Involvement of Monkey Inferior Colliculus in Spatial Hearing

Zwiers, Marcel P.; Versnel, Huib; Opstal, A. John Van

doi:10.1523/jneurosci.0199-04.2004

Cited by 92 publications

(135 citation statements)

References 54 publications

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“…Transient eccentric eye position (Ͻ5 s) has also been shown to modulate the spatial responses of auditory neurons in the inferior colliculus (Groh et al, 2001;Zwiers et al, 2004), superior colliculus (Jay and Sparks, 1987;Hartline et al, 1995;Peck et al, 1995;Zella et al, 2001;Populin et al, 2004), auditory cortex (WernerReiss et al, 2003;Fu et al, 2004), and the intraparietal sulcus (Stricanne et al, 1996;Mullette-Gillman et al, 2005). These short-term effects may reflect a step in the eye-to-head-centered transformation of sound source coordinates, their associated errors, or an early component of the auditory spatial adaptation reported here.…”

Section: Discussionsupporting

confidence: 50%

Auditory Spatial Perception Dynamically Realigns with Changing Eye Position

Razavi¹,

O’Neill²,

Paige³

2007

J. Neurosci.

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Audition and vision both form spatial maps of the environment in the brain, and their congruency requires alignment and calibration. Because audition is referenced to the head and vision is referenced to movable eyes, the brain must accurately account for eye position to maintain alignment between the two modalities as well as perceptual space constancy. Changes in eye position are known to variably, but inconsistently, shift sound localization, suggesting subtle shortcomings in the accuracy or use of eye position signals. We systematically and directly quantified sound localization across a broad spatial range and over time after changes in eye position. A sustained fixation task addressed the spatial (steady-state) attributes of eye position-dependent effects on sound localization. Subjects continuously fixated visual reference spots straight ahead (center), to the left (20°), or to the right (20°) of the midline in separate sessions while localizing auditory targets using a laser pointer guided by peripheral vision. An alternating fixation task focused on the temporal (dynamic) aspects of auditory spatial shifts after changes in eye position. Localization proceeded as in sustained fixation, except that eye position alternated between the three fixation references over multiple epochs, each lasting minutes. Auditory space shifted by ϳ40% toward the new eye position and dynamically over several minutes. We propose that this spatial shift reflects an adaptation mechanism for aligning the "straight-ahead" of perceived sensory-motor maps, particularly during early childhood when normal ocular alignment is achieved, but also resolving challenges to normal spatial perception throughout life.

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Section: Discussionsupporting

confidence: 50%

Auditory Spatial Perception Dynamically Realigns with Changing Eye Position

Razavi¹,

O’Neill²,

Paige³

2007

J. Neurosci.

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“…The eyes were in different positions during these two time periods, so in principle, this test could have picked up neurons based on their eye-position sensitivity (Groh et al, 2001;Zwiers et al, 2004). However, this test was conducted on pooled data involving both leftward and rightward saccades to sounds, which would have tended to minimize the contribution of eye-position sensitivity to the population of neurons selected by this means.…”

Section: Resultsmentioning

confidence: 99%

Effects of Reward and Behavioral Context on Neural Activity in the Primate Inferior Colliculus

2006

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Neural activity in the inferior colliculus (IC) likely plays an integral role in the processing of various auditory parameters, such as sound location and frequency. However, little is known about the extent to which IC neural activity may be influenced by the context in which sounds are presented. In this study, we examined neural activity of IC neurons in the rhesus monkey during an auditory task in which a sound served as a localization target for a saccade. Correct performance was rewarded, and the magnitude of the reward was varied in some experiments. Neural activity was also assessed during a task in which the monkey maintained fixation of a light while ignoring the sound, as well as when sounds were presented in the absence of any task. We report that neural activity increased late in the trial in the saccade task in 58% of neurons and that the level of activity throughout the trials could be modulated by reward magnitude for many neurons. The late-trial neural activity similarly increased in the fixation task in 39% of the neurons tested for this task but was not observed when sounds were presented in the absence of a behavioral task and reward. Together, these results suggest that a rewardrelated signal influences neural activity in the IC.

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“…However, speech cues arguably require higher processing levels in the auditory pathway than soundsource localization. It is unclear whether subcortical stages in the auditory system, which are known to process the sound-localization cues, like the superior olivary complex, dorsal cochlear nucleus, and inferior colliculus (Yin 2002;Young and Davis 2002;Zwiers et al 2004) may be affected in older adults.…”

Section: Older Listenersmentioning

confidence: 99%

Age-related Hearing Loss and Ear Morphology Affect Vertical but not Horizontal Sound-Localization Performance

Otte

Agterberg

Wanrooij

et al. 2013

JARO

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Several studies have attributed deterioration of sound localization in the horizontal (azimuth) and vertical (elevation) planes to an age-related decline in binaural processing and high-frequency hearing loss (HFHL). The latter might underlie decreased elevation performance of older adults. However, as the pinnae keep growing throughout life, we hypothesized that larger ears might enable older adults to localize sounds in elevation on the basis of lower frequencies, thus (partially) compensating their HFHL. In addition, it is not clear whether sound localization has already matured at a very young age, when the body is still growing, and the binaural and monaural sound-localization cues change accordingly. The present study investigated sound-localization performance of children (7-11 years), young adults (20-34 years), and older adults (63-80 years) under open-loop conditions in the two-dimensional frontal hemifield. We studied the effect of age-related hearing loss and ear size on localization responses to brief broadband sound bursts with different bandwidths. We found similar localization abilities in azimuth for all listeners, including the older adults with HFHL. Sound localization in elevation for the children and young adult listeners with smaller ears improved when stimuli contained frequencies above 7 kHz. Subjects with larger ears could also judge the elevation of sound sources restricted to lower frequency content. Despite increasing ear size, sound localization in elevation deteriorated in older adults with HFHL. We conclude that the binaural localization cues are successfully used well into later stages of life, but that pinna growth cannot compensate the more profound HFHL with age.

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Involvement of Monkey Inferior Colliculus in Spatial Hearing

Cited by 92 publications

References 54 publications

Auditory Spatial Perception Dynamically Realigns with Changing Eye Position

Auditory Spatial Perception Dynamically Realigns with Changing Eye Position

Effects of Reward and Behavioral Context on Neural Activity in the Primate Inferior Colliculus

Age-related Hearing Loss and Ear Morphology Affect Vertical but not Horizontal Sound-Localization Performance

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