Involvement of endogenous hydrogen sulfide in cigarette smoke-induced changes in airway responsiveness and inflammation of rat lung

Chen, Yahong; Wang, Peipei; Wang, Xin-Mao; He, Yuze; Yao, Wan-zhen; Qi, Yongcheng; Tang, Chaoshu

doi:10.1016/j.cyto.2010.12.006

Cited by 70 publications

(63 citation statements)

References 29 publications

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“…In a smoking-induced chronic COPD rat model, endogenous H 2 S exerted a protective function, reducing inflammation and bronchodilation. 26 Intraperitoneal injection of NaHS has been shown to alleviate rat airway hyper-responsiveness, as well as to reduce IL-8 and tumor necrosis factor alpha levels in rat lung tissues. Another study found that, in a mouse model of COPD, cystathionine ␥-lyase protein levels and the capacity for H 2 S synthesis in the lungs were significantly reduced.…”

Section: Discussionmentioning

confidence: 99%

Exhaled Hydrogen Sulfide Predicts Airway Inflammation Phenotype in COPD

et al. 2014

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BACKGROUND: The role of exhaled H 2 S as a marker of airway inflammation and its relationship with COPD severity remain to be determined. METHODS: Airway inflammation was classified in 77 COPD subjects based on the presence of inflammatory cells in induced sputum. We investigated the association between disease phenotype and exhaled H 2 S, lung function, and plasma levels of several inflammatory factors, including tumor necrosis factor alpha, interleukin-8, and leukotriene B 4 . RESULTS: In total, 33.77% of enrolled COPD subjects were diagnosed with eosinophilia. These subjects had a longer disease course, smoked fewer cigarettes, and experienced more frequent exacerbation events before study enrollment. However, they also had worse lung function and larger residual volume, they demonstrated greater changes in FEV 1 following bronchodilator inhalation. Although levels of plasma inflammatory factors did not significantly differ between subjects with and without eosinophilia, subjects without eosinophilia had significantly higher levels of exhaled H 2 S (9.19 ؎ 2.74 vs 7.24 ؎ 1.68 parts per billion, P ‫؍‬ .01). Furthermore, exhaled H 2 S levels were negatively correlated with induced sputum eosinophils (r ‫؍‬ ؊0.45, P ‫؍‬ .05), and positively correlated with inspiratory capacity in COPD subjects (r ‫؍‬ 0.51, P ‫؍‬ .026), but did not correlate significantly with plasma inflammatory factors. A cut-off value of 7.10 parts per billion of exhaled H 2 S predicted a non-eosinophilic phenotype with 68.6% sensitivity and 77.9% specificity. CONCLUSIONS: Exhaled levels of H 2 S were lower in subjects with eosinophilia. Increased levels of exhaled H 2 S predicted a non-eosinophilic phenotype in our study population. Key words: chronic obstructive pulmonary disease; airway inflammation phenotype; eosinophilia; hydrogen sulfide. [Respir Care 2015;60(2):251-258.

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Section: Discussionmentioning

confidence: 99%

Exhaled Hydrogen Sulfide Predicts Airway Inflammation Phenotype in COPD

et al. 2014

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“…11 Furthermore, H 2 S donors inhibited iNOs production by enhancing the expression of HO-1. 12 HO-1 is the major rate-limiting enzyme for the synthesis of endogenous CO, it can catalyze the degradation of heme into CO, catalytic iron and bilirubin. Catalytic iron and bilirubin have a strong capacity of anti-oxidation.…”

Section: Discussionmentioning

confidence: 99%

The analysis on the expression of gasotransmitters in early trauma patients

Wang

Fang

Guo

et al. 2017

Rev. Assoc. Med. Bras.

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Objective: Nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H 2 S) were endogenously-generated molecules gas. They owned important biological activity and participated in many pathophysiological processes. This study aimed to examine the levels of three gasotransmitters in the early phase of trauma patients. Method: Blood samples were collected from 60 trauma patients and ten healthy volunteers. Concentration of serum iNOS and HO-1 were analyzed by enzyme linked immunosorbent assay and plasma H 2 S was determined by colorimetric method. Meanwhile, the occurrence of multiple organ dysfunction syndrome (MODS) was also monitored. Results: The levels of iNOS, HO-1 and endogenous H 2 S in the patients group were significantly different from the healthy control group, and the difference was more obvious with the increase of ISS score. iNOS levels were positively correlated with ISS scores and blood lactic acid values, and HO-1 and endogenous H2S were negatively correlated with ISS scores and blood lactic acid values. Of 60 trauma patients, eight (13.33%) developed MODS. The level of iNOS in the MODS group was higher than that in non-MODS group, while HO-1 and H 2 S were significant lower in the MODS group. Conclusion: The three gasotransmitters participated in systemic inflammatory responses during early trauma and could be used as important indicators for trauma severity. Their measurements were meaningful for evaluating the severity and prognosis of trauma.

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“…Thirty male Sprague-Dawley rats (190-230 g) were randomly assigned to five groups (six rats per group) exposed to different amounts of 1,2-DCE in a HOPE-MED8050 automatic dynamic inhalation chamber (Tianjin Hope Industry&Trade Co.Ltd, China) (11). Group 1 was exposed to 4 g/m 3 for 1.5 h, group 2 to 4 g/m 3 for 4 h, group 3 to 12 g/m 3 for 1.5 h, and group 4 to 12 g/m 3 for 4 h. The control group was placed in a chamber for 4 hours but not exposed to 1,2-DCE.…”

Section: Methodsmentioning

confidence: 99%