Investigations on chitosan-carboxymethyl guar gum complexes interpolymer complexes for colon delivery of fluticasone.

Abstract

The present study was designed to formulate colon release tablets of fluticasone by employing cross linked chitosan (CH) and carboxymethyl guar gum (CMG) interpolymer complexes (IPC). Matrix tablets were prepared by wet granulation method using IPC as binder and coating agent. The IPC were characterized by Fourier transform infrared spectroscopy (FTIR). The uncoated and coated tablets were tested for their suitability as colon specific drug delivery system by in vitro dissolution studies. The coated tablets were evaluated for their pharmacodynamic performance after oral administration to TNBS induced ulcerative colitic rats. FTIR studies demonstrated that the IPC was formed through an electrostatic interaction between -COO − groups of CMG and -NH 3 + groups of CH. Tablets formulated with 50:50 CH:CMG as binder and coated with the respective ratio of IPC was capable of protecting the drug release in stomach and small intestine and delivering the drug in the colon. Histopathology of the rat colon after oral administration of these IPC film coated tablets revealed significantly greater (p<0.05) reduction in TNBS-induced ulcerative colitis The study confirmed that selective delivery of fluticasone to the colon can be achieved using cross-linked CH and CMG polysaccharides.

Optimization of pH conditions and characterization of polyelectrolyte complexes between gellan gum and cationic guar gum

“…The low swelling degree in pH 7.4 was attributed to the fact that prolonged immersion in water produced segmental mobility of interpolymeric chain in swollen state which allows the completion of interpolymeric reaction eventually leading to shrinkage. Similar swelling trends in pH 1.2 and 7.4 were also found in earlier studies when CH was complexed with carboxymethyl tamarind kernel powder, CS, and carboxymethyl guar gum …”

“…These opposite findings on exposure to pH 1.2 and 7.4 could be attributed to the different nature of ionic interactions at different pH. Similar FTIR results have been reported upon interactions of CH with carboxymethyl tamarind kernel powder, CS, and carboxymethyl guar gum before and after exposure to pH 1.2 and 7.4 …”

Microspheres of carboxymethyl guar gum for in vitro release of abacavir sulfate: Preparation and characterization

“…Soppimath and Aminabhavi 12 studied water transport and drug release characteristics of the crosslinked polyacrylamide‐grafted GG hydrogel microspheres. Kumar et al 20 reported the chitosan–carboxymethyl GG (CMGG)‐based interpolymer complexes for colon delivery of fluticasone. Bajpai and Sharma 21 investigated the pH‐sensitive swelling and vitamin B 12 release behavior of barium alginate/CMGG hydrogel beads.…”

Carboxymethylated Gums and Derivatization: Strategies and Significance in Drug Delivery and Tissue Engineering

“…Chitosan and carboxymethyl cashew gum compounds were developed, and their thermal stability was assessed by Maciel et al [ 94 ]. Carboxymethyl konjac glucomannan [ 95 ], carboxymethyl tamarind kernel powder [ 96 ], carboxymethyl fenugreek gum [ 97 ], carboxymethyl guar gum [ 98 ], carboxymethyl gum kondagogu [ 99 ], and cashew gum have been complexed with chitosan to form PECs and utilized in various drug delivery system.…”