2019
DOI: 10.1002/jcp.28622
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Involvement of aberrant regulation of epigenetic mechanisms in the pathogenesis of Parkinson's disease and epigenetic‐based therapies

Abstract: Parkinson's disease (PD) is known as a progressive neurodegenerative disorder associated with the reduction of dopamine-secreting neurons and the formation of Lewy bodies in the substantia nigra and basal ganglia routes. Aging, as well as environmental and genetic factors, are considered as disease risk factors that can make PD as a complex one. Epigenetics means studying heritable changes in gene expression or function, without altering the underlying DNA sequence. Multiple studies have shown the association … Show more

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Cited by 34 publications
(33 citation statements)
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References 156 publications
(215 reference statements)
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“…EV-cargo was assessed for deiminated proteins as well as for three key microRNAs known to contribute to inflammation and hypoxia (miR21, miR155, and miR210), all of which have also been associated to neurodegenerative diseases and PD [23][24][25], but have not been related to, or assessed in, pre-motor PD before the current study. Epigenetic mechanisms of PD have indeed received increasing attention, including histone modifications, DNA methylation, as well as microRNA involvement [26,27]. Our findings identify EVs and protein deimination as novel markers in pre-motor stages of PD.…”
Section: Introductionmentioning
confidence: 64%
See 1 more Smart Citation
“…EV-cargo was assessed for deiminated proteins as well as for three key microRNAs known to contribute to inflammation and hypoxia (miR21, miR155, and miR210), all of which have also been associated to neurodegenerative diseases and PD [23][24][25], but have not been related to, or assessed in, pre-motor PD before the current study. Epigenetic mechanisms of PD have indeed received increasing attention, including histone modifications, DNA methylation, as well as microRNA involvement [26,27]. Our findings identify EVs and protein deimination as novel markers in pre-motor stages of PD.…”
Section: Introductionmentioning
confidence: 64%
“…Recent work has emphasised the association of selected microRNAs to PD [27,122,123] and roles for microRNAs in neuroinflammation have received increased attention [25,124]. As neuroinflammation is thought to be a facilitator of PD pathogenesis, and was observed in the pre-motor PD model used in this study [32,125], we assessed changes in relative expression levels of three inflammatory and hypoxia associated microRNAs: miR21, miR155, and miR210.…”
Section: Discussionmentioning
confidence: 99%
“…Whether epigenetic mechanisms in embryonic DA neurogenesis also impact on progression in Parkinson's disease remains to be determined. Recently, there has been strong interest in epigenetic mechanisms in mammalian midbrain DA development, stem cell derived new dopaminergic neurons, as well as in potentially neuroprotective pathways that may slow down disease progression (van Heesbeen et al, 2013;Renani et al, 2019;van Heesbeen and Smidt, 2019). In animal models of Parkinson's disease, HAT inhibitors in co-treatment with L-DOPA have been suggested to have therapeutic potential (Ryu et al, 2018).…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, alterations in epigenetic modulation seem to play an important role in the etiopathology of PD. The brains of these patients present changes in DNA methylation, post-translational modifications of histones and of microRNAs that regulate pathways involved in the pathophysiology of PD (Armstrong et al, 2019;Prasad and Jho, 2019;Renani et al, 2019).…”
Section: Dna Damage and Repairmentioning
confidence: 99%