Investigations on the Interaction of Gold–Curcumin Nanoparticles with Human Peripheral Blood Lymphocytes

Sindhu, K.; Indra, Rasjad; Rajaram, A.; Sreeram, Kalarical Janardhanan; Rajaram, Rama

doi:10.1166/jbn.2011.1199

Cited by 26 publications

(16 citation statements)

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“…A recent study suggests that PLGA, CD, cellulose, nano-gel, and dendrimer based curcumin formulations did not show any erythrocytes damage or occurrence of thrombus [50]. Similar observations were made with intravenous PLGA nanosuspensions, curcumin conjugated nanoparticles [149–153], gold- curcumin nanoparticles, and a layer-by-layer self-assembly curcumin formulation [115, 135, 136, 154]. Rejinold et al [155] demonstrated the biocompatibility nature of a thermosensitive curcumin formulation by hemolysis assay.…”

Section: Curcumin Nanoformulationssupporting

confidence: 60%

Curcumin Nanomedicine: A Road to Cancer Therapeutics

Yallapu¹,

Jaggi²,

Chauhan³

2013

Current Pharmaceutical Design

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Cancer is the second leading cause of death in the United States. Conventional therapies cause widespread systemic toxicity and lead to serious side effects which prohibit their long term use. Additionally, in many circumstances tumor resistance and recurrence is commonly observed. Therefore, there is an urgent need to identify suitable anticancer therapies that are highly precise with minimal side effects. Curcumin is a natural polyphenol molecule derived from the Curcuma longa plant which exhibits anticancer, chemo-preventive, chemo- and radio-sensitization properties. Curcumin’s widespread availability, safety, low cost and multiple cancer fighting functions justify its development as a drug for cancer treatment. However, various basic and clinical studies elucidate curcumin’s limited efficacy due to its low solubility, high rate of metabolism, poor bioavailability and pharmacokinetics. A growing list of nanomedicine(s) using first line therapeutic drugs have been approved or are under consideration by the Food and Drug Administration (FDA) to improve human health. These nanotechnology strategies may help to overcome challenges and ease the translation of curcumin from bench to clinical application. Prominent research is reviewed which shows that advanced drug delivery of curcumin (curcumin nanoformulations or curcumin nanomedicine) is able to leverage therapeutic benefits by improving bioavailability and pharmacokinetics which in turn improves binding, internalization and targeting of tumor(s). Outcomes using these novel drug delivery systems have been discussed in detail. This review also describes the tumor-specific drug delivery system(s) that can be highly effective in destroying tumors. Such new approaches are expected to lead to clinical trials and to improve cancer therapeutics.

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Section: Curcumin Nanoformulationssupporting

confidence: 60%

Curcumin Nanomedicine: A Road to Cancer Therapeutics

Yallapu¹,

Jaggi²,

Chauhan³

2013

Current Pharmaceutical Design

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“…Encapsulation in polymeric nanoparticles, which are aggregates of cross-linked and random copolymers, has shown promise as an effective method of delivering curcumin. [20][21][22][23][24] Recently, the use of serum albumin as a carrier for curcumin has been reported, [25][26][27][28][29][30] implying that this protein has the ability to stabilize curcumin. Wang et al have shown that degradation of curcumin in buffer solution is suppressed in the presence of serum.…”

Section: Introductionmentioning

confidence: 99%

Curcumin Loaded Fibrinogen Nanoparticles for Cancer Drug Delivery

Rejinold¹,

Muthunarayanan²,

Chennazhi³

et al. 2011

j biomed nanotechnol

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In this work we prepared and evaluated the curcumin loaded fibrinogen nanoparticles (CRC-FNPs) as a novel drug delivery system for cancer therapy. These novel CRC-FNPs were prepared by a two-step co-acervation method using calcium chloride as the cross-linker. The prepared nanoparticles were characterized using dynamic light scattering (DLS), atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FT-IR), thermogravimetry (TG), differential thermal analysis (DTA) and X-ray diffraction (XRD) studies. DLS studies showed that the particle size of CRC-FNPs was in the range of 150-200 nm. The loading efficiency (LE) and in vitro drug release were studied using UV spectrophotometer. The LE was found to be 90%. The cytotoxicity was studied using L929 (mouse fibroblast), PC3 (prostate) and MCF7 (breast) cancer cell lines by MTT assay, which confirmed that CRC-FNPs were comparatively non toxic to L929 cell line while toxic to PC3 and MCF7 cancer cells. Cellular uptake of CRC-FNPs studied using L929, MCF-7 and PC3 cells monitored by fluorescent microscopy, demonstrated significant internalization and retention of nanoparticles inside the cells. The preferential accumulation of curcumin within the cancer cells were also confirmed by flowcytometry based uptake studies. The apoptosis assay showed increased apoptosis on MCF-7 compared to L929 cells. The blood compatibility of CRC-FNPs throws light on the fact that it is possible to administer the prepared nanoformulation intravenously. The results indicated that CRC-FNPs could be a promising therapeutic agent for cancer treatment.

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“…The average size of the particles was nearly 58 nm with a zeta potential of -23 mv. The particles were quite stable for nearly 6 mo at room temperature and no toxicity was reported in the in vitro studies so far [79] .…”

Section: Transdermal Drug Delivery System (Tdds)mentioning

confidence: 84%

Multifaceted Role of a Marvel Golden Molecule, Curcumin: a Review

Moselhy¹,

Razvi²,

Hasan³

et al. 2018

pharmaceutical-sciences

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Moselhy, et al.: Multifaceted Role of CurcuminCurcumin is chemically known as diferuloylmethane, which is an important nutraceutical obtained from the yellow spice Curcuma longa. It has been used traditionally as a folklore medicine in countries like India, China and Thailand for nearly 2000 years without any prior knowledge of the mechanism of action. Cellbased studies and clinical trials that have been reported so far have provided evidence that curcumin could be effectively used as antimicrobial, anticancer, antidiabetic, antiinflammatory, antimalarial and antioxidant. There are more than 9400 articles published on this "magical molecule" till date. Furthermore, nearly 100 clinical trials have been done using curcumin, which demonstrated safety, efficacy and prophylactic activity of curcumin. On the molecular level, curcumin has shown to modulate several crucial and significantly interlinked pathways in rendering an optimistic outcome against life-threatening diseases like cancer, diabetes, lupus nephritis, and other autoimmune and neurodegenerative diseases. In this communication, the chemical structure, biological properties and possible molecular targets of curcumin have been reviewed along with some recent developments in drug delivery systems of curcumin.

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Investigations on the Interaction of Gold–Curcumin Nanoparticles with Human Peripheral Blood Lymphocytes

Cited by 26 publications

References 0 publications

Curcumin Nanomedicine: A Road to Cancer Therapeutics

Curcumin Nanomedicine: A Road to Cancer Therapeutics

Curcumin Loaded Fibrinogen Nanoparticles for Cancer Drug Delivery

Multifaceted Role of a Marvel Golden Molecule, Curcumin: a Review

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