2011
DOI: 10.1111/j.1365-2885.2011.01310.x
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Involvement of P‐glycoprotein and cytochrome P450 3A in the metabolism of florfenicol of rabbits

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Cited by 20 publications
(28 citation statements)
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“…(), the three polyether ionophores were able to induce hepatic cytochrome P450 3A (CYP 3A) in chickens that received the same dosage regimes; this may have resulted in the acceleration of metabolism of FFC. Second, CYP 3A is critical in the metabolism of FFC in rabbits (Liu et al ., ). Although there are differences in animal species, it may also play an important role in chickens.…”
Section: Discussionmentioning
confidence: 97%
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“…(), the three polyether ionophores were able to induce hepatic cytochrome P450 3A (CYP 3A) in chickens that received the same dosage regimes; this may have resulted in the acceleration of metabolism of FFC. Second, CYP 3A is critical in the metabolism of FFC in rabbits (Liu et al ., ). Although there are differences in animal species, it may also play an important role in chickens.…”
Section: Discussionmentioning
confidence: 97%
“…Because CYP 3A and P‐gp are constitutively expressed in the intestine and form an obstacle for drug metabolism (Chan et al ., ; Kunta & Sinko, ), the increased expression of CYP 3A in the intestine induced by the three polyether ionophores may explain why much more FFC was eliminated from the body before it reached the liver. Furthermore, because of the critical effect of hepatic CYP 3A on the metabolism of FFC (Liu et al ., ), much more FFC was metabolized by CYP 3A when it entered the liver. On the other hand, when FFC was given i.v., it directly entered the blood and was metabolized by CYP 3A in the liver.…”
Section: Discussionmentioning
confidence: 98%
“…There is another reason why florfenicol's pharmacokinetic parameters in poultry may vary with prebiotic or probiotic use over a lengthy period of time as chronic therapy may result in florfenicol excretion dysfunction in urine by some adjustment of urine pH or decrease florfenicol excretion in kidney tubules. P‐glycoprotein (P‐gp) is a transporter found in most tissues, particularly in rabbits, that plays a critical role in the FFC disposal (Liu et al, ). For instance, P‐gp may be particular in intestinal tissue for foecal excretion, liver bile secretion and kidney renal excretion.…”
Section: Discussionmentioning
confidence: 99%
“…Production of ROS as a result of biochemical changes can be easily recorded in antibiotic-treated organisms. However, the results of impaired levels of biochemical markers can be different depending on drug concentration, time, or animal species (Farombi 2001;Caipang et al 2009;Kladna et al 2012;Liu et al 2012Liu et al , 2014Elia et al 2014;Ren et al 2014). While the effects of chloramphenicol (Farombi 2001;Monari et al 2008) and other pharmaceuticals (Erdoğan et al 2004;Liu et al 2014) on fish and mammals are widely documented, little information is available for FF (Caipang et al 2009;Liu et al 2012;Ren et al 2014Ren et al , 2016.…”
Section: Discussionmentioning
confidence: 99%
“…Both ethoxyresorufin-O-deethylase (EROD) and GST enzymes can play important roles in the detoxification of FF in aquatic organisms (Ren et al 2016), which emphasizes their roles in FF metabolism. Indeed, inhibition of CYP3A decreased the removal of FF leading to increased bioavailability of the antibiotic in rats (Liu et al 2012). Since the GST enzyme is involved in the detoxification of various electrophilic agents, a higher enzyme activity, as assessed with the substrate CDNB, would indicate a strengthening of the detoxifying ability necessary to offset the pro-oxidant effects induced by antibiotics (Li et al 2013).…”
Section: Discussionmentioning
confidence: 99%