Involvement of aquaporins in colorectal carcinogenesis

Moon, Chulso; Soria, Jean Charles; Jang, Se Jin; Lee, Juna; Hoque, Mohammad Obaidul; Sibony, Mathilde; Trink, Barry; Chang, Yoon Soo; Sidransky, David; Li, Mao

doi:10.1038/sj.onc.1206762

Cited by 180 publications

(169 citation statements)

References 23 publications

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“…Expression of hAQP1 is frequently associated with brain tumors, colon cancers, and microvessels of multiple myeloma (MM) paralleling angiogenesis [6][7][8]. Other reports have alluded to the role of other AQPs in the development of human cancer [6,8,9].…”

Section: Introductionmentioning

confidence: 99%

“…For example, expression of AQP3 was increased in renal cell cancer, as was AQP5 in pancreatic cancer [9,10]. AQP1 appears to be involved in cell cycle control [8,11], and expression of hAQP1, hAQP3, and hAQP5 have been shown to be simultaneously induced during lymphocyte activation [12]. Most recently, based on the novel oncogenic properties of AQP1, increased levels of AQP1 were suggested to play a role in tumorigenesis [13].…”

Section: Introductionmentioning

confidence: 99%

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Overexpression of AQP5, a putative oncogene, promotes cell growth and transformation

et al. 2008

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Overexpression of several aquaporins has been reported in different types of human cancer but the role of AQPs in human carcinogenesis has not yet been clearly defined. Here, we demonstrate that ectopic expression of human AQP5 (hAQP5), a water channel expressed in lung, salivary glands, and kidney, induces many phenotypic changes characteristic of transformation both in vitro and in vivo. Furthermore, the cell proliferative ability of AQP5 appears to be dependent upon the phosphorylation of a cAMP-protein kinase (PKA) consensus site located in a cytoplasmic loop of AQP5. In addition, phosphorylation of the PKA consensus site was found to be phosphorylated preferentially in tumors. These findings altogether indicate that hAQP5 plays an important role in human carcinogenesis and, furthermore, provide an attractive therapeutic target.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Overexpression of AQP5, a putative oncogene, promotes cell growth and transformation

et al. 2008

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“…Reviewing the literature, we find that this association has been suggested mainly in relation to a role for these proteins in cell volume changes, 3,5,8 or in the case of a subgroup of AQPs, called aquaglyceroporins, 11,12 to their permeability to solutes such as glycerol and hydrogen peroxide. [13][14][15][16][17][18] Additionally, various studies have demonstrated that AQP expression is modified over the course of the cell cycle [19][20][21][22][23] and, more recently, we have shown that overexpression of AQP1 and AQP3 alters the levels of essential checkpoint proteins (cyclins) relevant for cell cycle progression, in addition to modifying the levels of transcription factors, and cytokines.…”

Section: Introductionmentioning

confidence: 83%

“…[2][3][4][5] Since the beginning, the idea behind a role for AQPs in tumor process was basically associated with their contribution to changes in cell volume necessary for cells to proliferate and differentiate. Initial studies demonstrated high AQP1 expression in proliferating microvessels of many tumors.…”

Section: Introductionmentioning

confidence: 99%

Role of aquaporins in cell proliferation: What else beyond water permeability?

2016

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In addition to the extensive data demonstrating the importance of mammalian AQPs for the movement of water and some small solutes across the cell membrane, there is now a growing body of evidence indicating the involvement of these proteins in numerous cellular processes seemingly unrelated, at least some of them in a direct way, to their canonical function of water permeation. Here, we have presented a broad range of evidence demonstrating that these proteins have a role in cell proliferation by various different mechanisms, namely, by allowing fast cell volume regulation during cell division; by affecting progression of cell cycle and helping maintain the balance between proliferation and apoptosis, and by crosstalk with other cell membrane proteins or transcription factors that, in turn, modulate progression of the cell cycle or regulate biosynthesis pathways of cell structural components. In the end, however, after discussing all these data that strongly support a role for AQPs in the cell proliferation process, it remains impossible to conclude that all these other functions attributed to AQPs occur completely independently of their water permeability, and there is a need for new experiments designed specifically to address this interesting issue.

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“…Th e aquaporins (AQPs), integral membrane proteins, have been shown to be expressed in multiple epithelial and endothelial transporting fl uids (Verkman 2005) as well as tumor cells (Moon et al 2003;Hu and Verkman 2006). In in vitro and in vivo, AQPs can also facilitate tumor cell migration across the blood vessels (Hu and Verkman 2006).…”

Section: Th E Eff Ect Of C Longa and Curcumin On The Female Reproducmentioning

confidence: 99%

The effects of Curcuma longa and curcumin on reproductive systems

Mohebbati

Anaeigoudari

Khazdair

2017

Endocrine Regulations

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Objective. Curcuma longa (C. longa) was used in some countries such as China and India for various medicinal purposes. Curcumin, the active component of C. longa, is commonly used as a coloring agent in foods, drugs, and cosmetics. C. longa and curcumin have been known to act as antioxidant, anti-infl ammatory, anti-mutagen, and anti-carcinogenic agents. Th e attempt of the present review was to give an eff ort on a detailed literature survey concentrated on the protective eff ects of C. longa and curcumin on the reproductive organs activity.Methods. Th e databases such as, PubMed, Web of Science, Google Scholar, Scopus, and IranMedex, were considered. Th e search terms were "testis" or "ovary" and "Curcuma longa", "curcumin", "antioxidant eff ect", "anti-infl ammatory eff ect" and "anti-cancer eff ect".Results. C. longa and curcumin inhibited the production of the tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2) and increased the caspases (3, 8 and 9) activities in HL-60 prostate cancer. Furthermore, C. longa and curcumin suppressed the vascular endothelial growth factor (VEGF), phosphorylated signal transducers and activators of the transcription 3 (STAT) and matrix metalloproteinase-9 (MMP-9) in ovarian cancer cell line.Conclusion. C. longa and curcumin might decrease the risk of cancer and other malignant diseases in the reproductive system. C. longa and curcumin have a protective eff ect on the reproductive organs activity such as, anti-infl ammatory, anti-apoptotic, and antioxidant eff ects in normal cells but showed pro-apoptotic eff ects in the malignant cells. Th erefore, diff erent eff ects of C. longa and curcumin are dependent on the doses and the type of cells used in various models studied.

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Involvement of aquaporins in colorectal carcinogenesis

Cited by 180 publications

References 23 publications

Overexpression of AQP5, a putative oncogene, promotes cell growth and transformation

Overexpression of AQP5, a putative oncogene, promotes cell growth and transformation

Role of aquaporins in cell proliferation: What else beyond water permeability?

The effects of Curcuma longa and curcumin on reproductive systems

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