Invincible β‐cells in type 1 diabetes

Choe, Hun Jee; Cho, Young Min

doi:10.1111/jdi.13362

Cited by 1 publication

(1 citation statement)

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“…Fasting glucose levels are commonly used clinical indicators for monitoring the degree of glucose metabolism and blood glucose control, which is an essential part for the prevention and treatment of diabetes complications [16]. Peptide C levels indicate if the secretory function of β cells is working well or not in the body, and it can be used as a guiding indicator for the differentiation of diabetic patients and the identification of hypoglycemia [17]. Some present studies have shown that C-peptide has a good protective effect on diabetes and its complications.…”

Section: Discussionmentioning

confidence: 99%

An Untargeted Lipidomics Study of Acute Ischemic Stroke with Hyperglycemia Based on Ultrahigh-Performance Liquid Chromatography-Mass Spectrometry

Guo

Wang

Jiang

et al. 2022

Computational and Mathematical Methods in Medicine

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Patients with type 2 diabetes have twice as much of the risk of acute ischemic stroke (AIS) occurrence as healthy individuals, and the AIS patients with type 2 diabetes have a higher risk of death and a poorer prognosis. This study was to investigate the interrelationship between hyperglycemia and AIS and provided a reference for blood glucose management of AIS patients. The blood glucose level of AIS patients of the present study was controlled by insulin below 180 mg/dL (standard group) and between 80 and 130 mg/dL (management group). And the fasting venous blood samples were collected for determination of blood glucose level, homeostasis model assessment of insulin resistance (HOMA-IR), peptide C, and basal insulin level. Furthermore, lipids of the blood samples were detected using metabolomics, so as to clarify the similarities and differences in metabolic patterns in AIS patients with diabetes after the intervention of different glycemic strategies. The results revealed that compared to the standard group, the blood glucose level and HOMA-IR in the management group were significantly decreased, and levels of peptide C and basal insulin level were greatly increased. Through lipidomics detection, 83, 50, and 44 types of significantly upregulated differential lipids were detected in the standard vs. normal groups, the standard vs. management groups, and the management vs. normal groups, respectively, with triacylglycerol dominated. This study preliminarily revealed metabolic differences among AIS patients with hyperglycemia after different blood glucose intervention methods, hoping to provide a theoretical basis for clinical prevention and treatment of this disease.

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Section: Discussionmentioning

confidence: 99%