Invitation to participate in a multi-center study for validation of cerebral computed tomography angiography and computed tomography perfusion in the determination of cerebral circulatory arrest during brain death/death by neurological criteria diagnosis procedure in paediatric population below 12 years of age

Bohatyrewicz, Romuald; Sołek-Pastuszka, Joanna; Walas, Wojciech; Sznajder, Katarzyna; Falba, Andrzej; Chamier-Ciemińska, Katarzyna; Poncyljusz, Wojciech; Dąbrowski, Wojciech; Rybojad, Beata; Woźniak, Magdalena; Wojczal, Joanna; Luchowski, Piotr; Zielińska, Marzena; Guziński, Maciej; Sierakowska, Katarzyna; Kołakowska, T; Serafin, Zbigniew; Bartkowska-Śniatkowska, Alicja; Jończyk‐Potoczna, Katarzyna; Kobylarz, Krzysztof; Byrska-Maciejasz, Elżbieta; Wyrobek, Łukasz; Piotrowski, Andrzej; Jurkiewicz, Elżbieta; Kościesza, Andrzej; Migdał, Marek; Tałałaj, Mariola; Jakubów, Piotr; Janica, Jerzy; Pągowska‐Klimek, Izabela; Brzewski, Michał; Jurszewicz, Paweł; Dziejowska, Maria; Milewicz-Podgórska, Elżbieta; Bekiesińska‐Figatowska, Monika; Szurowska, Edyta; Owczuk, Radosław; Kusza, Krzysztof; Sawicki, Marcin

doi:10.5114/ait.2021.107189

Cited by 3 publications

(1 citation statement)

References 12 publications

(24 reference statements)

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“…149 Relatedly, Bohatyrewicz et al announced a multicenter study to validate use of CTA, CTP, and duplex Doppler insonation of the extracranial segments of the carotid and vertebral arteries as ancillary tests in patients <12 years old. 150…”

Section: Review Of the Wbdp And Updates Since Publicationmentioning

confidence: 99%

An Update on Brain Death/Death by Neurologic Criteria since the World Brain Death Project

Lewis

2024

Semin Neurol

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The World Brain Death Project (WBDP) is a 2020 international consensus statement that provides historical background and recommendations on brain death/death by neurologic criteria (BD/DNC) determination. It addresses 13 topics including: (1) worldwide variance in BD/DNC, (2) the science of BD/DNC, (3) the concept of BD/DNC, (4) minimum clinical criteria for BD/DNC determination, (5) beyond minimum clinical BD/DNC determination, (6) pediatric and neonatal BD/DNC determination, (7) BD/DNC determination in patients on ECMO, (8) BD/DNC determination after treatment with targeted temperature management, (9) BD/DNC documentation, (10) qualification for and education on BD/DNC determination, (11) somatic support after BD/DNC for organ donation and other special circumstances, (12) religion and BD/DNC: managing requests to forego a BD/DNC evaluation or continue somatic support after BD/DNC, and (13) BD/DNC and the law. This review summarizes the WBDP content on each of these topics and highlights relevant work published from 2020 to 2023, including both the 192 citing publications and other publications on BD/DNC. Finally, it reviews questions for future research related to BD/DNC and emphasizes the need for national efforts to ensure the minimum standards for BD/DNC determination described in the WBDP are included in national BD/DNC guidelines and due consideration is given to the recommendations about social and legal aspects of BD/DNC determination.

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Section: Review Of the Wbdp And Updates Since Publicationmentioning

confidence: 99%

An Update on Brain Death/Death by Neurologic Criteria since the World Brain Death Project

Lewis

2024

Semin Neurol

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Cerebral blood vessels and perfusion in the pediatric brain death: five cases studied by neuroimaging

Wang

et al. 2022

Neuroradiology

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Implementation of Computed Tomography Angiography (CTA) and Computed Tomography Perfusion (CTP) in Polish Guidelines for Determination of Cerebral Circulatory Arrest (CCA) during Brain Death/Death by Neurological Criteria (BD/DNC) Diagnosis Procedure

Bohatyrewicz

Pastuszka

Walas

et al. 2021

JCM

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Background: Brain death/death by neurologic criteria (BD/DNC) guidelines are routinely analyzed, compared and updated in the majority of countries and are later implemented as national criteria. At the same time, extensive works have been conducted in order to unify clinical procedures and to validate and implement new technologies into a panel of ancillary tests. Recently evaluated computed tomography angiography and computed tomography perfusion (CTA/CTP) seem to be superior to traditionally used digital subtraction angiography (DSA), transcranial Doppler (TCD) and cerebral perfusion scintigraphy for diagnosis of cerebral circulatory arrest (CCA). In this narrative review, we would like to demonstrate scientific evidence supporting the implementation of CTA/CTP in Polish guidelines for BD/DNC diagnosis. Research and implementation process: In the first of our base studies concerning the potential usefulness of CTA/CTP for the confirmation of CCA during BD/DNC diagnosis procedures, we showed a sensitivity of 96.3% of CTA in a group of 82 patients. CTA was validated against DSA in this report. In the second study, CTA showed a sensitivity of 86% and CTP showed a sensitivity of 100% in a group of 50 patients. In this study, CTA and CTP were validated against clinical diagnosis of BD/DNC supported by TCD. Additionally, we propose our CCA criteria for CTP test, which are based on ascertainment of cerebral blood flow (CBF) < 10 mL/100 g/min and cerebral blood volume < 1 mL/100 g in regions of interest (ROIs) localized in all brain regions. Based on our research results, CTA/CTP methods were implemented in Polish BD/DNC criteria. To our knowledge, CTP was implemented for the first time in national guidelines. Conclusions: CTA and CTP-derived CTA might be in future the tests of choice for CCA diagnosis, proper and/or Doppler pretest might significantly increase sensitivity of CTA in CCA diagnosis procedures. Whole brain CTP might be decisive in some cases of inconclusive CTA. Implementation of CTA/CTP in the Polish BD/DNC diagnosis guidelines does not show any major obstacles. We believe that in next edition of “The World Brain Death Project” CTA and CTP will be recommended as ancillary tests of choice for CCA confirmation during BD/DNC diagnosis procedures.

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Cited by 3 publications

References 12 publications

An Update on Brain Death/Death by Neurologic Criteria since the World Brain Death Project

An Update on Brain Death/Death by Neurologic Criteria since the World Brain Death Project

Cerebral blood vessels and perfusion in the pediatric brain death: five cases studied by neuroimaging

Implementation of Computed Tomography Angiography (CTA) and Computed Tomography Perfusion (CTP) in Polish Guidelines for Determination of Cerebral Circulatory Arrest (CCA) during Brain Death/Death by Neurological Criteria (BD/DNC) Diagnosis Procedure

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