Involvement of brain natriuretic peptide signaling pathway in the cardioprotective action of sitagliptin

Abbas, Samah S.; Mahmoud, Hesham; Schaalan, Mona F.; El‐Abhar, Hanan S.

doi:10.1016/j.pharep.2018.02.010

Cited by 11 publications

(7 citation statements)

References 52 publications

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“…Even though the sensitivity and specificity are likely to be insufficient, both peptides are promising prognostic markers in acute coronary syndromes 23 . Moreover, the escalation of these peptides correlates with the severity of aortic stenosis and cardiac ischemia/reperfusion injury 24 , 25 . Interestingly, it was reported that BNP elevation correlates with suppressing the gene expression of endothelin (ET)-1 and prevents the stimulation of several hypertrophic kinases, such as protein kinase C (PKC) 26 .…”

Section: Introductionmentioning

confidence: 99%

Activated ROCK/Akt/eNOS and ET-1/ERK pathways in 5-fluorouracil-induced cardiotoxicity: modulation by simvastatin

Muhammad

Sallam

El‐Abhar

2020

Sci Rep

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5-Fluorouracil (5-FU) is used in the treatment of different solid tumors; however, its use is associated with rare, but serious cardiotoxicity. Nevertheless, the involvement of ROCK/NF-κB, Akt/eNOS and ET-1/ERK1/2 trajectories in the cardiotoxic effect and in the potential cardioprotective upshot of simvastatin has been elusive. Male Wistar rats were allocated into 5-FU (50 mg/kg/week; i.p, 6 weeks), simvastatin (15 mg/kg/day; p.o, 8 weeks) treated groups and simvastatin + 5-FU, besides the normal control group. 5-FU-induced cardiotoxicity boosted the serum level of N-terminal pro-brain (B-type) natriuretic peptide (NT-proBNP), aortic contents of endothelin (ET)-1 and thromboxane (TX) A2, as well as cardiac contents of NADPH oxidases (Nox), cyclooxygenase (COX)-2, malondialdehyde (MDA), phosphorylated Akt (p-Akt), phosphorylated extracellular signal-regulated kinase (p-ERK)1/2 and the protein expressions of rho-kinase (ROCK) and caspase-3. On the other hand, it suppressed cardiac reduced glutathione (GSH) and phosphorylated endothelial nitric oxide synthase (p-eNOS). Contrariwise, co-administration with simvastatin overcame these disturbed events and modulated the ROCK/NF-κB, Akt/eNOS and ET-1/ERK1/2 signaling pathways. This study highlights other mechanisms than coronary artery spasm in the 5-FU cardiotoxicity and reveals that NT-proBNP is a potential early marker in this case. Moreover, the cross-talk between ROCK/ NF-κB, ROS/COX-2/TXA2, Akt/eNOS and ET-1/ERK1/2 pathways contributes via different means to upsetting the vasoconstriction/vasodilatation equilibrium as well as endothelial cell function and finally leads to cardiomyocyte stress and death—the modulation of these trajectories offers simvastatin its potential cardio-protection against 5-FU.

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Section: Introductionmentioning

confidence: 99%

Activated ROCK/Akt/eNOS and ET-1/ERK pathways in 5-fluorouracil-induced cardiotoxicity: modulation by simvastatin

Muhammad

Sallam

El‐Abhar

2020

Sci Rep

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“…Nonhemodynamic factors such as catecholamines and other neuroendocrines synthesize BNP [31]. In pregnant women, the mechanism of BNP secretion is insufficiently understood, but BNP may be secreted by diuretic action to reduce the volume and pressure overload on the myocardial wall [32,33]. In the present study, in singleton pregnancies, the higher the BNP level immediately after childbirth was, the lower the E/e' at PP2 (Fig.…”

Section: Discussionmentioning

confidence: 49%

Morphofunctional cardiac changes in singleton and twin pregnancies: a longitudinal cohort study

