied that the fibers were of amorphous solids (Fig. 2b (A)) [9]. SEM morphologies of 58S and 77S fibers before and after immersion in SBF were illustrated in Fig.…”

Bioactive Nanocomposites Containing Silicate Phases for Bone Replacement and Regeneration

“…It was also concluded that the higher specific surface area of NBG particles played a vital role in imparting the desired antimicrobial activity [61]. Zheng et al [62] developed composites using poly(hydroxybutyrate-2-co-2-hydroxyvalerate) (PHBV) containing biomimetically synthesized nanosized bioactive glass (BMBG) (CaO-P 2 O 5 -SiO 2 ). The porous composites were shown to be bioactive, and cell attachment studies indicated that the material has attractive biomineralization and cell biocompatibility [62].…”

“…Zheng et al [62] developed composites using poly(hydroxybutyrate-2-co-2-hydroxyvalerate) (PHBV) containing biomimetically synthesized nanosized bioactive glass (BMBG) (CaO-P 2 O 5 -SiO 2 ). The porous composites were shown to be bioactive, and cell attachment studies indicated that the material has attractive biomineralization and cell biocompatibility [62]. Composites combining poly(l-lactic acid) (PLLA) and sol-gel derived bioactive glass ceramic (BGC) nanoparticles were fabricated by Hong et al [56] using thermally induced phase separation.…”