2021
DOI: 10.1155/2021/5566453
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Involvement of circRNAs in Proinflammatory Cytokines-Mediated β-Cell Dysfunction

Abstract: Aim. During the initial stage of type 1 diabetes, prolonged exposure of pancreatic β-cell to proinflammatory cytokines such as IL-1β, TNF-α, and IFN-γ results in a decreased capacity to produce and release insulin, as well as cell loss by apoptosis. Circular RNAs (circRNAs) are a new class of endogenous noncoding RNAs (ncRNAs) with closed loop with no free ends. circRNAs have been reported to be participated in the development of many diseases. As little is known about their role in insulin-secreting cells, th… Show more

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Cited by 13 publications
(21 citation statements)
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“…GO and KEGG analysis of DEGs were performed to predict HMOX1 related cell metabolism and molecular interactions among genes. GO analysis contains three domains: biological process (BP), cellular component (CC) and molecular function (MF) ( 36 ). The top 30 enriched GO terms of GSE28829 were listed in Figure 6A .…”
Section: Resultsmentioning
confidence: 99%
“…GO and KEGG analysis of DEGs were performed to predict HMOX1 related cell metabolism and molecular interactions among genes. GO analysis contains three domains: biological process (BP), cellular component (CC) and molecular function (MF) ( 36 ). The top 30 enriched GO terms of GSE28829 were listed in Figure 6A .…”
Section: Resultsmentioning
confidence: 99%
“…They can also function as miRNA sponges, thereby inhibiting miRNA function. Our previous finding reported a group of dysregulated circRNAs in MIN6 cells with the stimulation of proinflammatory cytokines, including upregulated circRNA 006029 and 013053 and downregulated circRNA 000286 and 017277 [ 23 ]. Here, the four circRNAs were applied for constructing circRNA-mRNA coexpression network.…”
Section: Resultsmentioning
confidence: 99%
“…These lncRNAs may play key or partial roles in cytokine-mediated β -cell dysfunction by regulating mRNA expression. Moreover, by using the circRNA microarray data in our previous study [ 23 ], we constructed a circRNA-mRNA coexpression network and obtained that circRNAs may be implicated in β -cell dysfunction. Therefore, we speculate that the regulation of ncRNAs contributes to the changed mRNAs in proinflammatory cytokine-induced β -cell destruction.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…As shown above, diminished levels of circHIPK3 and CircRNA-CDR1as cause β cells to be unable to release enough insulin to meet the organism’s needs. CircRNA is involved in β cell dysfunction mediated by lipotoxic and pro-inflammatory cytokines ( Zhang et al, 2021 ; Wang et al, 2021b ). Wu et al ( Wu et al, 2020 ) revealed that circTulp4 regulated β-cell proliferation to lipotoxicity via the miR-7222-3p/soat1/cyclinD1 signaling pathway.…”
Section: Circrnas and Gdmmentioning
confidence: 99%