Photo-Sono Interfacial Engineering Exciting the Intrinsic Property of Herbal Nanomedicine for Rapid Broad-Spectrum Bacteria Killing

Abstract

Large doses and long duration are often required for herbal medicines to kill bacteria effectively. Herein, a photoacoustic interfacial engineering strategy was utilized to endow curcumin (Cur, a kind of herbal medicine) with rapid and highly effective bacteria-killing efficacy, in which Cur was combined with CuS to form a hybrid material of CuS/Cur with tight contact through in situ nucleation and growth on the petaloid CuS surface. Due to the different work functions of CuS and Cur, the interfacial electrons were redistributed, i.e., a large number of electrons gathered on the side of CuS. In contrast, the holes gathered on the side of Cur after contact. An internal electric field was formed to drive the excited electrons to transfer from CuS to Cur, thus enhancing the separation of electron−hole pairs. Besides exerting the drug nature of Cur itself, the CuS/Cur hybrid also had photo−sono responsive ability, which endowed the hybrid with photothermal, photodynamic, and sonodynamic effects. Therefore, this Cur-based hybrid killed 99.56% of Staphylococcus aureus and 99.48% of Escherichia coli under 808 nm near-infrared light irradiation and ultrasound successively for 15 min, which was ascribed to the synergy of ROS, hyperthermia, and released Cu 2+ together with the drug properties of Cur. This work provides a strategy to enhance the therapeutic effects of herbal medicines against pathogenic bacterial infections by exciting the intrinsic properties of herbal medicines as materials through a photo−sono interfacial engineering strategy.

Rational Design of Multifunctional CuS Nanoparticle‐PEG Composite Soft Hydrogel‐Coated 3D Hard Polycaprolactone Scaffolds for Efficient Bone Regeneration

“…[42] Hence, this composite hydrogel scaffold could efficiently prevent bacterial infection during open surgical implantation. [43] Thus, a multifunctional D-CuS-PEG-PCL bone tissue engineering scaffold with sensitive photothermal properties, photoreactive controlled drug release behavior, and excellent antibacterial activity was manufactured.…”

Growth of Cu2O Nanoparticles on Two-Dimensional Zr–Ferrocene–Metal–Organic Framework Nanosheets for Photothermally Enhanced Chemodynamic Antibacterial Therapy

“…Bacterial infection is a severe threat to human health all over the world. , Because of the uncontrolled use of antibiotics for a long time, many bacteria have developed drug resistance, which will seriously threaten human health. , Therefore, there is a pressing need to design and develop new antimicrobial platforms to meet the needs of human beings. , In recent years, some antibacterial therapies without using antibiotics have been developed such as the controlled release of silver ions, , photothermal therapy (PTT), , chemodynamic therapy (CDT), − and photodynamic therapy (PDT). , Among them, CDT is a treatment that requires no extra energy input, and thus, it can avoid the limitation of light penetration in tissues . In the last decade, many inorganic nanomaterials, such as metal oxides ,, and metal chalcogenides, − have been developed as nanoagents for antibacterial through CDT because they can catalyze the Fenton or Fenton-like reaction with hydrogen peroxide to generate highly toxic hydroxyl radicals (·OH) to destroy biomolecules (such as DNA and proteins) in bacteria. Promisingly, metal–organic frameworks (MOFs) containing active metal cation centers (e.g., Fe 3+ , Co 3+ , etc.…”

ALD-induced TiO2/Ag nanofilm for rapid surface photodynamic ion sterilization

“…However, the bacterial membrane of the TiO 2 /Ag group exhibited obvious deformation and cracking, whether it was S. aureus or E. coli . It has been verified that ROS could react with membranes through multiple mechanisms, causing them to rupture, inducing protein leakage, and even entering bacteria to damage DNA and organelles [ 51 ]. In addition to the effect of ROS, the release of Ag + also played a certain role in the damage of the bacterial membrane.…”