Investigation the application of pristine graphdiyne (GDY) and boron-doped graphdiyne (BGDY) as an electronic sensor for detection of anticancer drug

Pang, Xu; Na, Na; Mohamadi, Ali

doi:10.1016/j.comptc.2020.112996

Cited by 34 publications

(24 citation statements)

References 33 publications

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“…The crystal structure models of Cur and CuS are shown in Figure S10b,c. The calculated adsorption energy between CuS and Cur was negative at −3.393 eV (Figure f), indicating an exothermic reaction of the bonding process and thus having a spontaneous bonding tendency between Cur and CuS . After bonding, the differential charge density (DCD) was shown in Figure g, which was utilized to illustrate the electrons transfer.…”

Section: Resultsmentioning

confidence: 92%

Photo-Sono Interfacial Engineering Exciting the Intrinsic Property of Herbal Nanomedicine for Rapid Broad-Spectrum Bacteria Killing

Liu

et al. 2021

ACS Nano

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Large doses and long duration are often required for herbal medicines to kill bacteria effectively. Herein, a photoacoustic interfacial engineering strategy was utilized to endow curcumin (Cur, a kind of herbal medicine) with rapid and highly effective bacteria-killing efficacy, in which Cur was combined with CuS to form a hybrid material of CuS/Cur with tight contact through in situ nucleation and growth on the petaloid CuS surface. Due to the different work functions of CuS and Cur, the interfacial electrons were redistributed, i.e., a large number of electrons gathered on the side of CuS. In contrast, the holes gathered on the side of Cur after contact. An internal electric field was formed to drive the excited electrons to transfer from CuS to Cur, thus enhancing the separation of electron−hole pairs. Besides exerting the drug nature of Cur itself, the CuS/Cur hybrid also had photo−sono responsive ability, which endowed the hybrid with photothermal, photodynamic, and sonodynamic effects. Therefore, this Cur-based hybrid killed 99.56% of Staphylococcus aureus and 99.48% of Escherichia coli under 808 nm near-infrared light irradiation and ultrasound successively for 15 min, which was ascribed to the synergy of ROS, hyperthermia, and released Cu 2+ together with the drug properties of Cur. This work provides a strategy to enhance the therapeutic effects of herbal medicines against pathogenic bacterial infections by exciting the intrinsic properties of herbal medicines as materials through a photo−sono interfacial engineering strategy.

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Section: Resultsmentioning

confidence: 92%

Photo-Sono Interfacial Engineering Exciting the Intrinsic Property of Herbal Nanomedicine for Rapid Broad-Spectrum Bacteria Killing

Liu

et al. 2021

ACS Nano

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“…PSS has been reported to have a good effect on reducing blood sugar and lipids in a rat model of diabetes induced by streptozotocin [19]. However, the diabetes model induced by streptozotocin is unstable and is affected by many factors, such as the instability of streptozotocin, the control of the injection dose and the number of injections, animal diet, and body weight [20]. Therefore, the international community now advocates the use of spontaneous db/db mouse model.…”

Section: Discussionmentioning

confidence: 99%

Effects of Marine Drug Propylene Glycol Alginate Sodium Sulfate on Glucose and Lipid Metabolism in Mice

Liang¹,

Li²,

Xiu³

2021

Mater. Plast.

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Previous studies have shown that marine drug propylene glycol alginate sodium sulfate (PSS) plays important roles in human diseases. This study mainly explored the effects of PSS on hyperglycemia and hyperlipidemia in diabetic db/db mouse models. The db/db mice were randomly divided into 5 groups (n=12), which were model control group (distilled water), positive control group (metformin), PSS low, medium, and high dose groups (PSS25, PSS50, PSS100) and normal control group (C57/BL, distilled water). The mice in each group had free diet and water for 90 days. During the experiment, food intake was recorded every day and body weight was recorded weekly. In addition, fasting blood glucose and glycosylated hemoglobin levels were measured regularly. Finally, the contents of triglyceride (TG), low-density lipoprotein (LDL-c), high-density lipoprotein (HDL-c) and total cholesterol (TC) in the serum of mice were determined. PSS can significantly reduce fasting blood glucose and glycosylated hemoglobin levels in db/db mice, and improve insulin sensitivity. Moreover, PSS can reduce the fat accumulation of db/db mice and significantly improve the blood lipid level of db/db mice. PSS can significantly improve the symptoms of glucose and lipid metabolism disorders in db/db mice.

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“…Boron decoration on a regular graphdiyne layer (BGDY) has also been considered as a possible electronic sensor for anticancer drugs like temozolomide (TMZ). The B decoration was also shown to increase the TMZ adsorption capabilities of GDY, related to an increase in its electrical conductivity of around 40%, according to ab initio calculations [ 92 ]. The 5-fluorouracil (5FU) anti-cancer drug—which shows no interaction with pristine GDY—can also be adsorbed by a BGDY composite, increasing the latter’s electrical conductivity by around 25%, a feature that would make BGDY suitable for 5FU sensing [ 93 ].…”

Section: Adsorption Of Molecules On Pristine or Nonmetal Functionalized Systemsmentioning

confidence: 99%

Carbon Nanostructures Doped with Transition Metals for Pollutant Gas Adsorption Systems

2021

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The adsorption of molecules usually increases capacity and/or strength with the doping of surfaces with transition metals; furthermore, carbon nanostructures, i.e., graphene, carbon nanotubes, fullerenes, graphdiyne, etc., have a large specific area for gas adsorption. This review focuses on the reports (experimental or theoretical) of systems using these structures decorated with transition metals for mainly pollutant molecules’ adsorption. Furthermore, we aim to present the expanding application of nanomaterials on environmental problems, mainly over the last 10 years. We found a wide range of pollutant molecules investigated for adsorption in carbon nanostructures, including greenhouse gases, anticancer drugs, and chemical warfare agents, among many more.

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Investigation the application of pristine graphdiyne (GDY) and boron-doped graphdiyne (BGDY) as an electronic sensor for detection of anticancer drug

Cited by 34 publications

References 33 publications

Photo-Sono Interfacial Engineering Exciting the Intrinsic Property of Herbal Nanomedicine for Rapid Broad-Spectrum Bacteria Killing

Photo-Sono Interfacial Engineering Exciting the Intrinsic Property of Herbal Nanomedicine for Rapid Broad-Spectrum Bacteria Killing

Effects of Marine Drug Propylene Glycol Alginate Sodium Sulfate on Glucose and Lipid Metabolism in Mice

Carbon Nanostructures Doped with Transition Metals for Pollutant Gas Adsorption Systems

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