2011
DOI: 10.1002/bip.21624
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Invited review: Probing the structures of muscle regulatory proteins using small‐angle solution scattering

Abstract: Small‐angle X‐ray and neutron scattering with contrast variation have made important contributions in advancing our understanding of muscle regulatory protein structures in the context of the dynamic molecular processes governing muscle action. The contributions of the scattering investigations have depended upon the results of key crystallographic, NMR, and electron microscopy experiments that have provided detailed structural information that has aided in the interpretation of the scattering data. This revie… Show more

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Cited by 6 publications
(8 citation statements)
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References 86 publications
(103 reference statements)
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“…Kratky plots of Ca 2ϩ /CaM and Ca 2ϩ / CaM-Cpep complex are consistent with largely folded globular proteins with some flexibility (data not shown). It appears that this flexibility is retained to a similar degree in the Ca 2ϩ /CaM-Cpep complex as in Ca 2ϩ /CaM alone, consistent with the NMR titration experiments with 15 N-labeled Ca 2ϩ /CaM-Cpep showing that residues within the central helix do not experience large chemical shift changes when the two lobes bind to Cpep.…”
Section: The C-terminal End Of the Motif Alone Is Sufficient For Bindsupporting
confidence: 68%
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“…Kratky plots of Ca 2ϩ /CaM and Ca 2ϩ / CaM-Cpep complex are consistent with largely folded globular proteins with some flexibility (data not shown). It appears that this flexibility is retained to a similar degree in the Ca 2ϩ /CaM-Cpep complex as in Ca 2ϩ /CaM alone, consistent with the NMR titration experiments with 15 N-labeled Ca 2ϩ /CaM-Cpep showing that residues within the central helix do not experience large chemical shift changes when the two lobes bind to Cpep.…”
Section: The C-terminal End Of the Motif Alone Is Sufficient For Bindsupporting
confidence: 68%
“…Upon the addition of C1C2 to 15 N-labeled Ca 2ϩ /CaM, many peaks in the 15 N HSQC spectrum experienced a severe drop in signal intensity and disappeared (Fig. 7A) ) when bound to C1C2 again mapped specifically to the hydrophobic clefts in each of the two lobes of CaM, similar to the result for Cpep (Fig.…”
Section: The C-terminal End Of the Motif Alone Is Sufficient For Bindsupporting
confidence: 66%
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