Invited. MRI of laser‐induced interstitial thermal injury in an in vivo animal liver model with histologic correlation

Morrison, Paul R.; Jólesz, Ferenc A.; Charous, Daniel D; Mulkern, Robert V.; Hushek, Stephen G.; Margolis, Randall J.; Fried, Marvin P.

doi:10.1002/jmri.1880080114

Cited by 56 publications

(38 citation statements)

References 24 publications

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“…These results are consistent with previous studies that investigated the correlation of MRI and histology following focused ultrasound (7) and laser ablations (5). These studies suggest that the region within the inner border of the hyperintense rim in MR images corresponds to coagulation necrosis, and the region between the inner and outer border of the hyperintense rim will possibly become necrotic.…”

Section: Discussionsupporting

confidence: 92%

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Three‐dimensional method for comparing in vivo interventional MR images of thermally ablated tissue with tissue response

Breen

Lancaster

Lazebnik

et al. 2003

Magnetic Resonance Imaging

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Purpose:To investigate the ability of magnetic resonance (MR) to monitor radio-frequency (RF) ablation treatments by comparing MR images of thermal lesions to histologically assayed cellular damage. We developed a new methodology using three-dimensional registration for making spatial correlations. Materials and Methods:A low-field, open MRI system was used to guide an ablation probe into rabbit thigh muscle and acquire MR volumes after ablation. After fixation, we sliced and photographed the tissue at 3-mm intervals, using a specially designed apparatus, to obtain a volume of tissue images. Histologic samples were digitized using a video microscopy system. For our three-dimensional registration method, we used the tissue images as the reference, and registered histology and MR images to them using two different computer alignment steps. First, the MR volume was aligned to the volume of tissue images by registering needle fiducials placed near the tissue of interest. Second, we registered the histology images with the tissue images using a two-dimensional warping technique that aligned internal features and the outside boundary of histology and tissue images. Results:The MR and histology images were very well aligned, and registration accuracy, determined from displacement of needle fiducials, was 1.32 Ϯ 0.39 mm (mean Ϯ SD), which compared favorably to the MR voxel dimensions (0.70 mm in-plane and 3.0 mm thick). A preliminary comparison of MR and tissue response showed that the region inside the elliptical hyperintense rim in MR closely corresponds to the region of necrosis as established by histology, with a mean absolute distance between MR and histology boundaries of 1.17 mm, slightly smaller than the mean registration error. The MR region slightly overestimated the region of necrosis, with a mean signed distance between boundaries of 0.85 mm. Conclusion:Our results suggest that our methodology can be used to achieve three-dimensional registration of histology and in vivo MR images. In MR lesion images, the inner border of the hyperintense region corresponds to the border of irreversible cell damage. This is good evidence that during RF ablation treatments, iMRI lesion images can be used for real-time feedback.

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Section: Discussionsupporting

confidence: 92%

“…Previous studies indicate that regions of low MR signal in images obtained minutes after thermal ablation correlate with regions of tissue damage (1)(2)(3)(4)(5)(6)(7). Analysis was typically done using geometric measurements without alignment of histology to MR images (3,4,6).…”

mentioning

confidence: 99%

Three‐dimensional method for comparing in vivo interventional MR images of thermally ablated tissue with tissue response

Breen

Lancaster

Lazebnik

et al. 2003

Magnetic Resonance Imaging

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“…Less energy is delivered to the margins because of higher risk of organ perforation or damage to neighboring tissues . LITT debulking procedures causes boiling of tissue water and subsequent irreversible thermal damage, which will ultimately lead to photoevaporation at the tumor core (100 o C) (Chapman, 1998;Hallddorsson and Langerholc, 1978;Marchesini et al, 1985;Morrison et al, 1998). Local recurrence after LITT is related to residual disease due to reversible cellular thermal damage on the margins treated with subtherapeutic energy levels (40-60 o C) in head and neck and prostate tumor ablation (Anzai et al, 1991;Marchesini et al, 1985).…”

