Drinking water was produced from Marmara seawater by membrane distillation (MD). The best operating conditions were determined by batch experiments as: 0.45 μm PTFE, 30°C distillate temperature and temperature difference, and 270-360 L/h cross-flow rates in feed-distillate. Seawater desalination was carried out with 99.93% solute rejection and 17.2 L/m 2 h permeate flux in 66% concentration ratio by lab-scale pilot system. Since the desalinated water contained no organic carbon, turbidity, and nitrate, it seemed to be very suitable for immediate service with quality of 7.3 pH, clear, odor-free, 76.0 μS/cm, 47.1 mg TDS/L, <0.001 color, and 0.01 mg boron/L. The product water lacked of vital cations, especially Nathat are essentials for promoting osmotic balanced body liquid and healthy development. A holistic management approach towards satisfying specific water quality requirements in direct service of MD effluents to human consumption was proposed that jointly included in injecting into urban potable water, adding appropriate chemicals into the effluent, and mixing effluents with raw or concentrated seawater (1:250/1:1000 for Marmara seawater) or brackish natural waters under hygienic precautions.