Investigations of kanuka and manuka essential oils for in vitro treatment of disease and cellular inflammation caused by infectious microorganisms

Chen, Chien-Chia; Yan, Sui-Hing; Yen, Muh–Yong; Wu, Pei-Fang; Liao, Wei‐Ting; Huang, Tsi-Shu; Wen, Zhi‐Hong; Wang, Hui‐Min David

doi:10.1016/j.jmii.2013.12.009

Cited by 47 publications

(52 citation statements)

References 33 publications

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“…A small number of publications report activity in vitro of other agents against Malassezia spp. These include plant‐derived substances such as Blad‐containing oligomer (an antifungal agent approved for agricultural use); beta‐thujaplicin, a honey‐based gel, kanuka and manuka and other plant‐derived essential oils; agents primarily used in the topical treatment of human dandruff or seborrhoeic dermatitis (selenium sulphide, zinc pyrithione, ciclopiroxolamine, rilopirox) and povidone–iodine . The calcineurin inhibitors (tacrolimus and pimecrolimus) have activity in vitro against human‐associated Malassezia yeasts .…”

Section: Antifungal Susceptibility Testing and Resistancementioning

confidence: 99%

Biology, diagnosis and treatment ofMalasseziadermatitis in dogs and cats Clinical Consensus Guidelines of the World Association for Veterinary Dermatology

Bond

Morris

Guillot

et al. 2020

Veterinary Dermatology

118

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Background -The genus Malassezia is comprised of a group of lipophilic yeasts that have evolved as skin commensals and opportunistic cutaneous pathogens of a variety of mammals and birds.Objectives -The objective of this document is to provide the veterinary community and other interested parties with current information on the ecology, pathophysiology, diagnosis, treatment and prevention of skin diseases associated with Malassezia yeasts in dogs and cats.Methods and material -The authors served as a Guideline Panel (GP) and reviewed the literature available prior to October 2018. The GP prepared a detailed literature review and made recommendations on selected topics. The World Association of Veterinary Dermatology (WAVD) Clinical Consensus Guideline committee provided guidance and oversight for this process. The document was presented at two international meetings of veterinary dermatology societies and one international mycology workshop; it was made available for comment on the WAVD website for a period of six months. Comments were shared with the GP electronically and responses incorporated into the final document.Conclusions and clinical importance -There has been a remarkable expansion of knowledge on Malassezia yeasts and their role in animal disease, particularly since the early 1990's. Malassezia dermatitis in dogs and cats has evolved from a disease of obscurity and controversy on its existence, to now being a routine diagnosis in general veterinary practice. Clinical signs are well recognised and diagnostic approaches are well developed. A range of topical and systemic therapies is known to be effective, especially when predisposing factors are identified and corrected.

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Section: Antifungal Susceptibility Testing and Resistancementioning

confidence: 99%

Biology, diagnosis and treatment ofMalasseziadermatitis in dogs and cats Clinical Consensus Guidelines of the World Association for Veterinary Dermatology

Bond

Morris

Guillot

et al. 2020

Veterinary Dermatology

118

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“…Aktivne komponente esencijalnog ulja manuke obuhvataju monoterpene, seskviterpene, leptospermon, metilcinamat, kariofilen, linalol i selinen, pri čemu njihova koncentracija u ulju zavisi od hemotipa biljke (14). Dosadašnja istraživanja esencijalnog ulja manuke pokazuju da ono ima značajnu antimikrobnu, antiinflamatornu, antivirusnu i miorelaksantnu aktivnost (15)(16)(17).…”

Section: Uvodunclassified

“…Dosadašnja istraživanja esencijalnog ulja vratića pokazuju njegovu značajnu antiinflamatornu, antihelmintsku, antivirusnu, antimikrobnu i antiulceroznu aktivnost (7,(19)(20)(21)(22) U daljem radu su korišćene 24-časovne kulture sojeva, a inokulum je pripreman u destilovanoj vodi denzitometrijskom metodom (Dinko Instrument Colorimetar, Barcelona), pri čemu je broj mikroorgani-zama standardizovan na 0,5 McFarland i podešavan na finalnu koncentraciju inokuluma od 103 do 104 CFU/mL Antifungalna aktivnost esencijalnih ulja matičnja-ka, manuke i vratića, dobijenih ljubaznošću doc. dr Ane Džamić sa Biološkog fakulteta Univerziteta u Beogradu, ispitivana je modifikovanom mikrodilucionim metodom (15,23). U tu svrhu su napravljene serije dvostrukih razblaženja za svako od esencijalnih ulja u rastvaraču, tj.…”

Section: Uvodunclassified

“…Dokazani su njegovi antimikrobni i antivirusni efekti na širok spektar patogena: Staphylococcus aureus, Escherichia coli, Candida albicans, Candida tropicalis, Malassezia furfur, Trichophyton spp., HSV-1 i HSV-2 (15,16). Pored toga, odlikuje se izuzetnim antiinflamatornim svojstvima (15), kao i značajnim miorelaksantnim efektom (17). Esencijalno ulje manuke ima širo-ku primenu na Novom Zelandu, u obliku komercijalnih Manex preparata (26).…”

