Involvement of Interleukin‐1 Genotypes in the Association of Coronary Heart Disease With Periodontitis

Geismar, Karen; Enevold, Christian; Sørensen, Lars Korsbæk; Gyntelberg, Finn; Bendtzen, Klaus; Sigurd, B; Holmstrup, Palle

doi:10.1902/jop.2008.070454

Cited by 38 publications

(22 citation statements)

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“…This is in accordance with other similar studies [67]. In this study, IL-1β -511 failed to demonstrate an association with periodontitis, which corresponds to four other studies to date [68,69]. The carriage rate of rare allele was the same in the patient and control groups.…”

Section: Discussionsupporting

confidence: 93%

Gene polymorphism and protein of human pro- and anti-inflammatory cytokines in Chinese healthy subjects and chronic periodontitis patients

et al. 2012

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BackgroundPeriodontal disease is thought to arise from the interaction of various factors, including the susceptibility of the host, the presence of pathogenic organisms, and the absence of beneficial species. The genetic factors may play a significant role in the risk of periodontal diseases. Cytokines initiate, mediate and control immune and inflammatory responses. The aim of this study is to compare genotypes and soluble protein of pro and anti-inflammatory cytokines (IL-1α, IL-1β, IL-6, IFN-γ, IL-10, TNF-α and IL-4) in subjects with or free of chronic periodontitis.MethodsA total of 1,290 Chinese subjects were recruited to this clinical trial: 850 periodontally healthy controls and 440 periodontal patients. All subjects were free of systemic diseases. Oral examinations were performed, and the following parameters were recorded for each subject: supragingival/subgingival calculus, gingival recession, bleeding on probing (BOP), probing depth (PD), clinical attachment loss (CAL), gingival recession and tooth mobility. The peripheral blood samples were collected for genetic and enzyme linked immunosorbent assay (ELISA) analysis. Restriction enzymes were used for digestion of amplified fragments of IL-1α, IL-1β, IL-6, IFN-γ, IL-10, TNF-α and IL-4.ResultsThe protein expressions of patient and control samples for IL-1α, IL-1β, IL-6, TNF-α, IFN-γ, IL-10, and IL-4 measured by ELISA confirmed a statistically significant difference (p < 0.001). The digestion of fragments of various genes showed that the pro-inflammatory cytokines IL-1α and TNF-α, and the anti-inflammatory cytokines IL-4 and IL-10 demonstrated a correlation with chronic inflammation in patients (X2: p < 0.001). The remaining genes investigated in patients and healthy subjects (IL-1β, IL-6, IFN-γ and IL-10) did not show any significant difference.ConclusionsThe cytokine gene polymorphisms may be used as a marker for periodontitis susceptibility, clinical behaviour and severity. This detection offers early diagnosis and induction of prophylaxis to other family members against disease progression.

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Section: Discussionsupporting

confidence: 93%

Gene polymorphism and protein of human pro- and anti-inflammatory cytokines in Chinese healthy subjects and chronic periodontitis patients

et al. 2012

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“…However, in our study, the CT genotype was not associated with periodontitis. A recent study of 219 Danish subjects 37 also found that the IL‐1B −511 C allele was associated with higher alveolar bone loss, and the T allele was associated with lower alveolar bone loss. The biologic basis for the association between IL‐1 polymorphisms and periodontitis is hypothesized to be that these polymorphisms may modulate the secretion of IL‐1β and −1α.…”

Section: Discussionmentioning

confidence: 90%

Interleukin‐1 Gene Cluster Polymorphisms Associated With Periodontal Disease in Type 2 Diabetes

López

Valenzuela

Jara

2009

Journal of Periodontology

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“…According to Asian [6], Japanese [39] and Brazilian [40] studies, the carriage rate in these populations was found to be lower than that reported for the Caucasian [35,41]. The lower carriage has also been reported in the Arab population where in Syrian Arabs, the rate was 12.5% and 8.6% in chronic periodontitis and controls [42].…”

Section: Discussionmentioning

confidence: 79%

Genetic polymorphisms in IL-1A and IL-1B isoforms and their associations with chronic periodontitis in the Swahili people of Kenya

Wagaiyu¹,

Bulimo²,

Wanzala³

et al. 2014

IOSRJDMS

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Involvement of Interleukin‐1 Genotypes in the Association of Coronary Heart Disease With Periodontitis

Abstract: Allele 1 of IL-1RN VNTR may be associated with the coexistence of CHD and PE in a multiple regression model.

Cited by 38 publications

References 68 publications

Gene polymorphism and protein of human pro- and anti-inflammatory cytokines in Chinese healthy subjects and chronic periodontitis patients

Gene polymorphism and protein of human pro- and anti-inflammatory cytokines in Chinese healthy subjects and chronic periodontitis patients

Interleukin‐1 Gene Cluster Polymorphisms Associated With Periodontal Disease in Type 2 Diabetes

Genetic polymorphisms in IL-1A and IL-1B isoforms and their associations with chronic periodontitis in the Swahili people of Kenya

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