Involution of Bursa of Fabricius in Male and Female Chickens: A Light Microscopic Histoquantitative Study

Milićević, Živana; Vujić, Drinka; Isaković, Katarina; Mićić, Mileva; Milićević, Novica M.

doi:10.3382/ps.0652318

Cited by 8 publications

(4 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The regression of the bursa of Fabricius in chukar partridge (Alectoris chukar) and ring-necked pheasant (Phasianus colchicus) is accomplished by a decrease in the bursal weight, which is more prominent in the male than in the female, and the same was observed in the domestic selection of Prelux Bro chickens (Milicevic et al, 1986). Nevertheless, and in contrast with the above data, Mercer-Oltjen and Woodard (1987) observed that in the ring-necked pheasants (Phasianus colchicus), the decline was parallel in both sexes.…”

Section: Bursa Of Fabriciusmentioning

confidence: 68%

Age‐related changes in the avian primary lymphoid organs (thymus and bursa of Fabricius)

Ciriaco

Piñera

Díaz-Esnal

et al. 2003

Microscopy Res & Technique

View full text Add to dashboard Cite

The avian primary lymphoid organs, the thymus and the bursa of Fabricius, undergo age-dependent changes leading in some cases to the complete atrophy of the organ. Nevertheless, the timetable of the involutive process as well as the consequences in the structure and functionality of the organs vary largely in the time frame and structural changes among species. On the other hand, and in contrast with the large body of literature reporting the structural and functional changes in mammalian primary lymphoid organs, the age-dependent changes in avian thymus and bursa of Fabricius are scarce, fragmentary, and heterogeneous. This article reviews the current literature on this topic, and focuses primarily on the involution of the bursa of Fabricius.

show abstract

Section: Bursa Of Fabriciusmentioning

confidence: 68%

Age‐related changes in the avian primary lymphoid organs (thymus and bursa of Fabricius)

Ciriaco

Piñera

Díaz-Esnal

et al. 2003

Microscopy Res & Technique

View full text Add to dashboard Cite

show abstract

“…These top enriched transcription factors in the H3K27ac DERs between non-treated Fayoumi and Leghorn suggest potential differences in binding activity between the lines, which implicate that B-cell development may vary between the lines. This is unsurprising given that bursal development can differ between lines (MiliĆEviĆ et al, 1986). Further studies collecting phenotypic data such as immune cell profiles and populations using flow cytometry across lymphoid tissues of the two lines are warranted to confirm this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Integrated Transcriptome and Histone Modification Analysis Reveals NDV Infection Under Heat Stress Affects Bursa Development and Proliferation in Susceptible Chicken Line

et al. 2020

View full text Add to dashboard Cite

Two environmental factors, Newcastle disease and heat stress, are concurrently negatively impacting poultry worldwide and warrant greater attention into developing genetic resistance within chickens. Using two genetically distinct and highly inbred layer lines, Fayoumi and Leghorn, we explored how different genetic backgrounds affect the bursal response to a treatment of simultaneous Newcastle disease virus (NDV) infection at 6 days postinfection (dpi) while under chronic heat stress. The bursa is a primary lymphoid organ within birds and is crucial for the development of B cells. We performed RNA-seq and ChIP-seq targeting histone modifications on bursa tissue. Differential gene expression revealed that Leghorn, compared to Fayoumi, had significant down-regulation in genes involved in cell proliferation, cell cycle, and cell division. Interestingly, we also found greater differences in histone modification levels in response to treatment in Leghorns than Fayoumis, and biological processes enriched in associated target genes of H3K27ac and H3K4me1 were similarly associated with cell cycle and receptor signaling of lymphocytes. Lastly, we found candidate variants between the two genetic lines within exons of differentially expressed genes and regulatory elements with differential histone modification enrichment between the lines, which provides a strong foundation for understanding the effects of genetic variation on NDV resistance under heat stress. This study provides further understanding of the cellular mechanisms affected by NDV infection under heat stress in chicken bursa and identified potential genes and regulatory regions that may be targets for developing genetic resistance within chickens.

show abstract

“…At the age of 5 months in chickens and 4 months in pigeons, bursal atrophy can be noticed (Naukkarinen & Sorvari, 1984;Bickford et al, 1985;Sanchez-Refusta et al, 1996). Bursal involution is faster in male chickens than in hens (Milićević et al, 1986). When involution is complete, at the age of 6 months, only a fibrotic residue without intact lymphoid structures remains (Naukkarinen & Sorvari, 1984;Bickford et al, 1985).…”

Section: Introductionmentioning

confidence: 87%

Locations of gut-associated lymphoid tissue in the 3-month-old chicken: a review

et al. 2010

View full text Add to dashboard Cite

Involution of Bursa of Fabricius in Male and Female Chickens: A Light Microscopic Histoquantitative Study

Cited by 8 publications

References 16 publications

Age‐related changes in the avian primary lymphoid organs (thymus and bursa of Fabricius)

Age‐related changes in the avian primary lymphoid organs (thymus and bursa of Fabricius)

Integrated Transcriptome and Histone Modification Analysis Reveals NDV Infection Under Heat Stress Affects Bursa Development and Proliferation in Susceptible Chicken Line

Locations of gut-associated lymphoid tissue in the 3-month-old chicken: a review

Contact Info

Product

Resources

About