Investigations on the effects of chronically administered small amounts of DDT in mice

Kemeny, T; Tar'ian, R

doi:10.1007/bf01901359

Cited by 28 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the FS generation the pretumorous lesions reached a maximum, but dropped in the F, generation. Tarjan and Kemeny also observed the highest incidence of leukosis in the Fa generation of mice treated with DDT (Kemeny and Tarjan, 1966;Tarjan and Kemeny, 1969). The fluctuations in the incidence of lung adenomas in several generations of mice painted with carcinogenic coal tar were observed long ago (Shabad 1928(Shabad , 1929.…”

Section: Discussionmentioning

confidence: 97%

“…The first experimental observation on the blastomogenic action of DDT in rats was made by Fitzhugh and Nelson in 1947. Since then reports on the carcinogenic effect of DDT in experiments have multiplied (Kemeny and Tarjan, 1966;Halver, 1967; Fitzhugh, 1969; Innes et al, 1969;Tarjan and Kemeny, 1969). The tumours that appeared in the treated animals were principally hepatomas, lung adenomas and lymphomas.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Transplacental and combined long‐term effect of DDT in five generations of a‐strain mice

Shabad¹,

Kolesnichenko²,

Nikonova³

1973

Intl Journal of Cancer

View full text Add to dashboard Cite

DDT must be evaluated as a weak carcinogen.One of the most widely used pesticides, DDT, continues to be a subject of increasing interest. The first experimental observation on the blastomogenic action of DDT in rats was made by Fitzhugh and Nelson in 1947. Since then reports on the carcinogenic effect of DDT in experiments have multiplied (Kemeny and Tarjan, 1966;Halver, 1967; Fitzhugh, 1969; Innes et al., 1969;Tarjan and Kemeny, 1969). The tumours that appeared in the treated animals were principally hepatomas, lung adenomas and lymphomas. However, in some experiments the blastomogenic effect of DDT was not substantiated (Durham, 1963 ; correspondence of Terracini and Tarjan, 1970;Agthe et al., 1970).In our laboratory it has been shown that diffuse and focal proliferation, adenomatous focal growth and, later, adenomas developed in lung organ cultures of foetal mice, rats and golden hamsters, the mothers of which had been treated with urethane, blastomogenic nitrosamines or hydrocarbons during the final period of pregnancy (Kolesnichenko, 1966(Kolesnichenko, , 1971(Kolesnichenko, , 1972 Smetanin, 1969;Shabad et al., 1971). The sameexperimental model was used to evaluate the possible carcinogenic effect of DDT.Organ cultures of foetal lung tissue from strain A mice exposed to DDT through the transplacental route showed intensive growth as compared to controls. A dose of 50 ppm of DDT induced epithelial preadenomatous lesions (diffuse hyperplasia and focal proliferation) in the first generation (F,) in 32.2 %. A progressively higher incidence of these lesions was observed at a dose level of 10ppm in F1 (8.9%), F, (16.4%) and F, (39.3 %) generations. However, the incidence dropped in the F4 (30.1%) and FS (20.1%) generations (Shabad et al., 1972). This paper deals with the results of a parallel study in vivo of the effect of DDT, especially on lung turnorigenesis in the same five generations of mice. In these multigeneration experiments we attempted to compare our results in organ culture in vitro and in mice in vivo, and evaluate the possible blastomogenic effect of the pesticide DDT.

show abstract

Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 99%

Transplacental and combined long‐term effect of DDT in five generations of a‐strain mice

Shabad¹,

Kolesnichenko²,

Nikonova³

1973

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…12 In the second study, successive generations of mice fed high doses of DDT showed increasing rates of leukemia and tumors. 13 The last study, a human study, found that DDT levels were twice as high in people who had died of cancer compared with those who had suffered sudden or accidental deaths. 14 The studies, the petitioners concluded, provided "clear evidence that DDT causes cancer in animals and provides very strong indications that it produces cancer in man."…”

Section: Fears Of Environmental Carcinogensmentioning

confidence: 99%

Debating the Health Effects of DDT: Thomas Jukes, Charles Wurster, and the Fate of an Environmental Pollutant

Conis

2010

Public Health Rep

View full text Add to dashboard Cite

The massive expansion of the chemical industry following World War II promised virtually unlimited improvements in everyday life. "Better Living Through Chemistry" was a marketing slogan that went virtually unchallenged throughout the 1950s and early 1960s. Yet, by the end of the 1960s, the perceptions of the synthetic world that our massive chemical industry had created had fundamentally changed. By the first Earth Day in the spring of 1970, the use of Dow's chemical defoliants and napalm, the experience with thalidomide, and, of course, the publication of Rachel Carson's Silent Spring profoundly undermined scientists' and the public's belief in the unchecked benefits of scores of chemicals. This brief but startling article by Conis provides us with insight into the rapidly evolving and transformative debates regarding the safety of synthetic materials, environmentalism, chronic disease, genetic damage, and low-level exposures during the 1960s and early 1970s. It also gives us an understanding of the current debates regarding the precautionary principle, low-level exposures and their relationships to human health, the concept of the threshold level, and the uncertainty involved in environmental research. As this article illustrates, perhaps the most critical and paradigmatic arguments occurred-and are still occurring-over the unbridled use of pesticides, particularly dichlorodiphenyltrichloroethane.

show abstract

“…Experiments designed to evaluate the immune system in the presence of Mirex have not been reported. On the other hand, fragmentary data are available on the immune system and tumor production for DDT and its analogues (Agthe et al, 1970;Fitzhugh and Nelson, 1947;Glick and Whatley, 1966;Kemeny and Tarjan, 1966;Tarjan and Kemeny, 1969;and Wasserman et al, 1969).…”

mentioning

confidence: 99%

Antibody-Mediated Immunity in the Presence of Mirex and DDT ,

Glick

1974

Poultry Science

View full text Add to dashboard Cite

show abstract

Investigations on the effects of chronically administered small amounts of DDT in mice

Cited by 28 publications

References 0 publications

Transplacental and combined long‐term effect of DDT in five generations of a‐strain mice

Transplacental and combined long‐term effect of DDT in five generations of a‐strain mice

Debating the Health Effects of DDT: Thomas Jukes, Charles Wurster, and the Fate of an Environmental Pollutant

Antibody-Mediated Immunity in the Presence of Mirex and DDT ,

Contact Info

Product

Resources

About