Involvement of Lysosomal Enzymes in Flutamide-Induced Stimulation of Rat Testis

Mathur, Premendu P.; Chattopadhyay, Santanu

doi:10.1111/j.1439-0272.1982.tb03120.x

Cited by 32 publications

(22 citation statements)

References 15 publications

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“…The weights of the testis and epididymis largely dependent on the mass of the differentiated spermatogenic cells and requires continuous androgenic stimulation . It is observed that administration of mancozeb significantly decreased testicular sperm production and epididymal sperm density.…”

Section: Discussionsupporting

confidence: 90%

Forskolin ameliorates mancozeb‐induced testicular and epididymal toxicity in Wistar rats by reducing oxidative toxicity and by stimulating steroidogenesis

Girish

Reddy

2017

J Biochem & Molecular Tox

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In the present study, we have tested the beneficial effects of forskolin in protecting the mancozeb-induced reproductive toxicity in rats. Adult male Wistar rats were exposed to either mancozeb (500 mg/kg body weight/day) or forskolin (5 mg/kg body weight/day) or both for 65 days and analyzed for spermatogenesis and steroidogenesis and testicular and epididymal oxidative toxicity. A significant decrease in daily sperm production, epididymal sperm count, motile, viable, and hypo-osmotic swelling-tail swelled sperm was observed in mancozeb-treated rats. The activity levels of testicular 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase and circulatory testosterone levels were significantly decreased in mancozeb-treated rats. Exposure to mancozeb resulted in a significant decrease in glutathione levels and superoxide dismutase and catalase activity levels with an increase in lipid peroxidation levels in the testes and epididymis. Coadministration of forskolin mitigated the mancozeb-induced oxidative toxicity and suppressed steroidogenesis and spermatogenesis.

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Section: Discussionsupporting

confidence: 90%

Forskolin ameliorates mancozeb‐induced testicular and epididymal toxicity in Wistar rats by reducing oxidative toxicity and by stimulating steroidogenesis

Girish

Reddy

2017

J Biochem & Molecular Tox

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“…In the testis, acid phosphatase is widely distributed in lysosomes of Sertoli cells, spermatogonia and late spermatids (Chemes, 1986). Activities of free lysosomal enzymes have been shown to rise when testicular steroidogenesis is increased (Mathur & Chattopadhyay, 1982). In this study, the decrease in acid phosphatase activity might reflect decreased testicular function in the treated mice, and therefore, may interfere with the secretion of testosterone.…”

Section: Discussionmentioning

confidence: 87%

Toxicological assessment of Diplazium esculentum on the reproductive functions of male Swiss albino mouse

Roy

Chaudhuri

2016

Drug and Chemical Toxicology

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“…However, the increased ACP activity has been observed in the liver at the concentration of 200, 250, and 300 mg of T. terrestris extract. Mathur and Chattopadhyay (1982) demonstrated that the activities of phosphatases enzymes have been shown to rise when testicular steroidogenesis is increased.…”

Section: Discussionmentioning

confidence: 97%

Influence of Tribulus terrestris on testicular enzyme in fresh water ornamental fish Poecilia latipinna

Kavitha

Subramanian

2011

Fish Physiol Biochem

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The influence of Tribulus terrestris on the activities of testicular enzyme in Poecilia latipinna was assessed in lieu of reproductive manipulation. Different concentrations of (100, 150, 200, 250, and 300 mg) Tribulus terrestris extract and of a control were tested for testicular activity of enzymes in Poecilia latipinna for 2 months. The testis and liver were homogenized separately in 0.1 mol/l potassium phosphate buffer (0.1 mol/l, pH 7.2). The crude homogenate was centrifuged, and supernatant obtained was used as an enzyme extract for determination of activities. The activities of testicular functional enzyme ALP, ACP, SDH, LDH, and G6PDH levels were changed to different extent in treated groups compared with that of the control. The total body weight and testis weight were increased with the Tribulus terrestris-treated fish (Poecilia latipinna). These results suggest that Tribulus terrestris induced the testicular enzyme activity that may aid in the male reproductive functions. It is discernible from the present study that Tribulus terrestris has the inducing effect on reproductive system of Poecilia latipinna.

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Involvement of Lysosomal Enzymes in Flutamide-Induced Stimulation of Rat Testis

Cited by 32 publications

References 15 publications

Forskolin ameliorates mancozeb‐induced testicular and epididymal toxicity in Wistar rats by reducing oxidative toxicity and by stimulating steroidogenesis

Forskolin ameliorates mancozeb‐induced testicular and epididymal toxicity in Wistar rats by reducing oxidative toxicity and by stimulating steroidogenesis

Toxicological assessment of Diplazium esculentum on the reproductive functions of male Swiss albino mouse

Influence of Tribulus terrestris on testicular enzyme in fresh water ornamental fish Poecilia latipinna

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