Investigations on Serum Lipid Components and Serum Vitamin E in Iron Deficiency Anemia

Abstract

Investigations were carried out on serum lipid components and serum vitamin E in 54 cases of iron deficiency anemia during adolescence, with the following results: Serum levels of total lipids, free fatty acids, and phospholipids in cases of iron deficiency anemia were not different from those of the controls. Although the average value: of serum total cholesterol levels in the cases of iron deficiency anemia was not different from that of the controls, the percentage of subjects who showed low serum total cholesterol levels was greater in cases of iron deficiency anemia than in controls. The average values of serum triglyceride, serum beta-lipoprotein, or serum vitamin E were significantly lower than those of the controls, and the percentage of subjects who showed low serum levels of triglyceride, beta-lipoprotein, or vitamin E was greater in cases of iron deficiency anemia than in the controls. No significant correlation was noted between serum levels of vitamin E and total cholesterol. However, a moderate correlation was noted between serum levels of vitamin E and triglyceride, and a direct correlation was noted between serum levels of vitamin E and beta-lipoprotein.Vitamin E is a compound with antioxidant properties capable of protecting membrane lipids from oxidative degradation(1). A reduction in serum vitamin E concentration is associated with increased susceptibility of red blood cells to hemolysis on exposure to H2O2 in vitro(2-5). MELHORN and GROSS(6) reported that abnormally elevated H2O2 hemolysis values were observed in cases of severe iron deficiency anemia in children. As reported by the authors previously, abnormally elevated H2O2 hemolysis values and moderate reduction in serum vitamin E concentration were also observed in adult patients with iron deficiency anemia(7). The real cause of decreased serum vitamin E level in iron deficiency anemia is not known. However, as vitamin E is fat soluble, this paper investigates

A study of correlation between iron deficiency anaemia and serum lipid profile in Indian adults in BRIMS, Bidar

“…However, Ece et al 9 in a study on IDA children reported reduced LDL levels, which returned to control levels after the iron therapy. Serum TC did not show any significant alteration in the IDA group while previous studies have reported variable results in relation to TC, with some studies reporting it as normal, 10,20 while others reporting low levels. 8,9 Various studies have been performed to define the related mechanisms underlying dyslipidemias in IDA.…”

Serum lipids in suckling and post‐weanling iron‐deficient rats

“…Bloor and MacPherson (17) and Erickson et al (18) reported elevated lipids in anemic subjects. Others have found hypolipidemia in patients with anemias of various origins (19)(20)(21)(22) or no significant relationships between anemia and serum lipids (23). Since hyperlipidemia is recognized as a risk factor in the development of atherosclerotic heart disease, all nutritional influences on serum lipid concentrations assume considerable importance and warrant further study to enable us to more clearly understand the etiology of this disease.…”

Serum lipid levels in iron deficiency anemia and effects of various treatments.

“…On the contrary, lower cholesterol levels were reported in anemic humans by Elwood et al (1) and Rifkind and Gale (3). But Fujii and Shimizu (2) found no significant difference in total cholesterol levels between subjects with hemoglobin (Hb) levels less than 10.9g/100ml and greater than 12.0g/100ml. These studies suggest that there is a certain critical level of Hb for cholesterol decrement.…”

“…Effects of anemia on lipid levels in blood have been studied both in human (1)(2)(3)(4) and in animal (5)(6)(7)(8)(9)(10)(11)(12). The lipemia in iron-deficient and anemic animals is associated with elevated triglyceride levels while cholesterol levels may (9) or may not (7,11) be elevated.…”