Umazume

Yamada

Furuta

et al. 2020

BMC Pregnancy Childbirth

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Background This study aimed to compare the echocardiographic changes and cardiac biomarkers between women with singleton and twin pregnancies. Methods From April 2014 to March 2016, this longitudinal cohort study invited pregnant women who were scheduled to give birth at Hokkaido University Hospital. We analyzed prospectively collected data on simultaneously determined echocardiographic parameters and blood cardiac markers of 44 women with singleton and 22 women with twin pregnancies. Furthermore, we tested the mixed-effect models for echocardiographic parameters and cardiac biomarkers. Results During the third trimester and immediately postpartum (within 1 week after childbirth), the mean left atrial volume index and brain natriuretic peptide (BNP) level were significantly higher in women with twin pregnancies than in those with singleton pregnancies. Women with twin pregnancies also had significantly smaller second-trimester inferior vena cava diameters and significantly higher third−trimester creatinine levels than those with singleton pregnancies. BNP positively correlated with the left atrial volume index (β = 0.49, p < 0.01) and the ratio of early diastolic transmitral to mitral annular velocity (E/e’) (β = 0.41, p < 0.01). At 1 month after childbirth in women with singleton pregnancies, BNP and N-terminal precursor protein BNP (NT-proBNP) fragments immediately postpartum negatively correlated with the later E/e’ (r = − 0.33, p = 0.02 and r = − 0.36, p < 0.01, respectively). Conclusions The intravascular cardiac load reached maximum within 1 week after childbirth and was greater in women with twin pregnancies than in those with singleton pregnancies. BNP/NT-proBNP significantly positively correlated with LA volume index and E/e’. In women with singleton pregnancies, BNP secreted immediately after childbirth might improve the diastolic functions 1 month after childbirth.

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“…Nonhemodynamic factors such as catecholamines and other neuroendocrines synthesize BNP [31]. In pregnant women, the mechanism of BNP secretion is insu ciently understood, but BNP may be secreted by diuretic action to reduce the volume and pressure overload on the myocardial wall [32,33]. In the present study, in singleton pregnancies, the higher the BNP level immediately after childbirth was, the lower the E/e' at PP2 (Fig.…”

Section: Discussionmentioning

confidence: 49%

Morphofunctional Cardiac Changes in Singleton and Twin Pregnancies: A Longitudinal Cohort Study

Umazume

Yamada

Furuta

et al. 2020

Preprint

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Background: This study aimed to compare the echocardiographic changes and cardiac biomarkers between women with singleton and twin pregnancies.Methods: From April 2014 to March 2016, this longitudinal cohort study invited pregnant women who were scheduled to give birth at Hokkaido University Hospital. We analyzed prospectively collected data on simultaneously determined echocardiographic parameters and blood cardiac markers of 44 women with singleton and 22 women with twin pregnancies. Furthermore, we tested the mixed-effect models for echocardiographic parameters and cardiac biomarkers.Results: During the third trimester and immediately postpartum (within 1 week after childbirth), the mean left atrial volume index and brain natriuretic peptide (BNP) level were significantly higher in women with twin pregnancies than in those with singleton pregnancies. Women with twin pregnancies also had significantly smaller second-trimester inferior vena cava diameters and significantly higher third-trimester creatinine levels than those with singleton pregnancies. BNP positively correlated with the left atrial volume index (β = 0.49, p < 0.01) and the ratio of early diastolic transmitral to mitral annular velocity (E/e') (β = 0.41, p < 0.01). At 1 month after childbirth in women with singleton pregnancies, BNP and N-terminal precursor protein BNP (NT-proBNP) fragments immediately postpartum negatively correlated with the later E/e' (r = −0.33, p = 0.02 and r = −0.36, p < 0.01, respectively).Conclusions: The intravascular cardiac load reached maximum within 1 week after childbirth and was greater in women with twin pregnancies than in those with singleton pregnancies. BNP/NT-proBNP significantly positively correlated with LA volume index and E/e'. In women with singleton pregnancies, BNP secreted immediately after childbirth might improve the diastolic functions 1 month after childbirth.

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Involvement of brain natriuretic peptide signaling pathway in the cardioprotective action of sitagliptin

Abstract: The results of the present study suggest that the cardioprotective effect of sitagliptin is mediated partly, but not solely, through the BNP/cGMP/PKG survival signaling pathway.

Cited by 11 publications

References 52 publications

Activated ROCK/Akt/eNOS and ET-1/ERK pathways in 5-fluorouracil-induced cardiotoxicity: modulation by simvastatin

Activated ROCK/Akt/eNOS and ET-1/ERK pathways in 5-fluorouracil-induced cardiotoxicity: modulation by simvastatin

Morphofunctional cardiac changes in singleton and twin pregnancies: a longitudinal cohort study

Morphofunctional Cardiac Changes in Singleton and Twin Pregnancies: A Longitudinal Cohort Study

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