Investigations into Antibacterial, Phytochemical and Antioxidant Properties of Vitellaria paradoxa (Gaertn.) Stem Bark Extracts

Olasunkanmi, Oluwaseun Oyetunji; Akinpelu, David A.; Adeniyi, Paul Opeyemi; Ajayi, Oludare Femi; Omololu-Aso, Joseph; Olorunmola, Felix Oluwasola

doi:10.9734/jpri/2017/38749

Cited by 6 publications

(14 citation statements)

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“…It was reported that shea itself exhibits extensive influence in treating a wide range of disorders such as fever, diarrhea, rash, skin disorders, wound infections, toothache, stomachache and others [31]. Moreover, shea butter shows different pharmacological activities such as anti-cancer [32], anti-inflammatory [33], anti-oxidant [34], anti-fungal, anti-viral [35] as well as anti-bacterial activity [36,37]. Focusing on its anti-bacterial behavior, shea is active against Gram-positive and Gram-negative bacterial strains, which is attributable to its phytochemical component, including steroids and flavonoids [37].…”

Section: Introductionmentioning

confidence: 99%

Shea Butter Potentiates the Anti-Bacterial Activity of Fusidic Acid Incorporated into Solid Lipid Nanoparticle

2022

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Fusidic acid (FA) is an efficient anti-bacterial drug proven to be efficient against a wide range of bacteria. Nevertheless, the main restriction in its formulation is the limited solubility. To avoid such an obstacle, the drug is incorporated into the lipid core of the nanolipid formulation. Consequently, the present study was an attempt to formulate nanolipid preparation, mainly, solid lipid nanoparticle (SLN) integrating FA. FA-SLN was prepared using shea butter as a lipid phase owing to its reported anti-bacterial activity. Different FA-SLNs were fabricated using the central composite design (CCD) approach. The optimized formula was selected and integrated into a hydrogel base to be efficiently used topically. FA-SLN-hydrogel was evaluated for its character, morphology, in vitro release and stability. The formula was examined for irritation reaction and finally evaluated for its anti-bacterial performance. The optimized formula showed particle size 283.83 nm and entrapment 73.057%. The formulated FA-SLN-hydrogel displayed pH 6.2, viscosity 15,610 cP, spreadability 51.1 mm and in vitro release 64.6% following 180 min. FA-SLN-hydrogel showed good stability for three months at different conditions (room temperature and refrigerator). It exhibited no irritation reaction on the treated rats. Eventually, shea butter displayed a noteworthy effect against bacterial growth that improved the effect of FA. This would indicate prospective anti-bacterial activity of FA when combined with shea butter in SLN formulation as a promising nanocarrier.

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Section: Introductionmentioning

confidence: 99%

Shea Butter Potentiates the Anti-Bacterial Activity of Fusidic Acid Incorporated into Solid Lipid Nanoparticle

2022

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“…Chen et al, (2019) suggested that SheaFlex75 may be an effective management strategy for symptom relief and cartilage protection in patients with both acute and chronic OA [16]. Olasunkanmi et al, (2017) and Kalgo et al, (2019) also reported that shea butter has antioxidant constituents with antibacterial and antifungal activities as well as immunomodulatory properties [17,18].…”

Section: Introductionmentioning

confidence: 99%

Explorative in vitro evaluation of the inhibitory effect of Vitellaria paradoxa seed oil extract on Staphylococcal conjunctivitis

Ekenze¹,

Utin²,

Ogundeko³

et al. 2022

Magna Sci. Adv. Biol. Pharm.