Section: Intratumor Injections Of Chemotherapy and Laser For Effectivmentioning

confidence: 99%

Laser Photo Chemotherapy: An Alternative Treatment for Cancer

Paiva¹,

Palumbo²,

Greggio³

et al. 2011

Current Cancer Treatment - Novel Beyond Conventional Approaches

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“…However, in the context of evaluating treatment changes for neurological conditions, such as glioblastoma multiforme (GBM), 4,5 patients are monitored qualitatively in a clinical setting via volumetric analysis on gadolinium-contrast T1-w (Gd-T1) MRI protocol. 6 Gd-T1 allows for capture of volume of enhancement within ablation focus post-treatment, acquired at regular time intervals (24 h, 1 month, 3 months, and 6 months post-treatment) and comparing these changes with reference to pretreatment Gd-T1 to identify patients who may still be prone to treatment failure.…”

Section: Introductionmentioning

confidence: 99%

Association of computerized texture features on MRI with early treatment response following laser ablation for neuropathic cancer pain: preliminary findings

et al. 2015

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Abstract. Laser interstitial thermal therapy (LITT) has recently emerged as a new treatment modality for cancer pain management that targets the cingulum (pain center in the brain) and has shown promise over radio frequency (RF)-based ablation, due to magnetic resonance image (MRI) guidance that allows for precise ablation. Since laser ablation for pain management is currently exploratory and is only performed at a few centers worldwide, its short-and long-term effects on the cingulum are currently unknown. Traditionally, treatment effects for neurological conditions are evaluated by monitoring changes in intensities and/or volume of the ablation zone on post-treatment Gadolinium-contrast T1-w (Gd-T1) MRI. However, LITT introduces subtle localized changes corresponding to tissues response to treatment, which may not be appreciable on visual inspection of volumetric or intensity changes. Additionally, different MRI protocols [Gd-T1, T2w, gradient echo sequence (GRE), fluidattenuated inversion recovery (FLAIR)] are known to capture complementary diagnostic information regarding the patient's response to treatment; the utility of these MRI protocols has so far not been investigated to evaluate early and localized response to LITT treatment in the context of neuropathic cancer pain. In this work, we present the first attempt at (a) examining early treatment-related changes on a per-voxel basis via quantitative comparison of computer-extracted texture descriptors across pre-and post-LITT multiparametric (MP-MRI) (Gd-T1, T2w, GRE, FLAIR), subtle microarchitectural texture changes that may not be appreciable on original MR intensities or volumetric differences, and (b) investigating the efficacy of different MRI protocols in accurately capturing immediate post-treatment changes reflected (1) within and (2) outside the ablation zone. A retrospective cohort of four patient studies comprising pre-and immediate (24 h) post-LITT 3 Tesla Gd-T1, T2w, GRE, and FLAIR acquisitions was considered. Our quantitative approach first involved intensity standardization to allow for grayscale MR intensities acquired pre-and post-LITT to have a fixed tissue-specific meaning within the same imaging protocol, the same body region, and within the same patient. An affine registration was then performed on individual post-LITT MRI protocols to a reference MRI protocol pre-LITT. A total of 78 computerized texture features (co-occurrence matrix homogeneity, neighboring gray-level dependence matrix, Gabor) are then extracted from pre-and post-LITT MP-MRI on a per-voxel basis. Quantitative, voxelwise comparison of the changes in MRI texture features between pre-and post-LITT MRI indicate that (a) Gabor texture features at specific orientations were highly sensitive as well as specific in predicting subtle microarchitectural changes within and around the ablation zone pre-and post-LITT, (b) FLAIR was identified as the most sensitive MRI protocol in identifying early treatment changes yielding a normalized percentage change of 360% within the ablat...

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Invited. MRI of laser‐induced interstitial thermal injury in an in vivo animal liver model with histologic correlation

Cited by 56 publications

References 24 publications

Three‐dimensional method for comparing in vivo interventional MR images of thermally ablated tissue with tissue response

Three‐dimensional method for comparing in vivo interventional MR images of thermally ablated tissue with tissue response

Laser Photo Chemotherapy: An Alternative Treatment for Cancer

Association of computerized texture features on MRI with early treatment response following laser ablation for neuropathic cancer pain: preliminary findings

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