Section: Diskusijaunclassified

“…Vrednosti MFC za Aspergillus u većini slučajeva nije bilo moguće odrediti jer su prevazilazile najveću ispitivanu koncentraciju (>50 μL/ mL). Slične rezultate su pokazali Čen (Chen) i saradnici, kao i Liz-Balkin (Lis-Balchin) i saradnici (15,32).…”

Section: Diskusijaunclassified

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Antifungal activity of essential oils of lemon balm, manuka and tansy to the causative agents of otomycosis

Jovanović¹,

Jovanovic²

2016

Medicinski podmladak

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SažetakUvod: Otomikoze su površne gljivične infekcije kože spoljašnjeg ušnog kanala. Jedan od terapijskih pristupa koji postaje aktuelan u lečenju otomikoza je primena esencijalnih ulja za koja je pokazano da imaju različita biološka svojstva, među kojima je i antimikrobni efekat.Cilj: Cilj istraživanja je ispitivanje antimikotičnog dejstva esencijalnih ulja matičnjaka (Melissa officinalis), manuke (Leptospermum scoparium) i vratića (Tanacetum vulgare) na uzročnike otomikoza.Materijal i metode: Ispitivana je osetljivost 20 sojeva Candida spp. i Aspergillus spp., izabranih metodom slučajnog izbora, izolovanih iz briseva spoljašnjeg ušnog kanala bolesnika sa znacima i simptomima otitis externe. Antigljivična aktivnost esencijalnih ulja matičnjaka, manuke i vratića ispitivana je mikrodilucionom metodom, određivanjem vrednosti minimalnih inhibitornih (MIC) i minimalnih fungicidnih koncentracija (MFC).Rezultati: Vrednosti MIC matičnjaka kretale su se u rasponu od 0,39 do 50 μL/mL, manuke od 0,39 do 50 μL/mL i vratića od 1,56 do 50 μL/mL. Minimalne fungicidne koncentracije su bile 2-4 puta veće od vrednosti MIC, izuzev u slučaju jednog soja Aspergillus niger koji je bio tolerantan na esencijalno ulje matičnjaka.Zaključak: Ispitivanjem aktivnosti esencijalnih ulja matičnjaka, manuke i vratića na sojeve Candida spp. i Aspergillus spp. mikrodilucionom metodom pokazano je da navedena esencijalna ulja imaju antimikotični efekat.Ključne reči: esencijalno ulje, Melissa officinalis, Leptospermum scoparium, Tanacetum vulgare, antimikotična aktivnost Abstrast Introduction: Otomycosis is а superficial fungal infection of the external ear canal. One of the therapeutic approaches that became topical in treatment of otomycosis is the application of essential oils, which is shown to have different biological properties, including the antimicrobial effect.Aim: The objective of the research is to examine antimycotic effects of essential oils of lemon balm (Melissa officinalis), manuka (Leptospermum scoparium) and tansy (Tanacetum vulgare) on the causative agents of otomycosis. Materials and Methods:In this study, we investigated the sensitivity of 20 randomly selected strains of Candida spp. and Aspergillus spp. isolated from swabs taken from the external ear canal of patients with signs and symptoms of otitis externa. Antifungal activity of essential oils of lemon balm, manuka and tansy was tested by using the microdilution method by determining the value of the Minimum inhibitory concentration (MIC) and Minimum fungicidal concentration (MFC).Results: MIC values of lemon balm were in the range of 0.39-50 μl/ml, manuka of 0.39-50 μL/mL and tansy of 1.56-50 μL/mL. The MFC values were 2-4 times higher than the MIC values, except in the case of a strain of Aspergillus niger, which was tolerant of the lemon balm essential oil. Conclusion:The investigation has shown that essential oil activities of lemon balm, manuka and tansy to the strains of Candida spp. and Aspergillus spp, using the microdilution method, have antifungal effect.

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Dimeric Acylphloroglucinol Derivatives with New Skeletons from Leptospermum scoparium

Xia

et al. 2021

Chemistry & Biodiversity

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Leptosparones A–F (1–6), six new dimeric acylphloroglucinol derivatives with unprecedented skeletons, were isolated from Leptospermum scoparium. Compounds 1–3 and 5–6 are phenylpropanoyl‐phloroglucinol dimers, while 4 is a phenylpropanoylphloroglucinol‐isovalerylphloroglucinol hybrid. Structurally, these compounds represent the first examples of dimeric phloroglucinols with unprecedented C(7′)−C(8) linkage between the phloroglucinol core and the acyl side chain. Their structures were elucidated by comprehensive analyses of spectroscopic data, single crystal X‐ray diffraction and chemical calculations. In addition, all compounds showed inhibitory effects against α‐glucosidase with IC50 values ranging from 39.5 to 186.8 μM.

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Investigations of kanuka and manuka essential oils for in vitro treatment of disease and cellular inflammation caused by infectious microorganisms

Cited by 47 publications

References 33 publications

Biology, diagnosis and treatment ofMalasseziadermatitis in dogs and cats Clinical Consensus Guidelines of the World Association for Veterinary Dermatology

Biology, diagnosis and treatment ofMalasseziadermatitis in dogs and cats Clinical Consensus Guidelines of the World Association for Veterinary Dermatology

Antifungal activity of essential oils of lemon balm, manuka and tansy to the causative agents of otomycosis

Dimeric Acylphloroglucinol Derivatives with New Skeletons from Leptospermum scoparium

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