Involvement of oxidative stress in seizures induced by diphenyl diselenide in rat pups

Prigol, Marina; Wilhelm, Ethel A.; Schneider, Caroline C.; Rocha, João Batista Teixeira da; Nogueira, Cristina W.; Zeni, Gilson

doi:10.1016/j.brainres.2007.01.126

Cited by 38 publications

(21 citation statements)

References 33 publications

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“…We have observed that intraperitoneal administration of DPDS dissolved in DMSO can cause convulsion in mice (Brito et al 2006). Recent reports from our group also show that DPDS inhibits cerebral ALA-D and Na + /K + -ATPase in vitro (Kade et al 2008), and that DPDS causes seizures, with attendant increases in oxidative stress parameters in the brains of rat pups, further indicating the possible mechanism of its neurotoxicity (Prigol et al 2007). Such additional effects notwithstanding, the present study demonstrated that the treatment of diabetic rats with oral administration of DPDS in soya bean oil at 3 mg/kg exerted a considerable hypoglycemic effect.…”

Section: Discussionmentioning

confidence: 76%

Effect of oral administration of diphenyl diselenide on antioxidant status, and activity of delta aminolevulinic acid dehydratase and isoforms of lactate dehydrogenase, in streptozotocin-induced diabetic rats

et al. 2008

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Male albino rats with diabetes induced by the administration of streptozotocin (STZ) (45 mg/kg, i.v.) were treated with oral administration of diphenyl diselenide (DPDS) pre-dissolved in soya bean oil. A significant reduction in blood glucose levels was observed in STZ-induced diabetic rats treated with DPDS compared with an untreated STZ diabetic group. The pharmacological effect of DPDS was accompanied by a marked reduction in the level of glycated proteins, and restoration of the observed decreased levels of vitamin C and reduced glutathione (GSH; in liver and kidney tissues) of STZ-treated rats. DPDS also caused a marked reduction in the high levels of thiobarbituric acid reactive substances (TBARS) observed in STZ-induced diabetic group. Finally, the inhibition of catalase, delta aminolevulinic acid dehydratase (eth-ALA-D) and isoforms of lactate dehydrogenase (LDH) accompanied by hyperglycemia were prevented by DPDS in all tissues examined. Hence, in comparison with our earlier report, the present findings suggests that, irrespective of the route of administration and the delivery vehicle, DPDS can be considered as an anti-diabetic agent due to its anti-hyperglycemic and antioxidant properties.

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Section: Discussionmentioning

confidence: 76%

Effect of oral administration of diphenyl diselenide on antioxidant status, and activity of delta aminolevulinic acid dehydratase and isoforms of lactate dehydrogenase, in streptozotocin-induced diabetic rats

et al. 2008

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“…11, 2010 activity in rats, suggesting that the inhibitory effect is not species-dependent for rodents. 27,45 However, in contrast with the results obtained with mice the inhibition in δ-ALA-D activity neither impact in hematocrit nor in hemoglobin concentration. 46 The potential inhibitory effect of diphenyl diselenide on δ-ALA-D activity was investigated in rabbits as well.…”

Section: Protein-ssg + Gshmentioning

confidence: 72%

“…26 Additionally, strong evidence has been accumulated indicating that diphenyl diselenide presents convulsant activity. 27 The appearance of seizures and the plasmatic level of diphenyl diselenide are dependent on the administration route (i.p. > p.o.…”

