Involvement and Roles of Long Noncoding RNAs in the Molecular Mechanisms of Emerging and Reemerging Viral Infections

This review discusses the possible involvement of infections-associated cancers in humans, with virus infections contributing 15% to 20% of total cancer cases in humans. DNA virus encoded proteins interact with host cellular signaling pathways and control proliferation, cell death and genomic integrity viral oncoproteins are known to bind cellular Deubiquitinates (DUBs) such as cyclindromatosis tumor suppressor, ubiquitin-specific proteases 7, 11, 15 and 20, and A-20 to improve their intracellular stability and cellular signaling pathways and finally transformation. Human papillomaviruses (cervical carcinoma, oral cancer and laryngeal cancer); human polyomaviruses (mesotheliomas, brain tumors); Epstein-Barr virus (B-cell lymphoproliferative diseases and nasopharyngeal carcinoma); Kaposi’s Sarcoma Herpesvirus (Kaposi’s Sarcoma and primary effusion lymphomas); hepatitis B (hepatocellular carcinoma (HCC)) cause up to 20% of malignancies around the world.

show abstract

“…Tumor suppressor genes participate in cell growth and mutation in one allele causes great risk for malignancy development ( Figure 1 ). 18 - 20 …”

Section: Human Oncogenic Dna Virusesmentioning

confidence: 99%

“…Tumor suppressor genes participate in cell growth and mutation in one allele causes great risk for malignancy development (Figure 1). [18][19][20] Oncogenesis Oncogenic viruses comprise of both DNA and RNA viruses. Virus oncogenes are responsible for encoding the viral proteins that are necessary for the virus to replicate.…”

Section: Introductionmentioning

confidence: 99%