Toxicological assessment of <i>Diplazium esculentum</i> on the reproductive functions of male Swiss albino mouse

Roy, Swarnendu; Chaudhuri, Tapas Kumar

doi:10.1080/01480545.2016.1190739

Cited by 8 publications

(7 citation statements)

References 30 publications

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“…The toxicological impact of D. esculentum on male reproductive functions of Swiss albino mice has been reported [105]. A total of 120 male Swiss albino mice of 6-8 weeks of age were fed orally with 80, 160, and 320 mg/kg b.w.…”

Section: Oxidative Medicine and Cellular Longevitymentioning

confidence: 99%

Diplazium esculentum (Retz.) Sw.: Ethnomedicinal, Phytochemical, and Pharmacological Overview of the Himalayan Ferns

Semwal

Painuli

et al. 2021

Oxidative Medicine and Cellular Longevity

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The genus Diplazium (family: Athyriaceae) comprises approximately 350 species of pteridophytes. Diplazium esculentum (Retz.) Sw. is an important member of this genus and commonly known as a wild vegetable in the Himalayan and sub-Himalayan communities. According to the literature analysis, D. esculentum was traditionally used for the prevention or treatment of several diseases such as diabetes, smallpox, asthma, diarrhea, rheumatism, dysentery, headache, fever, wounds, pain, measles, hypertension, constipation, oligospermia, bone fracture, and glandular swellings. Various extracts of D. esculentum were evaluated to elucidate their phytochemical and pharmacological activities. A wide array of pharmacological properties such as antioxidant, antimicrobial, antidiabetic, immunomodulatory, CNS stimulant, and antianaphylactic activities have been recognized in different parts of D. esculentum. The review covers a systematic examination of pharmacognosy, phytochemistry, and pharmacological applications of D. esculentum, but scientifically, it is not fully assessed regarding complete therapeutic effects, toxicity, and safety in the human body. The published literature on D. esculentum and its therapeutic properties were collected from different search engines including Wiley online, PubMed, Springer Link, Scopus, Science Direct, Web of Science, Google Scholar, and ACS publications by using specific terms such as “Diplazium esculentum, bioactive compounds, biological activities and health benefits” from 1984 to 2021 (March). Therefore, further studies are required to identify the detailed action mechanism of D. esculentum in vitro/in vivo, and also, more studies should focus on conservation, cultivation, and sustainable utilization of the species.

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Section: Oxidative Medicine and Cellular Longevitymentioning

confidence: 99%

Diplazium esculentum (Retz.) Sw.: Ethnomedicinal, Phytochemical, and Pharmacological Overview of the Himalayan Ferns

Semwal

Painuli

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…The sub-chronic and chronic treatments at the dose of 320 mg/kg body of D. esculentum have been reported to cause 100% fertility losses. Similarly, 100% losses of fecundity were observed in mice that were treated with 160 and 320 mg/kg bw of BDE for 180 days (Roy & Chaudhuri, 2017).…”

Section: Effect Of D Esculentum On the Reproductive Functionsmentioning

confidence: 91%

“…Significant decreases in the glycogen-, protein-, sialic acid-, and citric acid contents have also been observed in D. esculentum fed mice. Moreover, it was proposed that significant decrease in the prostatic citric acid level along with the decreased acid phosphatase level in testis might alter the testosterone level in D. esculentum treated mice (Roy & Chaudhuri, 2017). D. esculentum caused various structural abnormalities in testis as indicated by the histological examinations.…”

Section: Effect Of D Esculentum On the Reproductive Functionsmentioning

confidence: 99%

“…All these changes could halt the normal spermatogenesis at the primary spermatocytic cycle. Not only that, these alterations were proposed to hamper mitochondrial-, and plasma membrane, and junctional complexes between the adjacent Sertoli cells (Roy & Chaudhuri, 2017). D. esculentum has been reported to decrease the fertility as well as fecundity in Swiss albino mice in a dose-and time-dependent manner when compared to the respective control groups.…”

Section: Effect Of D Esculentum On the Reproductive Functionsmentioning

confidence: 99%

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A comprehensive review on the pharmacological properties of Diplazium esculentum, an edible fern

Chaudhuri¹,

Roy²

2020

JPPR

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Diplazium esculentum (Family: Athyriaceae), one of the most popular wild edible fern, is considered as a pharmacologically diverse ethnomedicinal plant. The coiled fronds and young leaves of this plant have a wide range ethnomedicinal uses in folk medicine around the world directed for a number of ailments. The present article is the first comprehensive review on the pharmacological activities of this particular edible fern. The structural formulas of all the chemical constituents identified and isolated so far from D. esculentum are also provided in the present review. The most thoroughly studied pharmacological activities viz., antioxidant, antimicrobial, immunomodulatory, neuromodulatory, anti-fertility, cytotoxic, etc.) of the D. esculentum extracts have been discussed. This comprehensive review will be of help for the future researchers investigating for more potent compounds and their pharmacological activities.

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“…Leaves used as vegetables; dried rhizomes are used as an insecticide, decoction of this plant is used in the treatment of cough and sometimes as a tonic (Chawala et al 2015) providing the basic needs, this fern have got considerable anti-inflammatory and antihepatoprotective activities (Nair et al 2015) and also significant cytotoxic, anti-microbial, antioxidant properties (Akter et al 2014). However, a study revealed, even after cooking, this fern may induce infertility to the male reproductive system (Roy and Choudhuri, 2015). Another study reported that daily consumption of the fern was found to elevate the risk of esophageal cancer (Somvanshi et al 2006).…”

Section: Ethanobotanical Usesmentioning

confidence: 99%

Diversity of Some Important Wild Edible Plants of Kumaun Uttarakhand: A Review

Nisha

Rao

2021

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Plants are the invaluable, incredible and traditional sources for the curability of various diseases in the form of medicines. Wild food plants, particularly wild fruits, have been an important element in the dietary traditions since the beginning of human civilization. The consumption of locally grown species is gaining an increasing interest, which also gives an important contribution to local communities’ health and welfare. In addition, wild fruits contain higher amounts of nutrients and bioactive compounds than many cultivated species. Fruits play at potential role in uplifting the economic condition as well as providing the food security to the local people. The tribal population stores a vast knowledge on utilization of local plants as food and other specific uses. Uttarakhand has very rich biodiversity also its diverse geographical area attract many people towards it in tourism. Wild edible fruit plants have traditionally occupied an important position in the socio-cultural, spiritual and health area of rural and tribal lives. Because in Uttarakhand theses wild fruits helps in health benefits many of them have medicinal importance, also theses fruits are part of source of income.

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Toxicological assessment of Diplazium esculentum on the reproductive functions of male Swiss albino mouse

Abstract: These results suggest that the intake of D. esculentum, even after cooking, may induce infertility by altering the male reproductive function, and therefore, should be evaluated further as a potential antifertility agent.

Cited by 8 publications

References 30 publications

Diplazium esculentum (Retz.) Sw.: Ethnomedicinal, Phytochemical, and Pharmacological Overview of the Himalayan Ferns

Diplazium esculentum (Retz.) Sw.: Ethnomedicinal, Phytochemical, and Pharmacological Overview of the Himalayan Ferns

A comprehensive review on the pharmacological properties of Diplazium esculentum, an edible fern

Diversity of Some Important Wild Edible Plants of Kumaun Uttarakhand: A Review

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