Section: General Toxicitymentioning

confidence: 99%

Diphenyl diselenide a janus-faced molecule

Nogueira

Rocha

2010

J. Braz. Chem. Soc.

203

106

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Este artigo de revisão aborda uma reflexão sobre o potencial terapêutico ou tóxico de compostos orgânicos de selênio, dando particular ênfase ao disseleneto de difenila e alguns dos seus análogos estruturais. Algumas características moleculares relacionadas com a toxicidade e farmacologia do disseleneto de difenila in vitro e in vivo são abordadas. Os artigos revisados, que abordam experimentos in vivo, indicam que a interação do disseleneto de difenila com tióis pode determinar seu potencial farmacológico ou toxicológico. Além disso, uma limitada ativação da rota de toxicidade, isto é, a oxidação controlada de moléculas de alto peso molecular, que contém grupos tióis, poderia contribuir para os efeitos farmacológicos do disseleneto de difenila. Concluise que a síntese de compostos orgânicos de selênio deve ser direcionada para o desenvolvimento de novos disselenetos de diorganoila que possam interagir com alvos moleculares específicos.In this review, we summarized the potential role of synthetic organoseleno compounds as therapeutic or toxic agents, giving emphasis almost exclusively to diphenyl diselenide, the simplest of the diaryl diselenides, and some of its analogs. We presented the main molecular aspects related to the in vitro toxicity and pharmacology of diphenyl diselenide and also provided in vivo data indicating that the interaction of diphenyl diselenide with thiols can dictate either its toxicological or pharmacological property. The papers covered in this review indicate that a limited activation of the "toxic pathway", i.e., a controlled oxidation of specific high molecular weight thiol-containing molecules could contribute to the pharmacological effects of diphenyl diselenide. In conclusion, this review reinforces the necessity of developing new diorganoyl diselenides that could interact with specific molecular targets.

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“…The results presented in this report showed that the appearance of seizure episodes induced by pilocarpine occurred in association with inhibition of d-ALA-D activity, suggesting that seizures, oxidative stress, and d-ALA-D activity are linked events. Accordingly, previous studies demonstrated that d-ALA-D activity was inhibited during seizures (Prigol et al 2007). This finding suggests that decrease in hippocampal d-ALA-D activity is probably during seizures induced by pilocarpine in adult rats.…”

Section: Discussionmentioning

confidence: 93%

Lipoic Acid Alters δ-Aminolevulinic Dehydratase, Glutathione Peroxidase and Na+,K+-ATPase Activities and Glutathione-Reduced Levels in Rat Hippocampus After Pilocarpine-Induced Seizures

Freitas

2009

Cell Mol Neurobiol

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In the present study, we investigated the effects of lipoic acid (LA) in the brain oxidative stress caused by pilocarpine-induced seizures in adult rats. Wistar rats were treated with 0.9% saline (i.p., control group), lipoic acid (10 mg/kg, i.p., LA group), pilocarpine (400 mg/kg, i.p., pilocarpine group), and the association of LA (10 mg/kg, i.p.) plus pilocarpine (400 mg/kg, i.p.), 30 min before the administration of LA (LA plus pilocarpine group). After the treatments, all groups were observed for 1 h. The enzyme activities [delta-aminolevulinic dehydratase (delta-ALA-D), glutathione peroxidase (GPx), glutathione reductase (GR), and Na+,K+-ATPase] as well as the glutathione-reduced (GSH) and ascorbic acid (AA) concentrations were measured using spectrophotometric methods, and the results were compared to values obtained from saline and pilocarpine-treated animals. Protective effects of LA were also evaluated on the same parameters. In pilocarpine group, no changes were observed in GPx and GR activities and AA content. Moreover, in the same group, decrease in GSH levels as well as a reduction in delta-ALA-D and Na+,K+-ATPase activities after seizures was observed. In turn, in LA plus pilocarpine group, the appearance of seizures was abolished, and the decreases in delta-ALA-D and Na+,K+-ATPase activities produced by seizures as well as increases in GSH levels and GPx activity were reversed, when compared to the pilocarpine seizing group. The results of the present study demonstrated that preadministration of LA abolished seizure episodes induced by pilocarpine in rat, probably by reducing oxidative stress in rat hippocampus caused by seizures.

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Involvement of oxidative stress in seizures induced by diphenyl diselenide in rat pups

Cited by 38 publications

References 33 publications

Effect of oral administration of diphenyl diselenide on antioxidant status, and activity of delta aminolevulinic acid dehydratase and isoforms of lactate dehydrogenase, in streptozotocin-induced diabetic rats

Effect of oral administration of diphenyl diselenide on antioxidant status, and activity of delta aminolevulinic acid dehydratase and isoforms of lactate dehydrogenase, in streptozotocin-induced diabetic rats

Diphenyl diselenide a janus-faced molecule

Lipoic Acid Alters δ-Aminolevulinic Dehydratase, Glutathione Peroxidase and Na+,K+-ATPase Activities and Glutathione-Reduced Levels in Rat Hippocampus After Pilocarpine-Induced Seizures

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