Involvement of Distinct Signaling Pathways in Activin-Induced Increases in FSH Secretion and Enlargement of FSH Cell Population in the Rat Pituitary.

Katayama, Tetsuro; Kyan, Hisako; Nakashima, M.; Rahayu, Emilliana Y.; Murakami, Noboru; Kuroda, Haruto

doi:10.1507/endocrj.47.239

Cited by 6 publications

(4 citation statements)

References 31 publications

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“…Numbers of rat anterior pituitary cells secreting FSH are increased by activin A through Ca 2+ -dependent mechanisms (44). CACNB2, along with other members of the calcium channel superfamily, might participate in the development of gonadotroph-producing FSH.…”

Section: Discussionmentioning

confidence: 99%

Genetic variants related to gap junctions and hormone secretion influence conception rates in cows

Sugimoto

Sasaki

Gotoh³

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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The recent decline in fertility is a serious problem in the dairy industry. To overcome this problem, we performed a genome-wide association study using 384 Holsteins and identified four loci associated with conception rates. Two of them contained gap junctionrelated genes: PKP2 and CTTNBP2NL. Further analysis confirmed that PKP2 increased connexin 43, a gap junction protein, whereas CTTNBP2NL dephosphorylated connexin 43. Knockdown of PKP2 or overexpression of CTTNBP2NL inhibited embryo implantation in mice. The other two loci contained neuroendocrine-related genes: SETD6 and CACNB2. Additional experiments indicated that SETD6 is involved in the transcriptional regulation of gonadotropin-releasing hormone, whereas CACNB2 controlled the secretion of folliclestimulating hormone in cattle. The total allele substitution effect of these genes on conception rate was 3.5%. Our findings reveal important roles for gap junction communication and the neuroendocrine system in conception and suggest unique selection methods to improve reproductive performance in the livestock industry.

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Section: Discussionmentioning

confidence: 99%

Genetic variants related to gap junctions and hormone secretion influence conception rates in cows

Sugimoto

Sasaki

Gotoh³

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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“…As follistatin is an activin-binding protein, high levels of follistatin within the pituitary would block activin stimulation of FSH transcription in gonadotrophs (Katayama et al, 2000).…”

Section: Discussion and Future Investigationsmentioning

confidence: 99%

“…Follistatin was known to inhibit FSH synthesis by binding activin and limiting activin signaling to gonadotrophs (Katayama et al, 2000). Furthermore, follistatin mRNA expression followed the same expression pattern as PACAP from PN17-PN29.…”

Section: Effects Of Pacap38 and Pacap Antagonist 6-38 On Gonadotropinmentioning

confidence: 93%

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PACAP : a novel neuropeptide for pituitary gonadotroph maturation, function and regulation.

Yang¹

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Histone deacetylase inhibitors suppress transdifferentiation of gonadotrophs to prolactin cells and proliferation of prolactin cells induced by diethylstilbestrol in male mouse pituitary

Nandar

Shibata

Soe

et al. 2018

Histochem Cell Biol

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Diethylstilbestrol (DES), an estrogen agonist, increases prolactin (PRL) cells through transdifferentiation of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) cells to PRL cells as well as proliferation of PRL cells in adult male mouse pituitary. Since hyperacetylation of histone H3 is implicated in the regulation of activation of various genes, we examined the effect of DES on the state of histone H3 acetylation. DES significantly reduced the immunohistochemical signal for acetylated histone H3 at lysine 9 (H3K9ac) in PRL, LH and FSH cells, but not for H3K18ac or H3K23ac. DES-treated mice were injected intraperitoneally with HDAC inhibitors (HDACi), sodium phenylbutyrate (NaPB) or valproic acid (VPA), to mimic the acetylation level of histone H3. As expected, HDACi treatment restored the level of H3K9ac expression in these cells, and also inhibited DES-induced increase in PRL cells. Furthermore, NaPB and VPA also abrogated the effects of DES on the population density of both LH and FSH cells. Similarly, the numbers of proliferating and apoptotic cells in the pituitary in NaPB-or VPA-treated mice were comparable to those of the control mice. Considered together, these results indicated that the acetylation level of histone H3 plays an important role in DES-induced transdifferentiation of LH to PRL cells as well as proliferation of PRL cells.

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Involvement of Distinct Signaling Pathways in Activin-Induced Increases in FSH Secretion and Enlargement of FSH Cell Population in the Rat Pituitary.

Cited by 6 publications

References 31 publications

Genetic variants related to gap junctions and hormone secretion influence conception rates in cows

Genetic variants related to gap junctions and hormone secretion influence conception rates in cows

PACAP : a novel neuropeptide for pituitary gonadotroph maturation, function and regulation.

Histone deacetylase inhibitors suppress transdifferentiation of gonadotrophs to prolactin cells and proliferation of prolactin cells induced by diethylstilbestrol in male mouse pituitary

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