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More exploration on medicinal plants and other natural products in the present era of increase in poverty level and multi-drug resistance has become crucial. The aim of this study is to explore the inhibitory activities of Vitellaria paradoxa seed oil extract on isolated staphylococcal conjunctivitis. Cultured sample of Staphylococcus aureus isolated from a patient’s eye discharge in the Teaching Hospital Laboratory of the Imo State University, Nigeria having been diagnosed with bacterial conjunctivitis at the eye Clinic. After the incubation period, the diameter of zones of inhibition both horizontal and vertical were measured. Concentrations (100, 50 and 25mg/ml) of the ethanolic seed oil extract of V. paradoxa were assayed for the antibacterial activity - Minimum Inhibitory Concentration (MIC) using the agar well diffusion method. Ethanolic seed oil extract of V. paradoxa at concentration of 100mg /ml exhibited the highest zone of inhibition at 37.4mm for 24hrs followed by 50mg /ml and lowest using 25mg/ml (5.0mm) indicating a concentration-dependent inhibitory effect on Staphylococcal conjunctivitis. S. aureus isolated from conjunctivitis swab was susceptible to ethanolic seed oil extract of V. paradoxa at 100mg/ml, 50mg/ml and 25mg/ml concentrations, suggesting ethanolic extract of V. paradoxa oil as possessing antimicrobial property. Further exploration for its use as an ocular anti-bacterial agent is recommended.

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“…This may risk the life of individuals due to adverse toxicity (Oshikoya et al, 2008). People consume locally prepare PHF without prior knowledge of its safety and undesirable effect it may cause on their immune cells (Olasunkanmi et al, 2017). The Polyherbal formulation called "Garjin®" locally was claimed to have anti-HIV, anti-microbial and immunomodulatory activities by local herbalist.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory Activity of Aqueous Extract of Polyherbal Formulation on Macrophage Function and Humoral Immune Response against SRBCs in Mice

Hamid¹,

Shehu²,

Kalgo³

et al. 2021

NJPAS

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Several herbal formulation were not properly documented due to poor scientific data as well as poor standard regulation in preparation and marketing. The study evaluate the effect of aqueous extract of Polyherbal formulation on Macrophages’ phagocytic function and Humoral immune response in Mice A total of Sixteen 16 Mice was used. Group I received normal saline, Group II-IV received 500 mg, 1000 mg, and 1500 mg of Polyherbal formulation respectively for 21 days each. The animals were sensitized and challenged with Sheep red blood cells at day 14th and 19th of the treatment respectively. On day 21st all the animals were injected with 0.1 ml Indian ink for carbon clearance assay and blood sample was collected at 1 minute and 15 minutes of the injection. The phagocytic function of Macrophages and humoral immune response were determined spectrophotometrically and Hemagglutination assay respectively. The results show that the highest carbonic particle clearances index (K) median score (Median=0.0228), Macrophage phagocytose index (α) median score (Median=3.249), organ weight index (g/100g) mean score (M=0.06633) and Hemagglutination antibody titre median score (Median=32.00) was recorded by Group IV when compared with other groups. The carbonic particle clearance (K) (p=0.02), phagocytic index of Macrophage (α) (p=0.03), and organ weight index (g/100g) (p<0.0001) significantly increase with increase in the Polyherbal formulation concentration. Hemagglutination antibody titre against Sheep red blood cells (p=0.02) also significantly increased. The extract has potential immunostimulatory activity on both Macrophages’ phagocytic function and humoral immune response in mice thus could be useful in improving immune responses.

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Investigations into Antibacterial, Phytochemical and Antioxidant Properties of Vitellaria paradoxa (Gaertn.) Stem Bark Extracts

Cited by 6 publications

References 0 publications

Shea Butter Potentiates the Anti-Bacterial Activity of Fusidic Acid Incorporated into Solid Lipid Nanoparticle

Shea Butter Potentiates the Anti-Bacterial Activity of Fusidic Acid Incorporated into Solid Lipid Nanoparticle

Explorative in vitro evaluation of the inhibitory effect of Vitellaria paradoxa seed oil extract on Staphylococcal conjunctivitis

Immunomodulatory Activity of Aqueous Extract of Polyherbal Formulation on Macrophage Function and Humoral Immune Response against SRBCs in Mice

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