Involvement of NMDA receptors in the antidepressant-like effect of tramadol in the mouse forced swimming test

Ostadhadi, Sattar; Norouzi-Javidan, Abbas; Chamanara, Mohsen; Akbarian, Reyhaneh; Imran-Khan, Muhammad; Ghasemi, Mehdi; Dehpour, Ahmad Reza

doi:10.1016/j.brainresbull.2017.07.016

Cited by 31 publications

(20 citation statements)

References 57 publications

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“…As a result of this antidepressant effect, some of the participants of our study often abuse the drug each time they get worried, as the drug gives them hope and makes them feel happy as if they have won a lottery, according to the participants. This finding supports existing literature on the antidepressant effect of tramadol (Kalra, Tayal, & Chawla, ; Ostadhadi et al, ; Rougemont‐Bücking et al, ; Tetsunaga et al, ). In a systematic review, Rougemont‐Bücking et al () reported the case of two people who witnessed a significant improvement in their mood after taking a prescription of tramadol for the management of their pain.…”

Section: Discussionsupporting

confidence: 90%

Facilitators to the continuous abuse of tramadol among the youth: A qualitative study in Northern Ghana

et al. 2019

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Study aimConsidering the alarming rate at which young people abuse tramadol, as evidenced by the numerous media reports on the subject, this qualitative study was conducted to explore the facilitators to the abuse of tramadol by young people.Design and methodsA qualitative exploratory descriptive design was employed in conducting the study. A total of 18 participants were purposively sampled. Data for the study were collected through two focused group discussions and three in‐depth‐interviews. Thematic analysis was used to analyse the data.ResultsThe findings of the study revealed four main themes. These themes were initiating factors of abuse; desirable physical effects; desirable psychological effects; and undesirable effects. It was revealed that many young people initially get into tramadol abuse because of peer pressure, curiosity or post‐traumatic addiction. However, they often continue the practice for various physical and psychological gratifications including euphoria, attentiveness, high energy levels, pain relief and improved sexual performance. The study also revealed some unpleasant side effects of tramadol abuse such as severe vomiting, loss of appetite, seizures, emotional aloofness and irritability. Many of the participants in this study also expressed willingness to quit tramadol abuse because of social discrimination and the enormous side effects that come with the abuse of the drug.

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Section: Discussionsupporting

confidence: 90%

Facilitators to the continuous abuse of tramadol among the youth: A qualitative study in Northern Ghana

et al. 2019

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“…Over the last three years, the FST has been used as the main test for evaluating both the modelling and drug-therapeutic efficiency. However, the main problem with the studied drugs, including fluoxetine, tipepidine, and tramadol, was the low statistical power for clinical applications, which may not provide a direction for meta-analyses [91,92,93].…”

Section: Behavioral Testsmentioning

confidence: 99%

Selecting an Appropriate Animal Model of Depression

Hao

Sun

et al. 2019

IJMS

174

112

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Depression has become one of the most severe psychiatric disorders and endangers the health of living beings all over the world. In order to explore the molecular mechanism that underlies depression, different kinds of animal models of depression are used in laboratory experiments. However, a credible and reasonable animal model that is capable of imitating the pathologic mechanism of depression in mankind has yet to be found, resulting in a barrier to further investigation of depression. Nevertheless, it is possible to explain the pathologic mechanism of depression to a great extent by a rational modeling method and behavioral testing. This review aims to provide a reference for researchers by comparing the advantages and disadvantages of some common animal depression models.

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“…However, the mechanism through which tramadol improves sexual performance and cures premature ejaculation and ejaculation related issues were not known to the participants though empirical studies demonstrate that the relationship between tramadol and sexual function appears to be controversial [16,50]. Though the body of evidence evaluating tramadol for a sexual function is relatively small but uniformly demonstrates that it is an effective treatment [16,45,50,[52][53][54][55] which supports our study participants' claim the drug is effective for improving sexual performance and treating ejaculation issues. However, the use of tramadol for managing premature ejaculation and ejaculation related distress has been cautioned [56,57].…”

Section: Relation To Previous Studies and Possible Explanationsmentioning

confidence: 99%

“With tramadol, I ride like a Jaguar”: a qualitative study of motivations for non-medical purpose tramadol use among commercial vehicle operators in Kumasi, Ghana

Peprah

Agyemang-Duah

Appiah-Brempong

et al. 2020

Subst Abuse Treat Prev Policy

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Background: The misuse of tramadol has become a major aspect of the wider substance use challenge in recent years and is evolving into a health crisis at an alarming rate. However, literature on motivations for non-medical purpose tramadol use among commercial vehicle operators remains inadequate. The aim of this study was to document the motivations for non-medical purposes tramadol use in Kumasi. Such an understanding could inform policy direction to regulate non-medical purposes tramadol use in Ghana. Methods: We conducted this exploratory qualitative study with 23 purposively selected commercial vehicle drivers (15) and assistants (8) in Kumasi, Ghana. Data for the study were collected through in-depth face-to-face interviews between June 2018 and March 2019. Using a thematic analytical approach, the interviews were coded and analysed. Results: Multiple motivations for non-medical purposes tramadol use were found including those related to: (1) sexual; (2) psychological; (3) physical; and (4) economic factors. Participants also reported three main inter-linking categories of perceived tramadol adverse effects: (1) physical; (2) psychological; and (3) social effects. Although participants indicated no plans for stopping their non-medical use of tramadol any time soon, strong willingness was voiced for supporting officials in finding and dealing with non-medical purpose tramadol sellers. Conclusion: Non-medical purposes tramadol use was associated with a confluence of factors, ranging from enhanced sexual performance to economic reasons. Based on the findings of the study and the dependence and addictive potentials of tramadol, there is the need for psychoeducational programmes for persons who misuse tramadol and enhancement of operational capacities of regulatory agencies.

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Involvement of NMDA receptors in the antidepressant-like effect of tramadol in the mouse forced swimming test

Cited by 31 publications

References 57 publications

Facilitators to the continuous abuse of tramadol among the youth: A qualitative study in Northern Ghana

Facilitators to the continuous abuse of tramadol among the youth: A qualitative study in Northern Ghana

Selecting an Appropriate Animal Model of Depression

“With tramadol, I ride like a Jaguar”: a qualitative study of motivations for non-medical purpose tramadol use among commercial vehicle operators in Kumasi, Ghana

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