Involvement of Inducible Costimulator Ligand (ICOSL) Expression in Thyroid Tissue in Hyperthyroidism of Graves’ Disease Patients

Wang, Fengming; Yan, Tao; Chen, Lüjun; Chen, Xuemin; Liu, Tong; Shen, Shuang; Li, Ting; Gao, Li; Wang, Ting; Sun, Jing; Liu, Cuiping; H, Wu; Zhang, Xueguang; Chen, Lei

doi:10.1007/s10875-012-9711-2

Cited by 9 publications

(4 citation statements)

References 34 publications

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“…Furthermore, co-signaling receptors can be expressed in non-antigen-presenting cells including T-cells. Despite the recognition of functions of co-signaling receptors in regulating T cell activation and their presence in nonantigen presenting cells, understanding of whether reverse signaling of these co-signaling receptors play roles in tissue physiology (20) and pathology (17,21) remains unclear. One of the reasons for the lack of knowledge in this area is that we do not know the overall expression patterns of these co-signaling receptors in tissues and in diseased conditions.…”

Section: Introductionmentioning

confidence: 99%

Co-signaling receptors regulate T-cell plasticity and immune tolerance

Shen

Nanayakkara

et al. 2019

Front Biosci

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We took an experimental database mining analysis to determine the expression of 28 co-signaling receptors in 32 human tissues in physiological/pathological conditions. We made the following significant findings: 1) co-signaling receptors are differentially expressed in tissues; 2) heart, trachea, kidney, mammary gland and muscle express co-signaling receptors that mediate CD4 + T cell functions such as priming, differentiation, effector, and memory; 3) urinary tumor, germ cell tumor, leukemia and chondrosarcoma express high levels of co-signaling receptors for T cell

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Section: Introductionmentioning

confidence: 99%

Co-signaling receptors regulate T-cell plasticity and immune tolerance

Shen

Nanayakkara

et al. 2019

Front Biosci

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“…ICOSLG-ICOS interaction is implicated in multiple immune processes, such as the establishment of CD8+ tissue resident T cells in intestine (64). Altogether, these interactions point to the importance of ICOS interactions, which have been found to have relevance in multiple autoimmune diseases (65)(66)(67).…”

Section: Discussionmentioning

confidence: 89%

Single-Cell RNA Sequencing of Peripheral Blood Mononuclear Cells From Pediatric Coeliac Disease Patients Suggests Potential Pre-Seroconversion Markers

et al. 2022

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Celiac Disease (CeD) is a complex immune disorder involving villous atrophy in the small intestine that is triggered by gluten intake. Current CeD diagnosis is based on late-stage pathophysiological parameters such as detection of specific antibodies in blood and histochemical detection of villus atrophy and lymphocyte infiltration in intestinal biopsies. To date, no early onset biomarkers are available that would help prevent widespread villous atrophy and severe symptoms and co-morbidities. To search for novel CeD biomarkers, we used single-cell RNA sequencing (scRNAseq) to investigate PBMC samples from 11 children before and after seroconversion for CeD and 10 control individuals matched for age, sex and HLA-genotype. We generated scRNAseq profiles of 9559 cells and identified the expected major cellular lineages. Cell proportions remained stable across the different timepoints and health conditions, but we observed differences in gene expression profiles in specific cell types when comparing patient samples before and after disease development and comparing patients with controls. Based on the time when transcripts were differentially expressed, we could classify the deregulated genes as biomarkers for active CeD or as potential pre-diagnostic markers. Pathway analysis showed that active CeD biomarkers display a transcriptional profile associated with antigen activation in CD4+ T cells, whereas NK cells express a subset of biomarker genes even before CeD diagnosis. Intersection of biomarker genes with CeD-associated genetic risk loci pinpointed genetic factors that might play a role in CeD onset. Investigation of potential cellular interaction pathways of PBMC cell subpopulations highlighted the importance of TNF pathways in CeD. Altogether, our results pinpoint genes and pathways that are altered prior to and during CeD onset, thereby identifying novel potential biomarkers for CeD diagnosis in blood.

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“…Upon activation of platelets by thrombin, adenosine diphosphate (ADP), or collagen, CD40L can be expressed on the surface of platelets. 15 Upon expression of CD40L on the surface of platelet membrane, CD40L could fall into the blood to form soluble CD40L (sCD40L). As the active form of CD40L, more than 95% of sCD40L in circulating blood is derived from activated platelets.…”

Section: Discussionmentioning

confidence: 99%

Serum CD40L, ST2, IL-6, and CRP serving as biomarkers for acute coronary syndrome

et al. 2022

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To analyze the diagnostic value of CD40 ligand (CD40L), soluble growth stimulating expression gene 2 protein (ST2), interleukin-6 (IL-6), and C-reactive protein (CRP) are used in patients with acute coronary syndrome (ACS). Serum samples were collected from 259 ACS patients admitted to our hospital. Additionally, 119 healthy individuals who received physical examination in the hospital at the same time period were included as normal control. The levels of CD40L, ST2, IL-6, and CRP in 259 patients with ACS and 119 healthy subjects were detected by ELISA. The levels of CD40L, ST2, IL-6, and CRP were significantly increased in unstable angina (UA) patients, while ST2, CRP, and IL-6 were significantly elevated in acute myocardial infarction (AMI) patients. Pearson correlation analysis showed that ST2 was also closely related to CRP in ACS patients, while ST2 was positively correlated with creatine kinase (CK), creatine kinase isoenzyme (CK-MB), and troponin I (cTnI) in AMI patients. The levels of glucose (GLU) and low-density lipoprotein cholesterol (LDL-c) were significantly decreased, while the levels of high-density lipoprotein cholesterol (HDL-c) were significantly increased in AMI patients treated with stent implantation. Furthermore, the level of serum CD40 L was significantly elevated in coronary heart disease (CHD) patients treated with stent implantation, while the levels of ST2 and IL-6 in AMI patients treated with the stent implantation decreased significantly. The levels of inflammatory factors significantly changed in patients with ACS. These inflammatory factors may involve in the pathological progression of ACS and can be used as diagnostic indexes for ACS.

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Involvement of Inducible Costimulator Ligand (ICOSL) Expression in Thyroid Tissue in Hyperthyroidism of Graves’ Disease Patients

Cited by 9 publications

References 34 publications

Co-signaling receptors regulate T-cell plasticity and immune tolerance

Co-signaling receptors regulate T-cell plasticity and immune tolerance

Single-Cell RNA Sequencing of Peripheral Blood Mononuclear Cells From Pediatric Coeliac Disease Patients Suggests Potential Pre-Seroconversion Markers

Serum CD40L, ST2, IL-6, and CRP serving as biomarkers for acute coronary syndrome

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