Involvement of 5-hydroxytryptamine1A receptors in the descending anti-nociceptive pathway from periaqueductal gray to the spinal dorsal horn in intact rats, rats with nerve injury and rats with inflammation

Liu, Zhi‐Yang; Zhuang, Dingding; Lunderberg, T.; Yu, Long-Chuan

doi:10.1016/s0306-4522(02)00038-6

Cited by 54 publications

(33 citation statements)

References 46 publications

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“…This putative sensory modulation role is consistent with the presence of 5-HT receptors in the dorsal horn of the lumbosacral spinal cord (Liu et al, 2002). Furthermore, numerous findings associate 5-HT with sensory input modulation (Machacek et al, 2001;Meuser et al, 2002;Miquel et al, 2002;Shay and Hochman, 2002;Bosco et al, 2003;Hains et al, 2003).…”

Section: Discussionsupporting

confidence: 80%

Spinal Cord-Transected Mice Learn to Step in Response to Quipazine Treatment and Robotic Training

Fong¹,

Cai²,

Otoshi³

et al. 2005

J. Neurosci.

131

126

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In the present study, concurrent treatment with robotic step training and a serotonin agonist, quipazine, generated significant recovery of locomotor function in complete spinal cord-transected mice (T7-T9) that otherwise could not step. The extent of recovery achieved when these treatments were combined exceeded that obtained when either treatment was applied independently. We quantitatively analyzed the stepping characteristics of spinal mice after alternatively administering no training, manual training, robotic training, quipazine treatment, or a combination of robotic training with quipazine treatment, to examine the mechanisms by which training and quipazine treatment promote functional recovery. Using fast Fourier transform and principal components analysis, significant improvements in the step rhythm, step shape consistency, and number of weight-bearing steps were observed in robotically trained compared with manually trained or nontrained mice. In contrast, manual training had no effect on stepping performance, yielding no improvement compared with nontrained mice. Daily bolus quipazine treatment acutely improved the step shape consistency and number of steps executed by both robotically trained and nontrained mice, but these improvements did not persist after quipazine was withdrawn. At the dosage used (0.5 mg/kg body weight), quipazine appeared to facilitate, rather than directly generate, stepping, by enabling the spinal cord neural circuitry to process specific patterns of sensory information associated with weight-bearing stepping. Via this mechanism, quipazine treatment enhanced kinematically appropriate robotic training. When administered intermittently during an extended period of robotic training, quipazine revealed training-induced stepping improvements that were masked in the absence of the pharmacological treatment.

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Section: Discussionsupporting

confidence: 80%

Spinal Cord-Transected Mice Learn to Step in Response to Quipazine Treatment and Robotic Training

Fong¹,

Cai²,

Otoshi³

et al. 2005

J. Neurosci.

131

126

View full text Add to dashboard Cite

show abstract

“…(Liu et al, 2002), i.p. (Agren et al, 1997), and intracisternal administration of OT (Arletti et al, 1993), as well as direct injections of OT to the PAG and the nucleus raphe magnus (Robinson et al, 2002), induced antinociceptive effects in animals and humans (Arletti et al, 1993;Lundeberg et al, 1994;Louvel et al, 1996;Petersson et al, 1996;Agren et al, 1997;Caron et al, 1998;Kang and Park, 2000).…”

Section: Modulation Of Serotonin Transmissionmentioning

confidence: 99%

The Endomorphin System and Its Evolving Neurophysiological Role

Fichna

Janecka²,

Costentin³

et al. 2007

Pharmacol Rev

222

171

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“…5-Hydroxytryptamine is released primarily from descending bulbospinal serotonergic neurons and causes analgesia (Sorkin et al 1993;Liu et al 2002). In the periphery, 5-HT is released from platelets, mast cells and endothelial cells into a wound site in response to inflammation and injury (Lehtosalo et al 1984).…”

mentioning

confidence: 99%

Potentiation of transient receptor potential V1 functions by the activation of metabotropic 5‐HT receptors in rat primary sensory neurons

Ohta

Ikemi

Murakami

et al. 2006

The Journal of Physiology

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show abstract

Involvement of 5-hydroxytryptamine1A receptors in the descending anti-nociceptive pathway from periaqueductal gray to the spinal dorsal horn in intact rats, rats with nerve injury and rats with inflammation

Cited by 54 publications

References 46 publications

Spinal Cord-Transected Mice Learn to Step in Response to Quipazine Treatment and Robotic Training

Spinal Cord-Transected Mice Learn to Step in Response to Quipazine Treatment and Robotic Training

The Endomorphin System and Its Evolving Neurophysiological Role

Potentiation of transient receptor potential V1 functions by the activation of metabotropic 5‐HT receptors in rat primary sensory neurons

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